perhexiline-2410 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the perhexiline-2410 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCL3 B-cell CLL/lymphoma 3
BTG2 BTG family, member 2
CCDC186 coiled-coil domain containing 186
CCNG2 cyclin G2
CD83 CD83 molecule
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COQ6 coenzyme Q6 monooxygenase
CSNK1E casein kinase 1, epsilon
CTNS cystinosin, lysosomal cystine transporter
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DGCR8 DGCR8 microprocessor complex subunit
DHCR7 7-dehydrocholesterol reductase
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO1 forkhead box O1
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GOLGA2 golgin A2
GPNMB glycoprotein (transmembrane) nmb
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HHLA3 HERV-H LTR-associating 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2AM histone cluster 1, H2am
HIST1H2BH histone cluster 1, H2bh
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA1 homeobox A1
ICA1 islet cell autoantigen 1, 69kDa
ICK intestinal cell (MAK-like) kinase
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL22 interleukin 22
KDM7A lysine (K)-specific demethylase 7A
KIAA1109 KIAA1109
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMA4 laminin, alpha 4
LGALS3 lectin, galactoside-binding, soluble, 3
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY96 lymphocyte antigen 96
MCOLN1 mucolipin 1
MKL2 MKL/myocardin-like 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MVK mevalonate kinase
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PGAP3 post-GPI attachment to proteins 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLSCR1 phospholipid scramblase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS1 regulator of G-protein signaling 1
RUNX1 runt-related transcription factor 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOS2 son of sevenless homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SS18 synovial sarcoma translocation, chromosome 18
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D17 TBC1 domain family, member 17
TMBIM1 transmembrane BAX inhibitor motif containing 1
TRIM3 tripartite motif containing 3
TSC22D4 TSC22 domain family, member 4
VCX2 variable charge, X-linked 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB17 zinc finger and BTB domain containing 17
ZNF500 zinc finger protein 500
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ACP2 acid phosphatase 2, lysosomal
ADGRA3 adhesion G protein-coupled receptor A3
ADM adrenomedullin
AEN apoptosis enhancing nuclease
ALS2CL ALS2 C-terminal like
ANKFY1 ankyrin repeat and FYVE domain containing 1
ASPN asporin
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C12ORF43 chromosome 12 open reading frame 43
C3 complement component 3
CBR1 carbonyl reductase 1
CCDC85C coiled-coil domain containing 85C
CCDC86 coiled-coil domain containing 86
CD320 CD320 molecule
CDR2L cerebellar degeneration-related protein 2-like
CFD complement factor D (adipsin)
CHMP6 charged multivesicular body protein 6
CHST10 carbohydrate sulfotransferase 10
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae)
COLEC10 collectin sub-family member 10 (C-type lectin)
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBR1 debranching RNA lariats 1
DDN dendrin
DEPDC5 DEP domain containing 5
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS3 dehydrogenase/reductase (SDR family) member 3
E4F1 E4F transcription factor 1
FAM46A family with sequence similarity 46, member A
FAM50B family with sequence similarity 50, member B
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCHO1 FCH domain only 1
FGL1 fibrinogen-like 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIP2 glutamate receptor interacting protein 2
HAMP hepcidin antimicrobial peptide
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPA4L heat shock 70kDa protein 4-like
HYAL2 hyaluronoglucosaminidase 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IPO8 importin 8
KLHDC4 kelch domain containing 4
LRP5 low density lipoprotein receptor-related protein 5
LTBP2 latent transforming growth factor beta binding protein 2
LYPLA2P1 lysophospholipase II pseudogene 1
MED22 mediator complex subunit 22
METRN meteorin, glial cell differentiation regulator
METTL16 methyltransferase like 16
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL16 mitochondrial ribosomal protein L16
MTA2 metastasis associated 1 family, member 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NAT10 N-acetyltransferase 10 (GCN5-related)
NCS1 neuronal calcium sensor 1
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NTHL1 nth endonuclease III-like 1 (E. coli)
NTSR1 neurotensin receptor 1 (high affinity)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDZD7 PDZ domain containing 7
PLS1 plastin 1
PMPCA peptidase (mitochondrial processing) alpha
PODXL2 podocalyxin-like 2
POM121 POM121 transmembrane nucleoporin
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PRDX4 peroxiredoxin 4
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRTN3 proteinase 3
PYCRL pyrroline-5-carboxylate reductase-like
RBM42 RNA binding motif protein 42
RCL1 RNA terminal phosphate cyclase-like 1
RFTN1 raftlin, lipid raft linker 1
RNF122 ring finger protein 122
RPAP2 RNA polymerase II associated protein 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAI suppressor of cancer cell invasion
SCRIB scribbled planar cell polarity protein
SDF2L1 stromal cell-derived factor 2-like 1
SH2D4A SH2 domain containing 4A
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC39A4 solute carrier family 39 (zinc transporter), member 4
TFB2M transcription factor B2, mitochondrial
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast)
TMEM246 transmembrane protein 246
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTPAL tocopherol (alpha) transfer protein-like
UNC13B unc-13 homolog B (C. elegans)
UPK3A uroplakin 3A
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
VSIG4 V-set and immunoglobulin domain containing 4
YY2 YY2 transcription factor
ZBED1 zinc finger, BED-type containing 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816