perhexiline-7441 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the perhexiline-7441 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATF3 activating transcription factor 3
BBS9 Bardet-Biedl syndrome 9
BHLHE40 basic helix-loop-helix family, member e40
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGA glycoprotein hormones, alpha polypeptide
CHKB choline kinase beta
CNGB3 cyclic nucleotide gated channel beta 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA2 golgin A2
GRTP1 growth hormone regulated TBC protein 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BO histone cluster 1, H2bo
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL4R interleukin 4 receptor
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JAKMIP2 janus kinase and microtubule interacting protein 2
JUN jun proto-oncogene
KIF3C kinesin family member 3C
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LZTFL1 leucine zipper transcription factor-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MZF1 myeloid zinc finger 1
N4BP3 NEDD4 binding protein 3
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NDE1 nudE neurodevelopment protein 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF1 neurofibromin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
ORAI3 ORAI calcium release-activated calcium modulator 3
PACS1 phosphofurin acidic cluster sorting protein 1
PAQR6 progestin and adipoQ receptor family member VI
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRB paired immunoglobin-like type 2 receptor beta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SH2D3A SH2 domain containing 3A
SH3BP2 SH3-domain binding protein 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SMAD3 SMAD family member 3
SMIM14 small integral membrane protein 14
SQLE squalene epoxidase
STK17B serine/threonine kinase 17b
SYNGR1 synaptogyrin 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
TUBG2 tubulin, gamma 2
USP48 ubiquitin specific peptidase 48
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB10 zinc finger and BTB domain containing 10
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARL15 ADP-ribosylation factor-like 15
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BTBD2 BTB (POZ) domain containing 2
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
C1ORF106 chromosome 1 open reading frame 106
C2CD2 C2 calcium-dependent domain containing 2
CCND3 cyclin D3
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHMP6 charged multivesicular body protein 6
CLSPN claspin
CPTP ceramide-1-phosphate transfer protein
CTPS1 CTP synthase 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DTWD1 DTW domain containing 1
ECHDC3 enoyl CoA hydratase domain containing 3
ERCC3 excision repair cross-complementation group 3
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM63A family with sequence similarity 63, member A
FAM86C1 family with sequence similarity 86, member C1
FASTKD1 FAST kinase domains 1
FCHO1 FCH domain only 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAR1 GAR1 ribonucleoprotein
GHR growth hormone receptor
GJA1 gap junction protein, alpha 1, 43kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLGA8B golgin A8 family, member B
GPRASP1 G protein-coupled receptor associated sorting protein 1
H2AFY2 H2A histone family, member Y2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
IMPACT impact RWD domain protein
INTS9 integrator complex subunit 9
IP6K1 inositol hexakisphosphate kinase 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KATNBL1 katanin p80 subunit B-like 1
KIF5C kinesin family member 5C
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB2 lamin B2
LOC100287590 uncharacterized LOC100287590
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MYO9A myosin IXA
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NTHL1 nth endonuclease III-like 1 (E. coli)
OGFRL1 opioid growth factor receptor-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PGP phosphoglycolate phosphatase
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLD3 phospholipase D family, member 3
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRR15L proline rich 15-like
PTCD1 pentatricopeptide repeat domain 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF123 ring finger protein 123
RPP40 ribonuclease P/MRP 40kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRP1 ribosomal RNA processing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SHPK sedoheptulokinase
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC46A3 solute carrier family 46, member 3
SNIP1 Smad nuclear interacting protein 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TET3 tet methylcytosine dioxygenase 3
TEX30 testis expressed 30
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TIPIN TIMELESS interacting protein
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VAV1 vav 1 guanine nucleotide exchange factor
WDR43 WD repeat domain 43
WDR47 WD repeat domain 47
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZC3H3 zinc finger CCCH-type containing 3
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZW10 zw10 kinetochore protein