periodontitis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology) (Experimental Factor Ontology, EFO_0000649)
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Genes

164 genes co-occuring with the biological term periodontitis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADAM17 ADAM metallopeptidase domain 17
ADM adrenomedullin
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP3 aquaporin 3 (Gill blood group)
BCL2 B-cell CLL/lymphoma 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
C5 complement component 5
CAMP cathelicidin antimicrobial peptide
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD180 CD180 molecule
CD28 CD28 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSC cathepsin C
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEFA1 defensin, alpha 1
DEFA3 defensin, alpha 3, neutrophil-specific
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DGKA diacylglycerol kinase, alpha 80kDa
DMP1 dentin matrix acidic phosphoprotein 1
EBI3 Epstein-Barr virus induced 3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELANE elastase, neutrophil expressed
ENG endoglin
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FOXP3 forkhead box P3
FPR1 formyl peptide receptor 1
GLT6D1 glycosyltransferase 6 domain containing 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HP haptoglobin
HTN3 histatin 3
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL11 interleukin 11
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL16 interleukin 16
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF4 interferon regulatory factor 4
LTF lactotransferrin
LYZ lysozyme
MBL2 mannose-binding lectin (protein C) 2, soluble
MICA MHC class I polypeptide-related sequence A
MIR130A microRNA 130a
MIR520D microRNA 520d
MIRLET7A1 microRNA let-7a-1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MUC7 mucin 7, secreted
NAMPT nicotinamide phosphoribosyltransferase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NR1I2 nuclear receptor subfamily 1, group I, member 2
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
OSM oncostatin M
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDPN podoplanin
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RETN resistin
RIPK2 receptor-interacting serine-threonine kinase 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPD surfactant protein D
SLAMF7 SLAM family member 7
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMC3 structural maintenance of chromosomes 3
SOCS1 suppressor of cytokine signaling 1
SP1 Sp1 transcription factor
STAT1 signal transducer and activator of transcription 1, 91kDa
TANK TRAF family member-associated NFKB activator
TGFB1 transforming growth factor, beta 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A