pergolide-7271 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pergolide-7271 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADCY6 adenylate cyclase 6
AFF1 AF4/FMR2 family, member 1
AKTIP AKT interacting protein
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ARHGAP26 Rho GTPase activating protein 26
BBS9 Bardet-Biedl syndrome 9
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C10ORF88 chromosome 10 open reading frame 88
C1S complement component 1, s subcomponent
C9ORF40 chromosome 9 open reading frame 40
CA11 carbonic anhydrase XI
CA9 carbonic anhydrase IX
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CDC25A cell division cycle 25A
CEP68 centrosomal protein 68kDa
CSPP1 centrosome and spindle pole associated protein 1
CXCL3 chemokine (C-X-C motif) ligand 3
DNAL4 dynein, axonemal, light chain 4
DPY19L2P2 DPY19L2 pseudogene 2
DXO decapping exoribonuclease
EGFR epidermal growth factor receptor
FAM105A family with sequence similarity 105, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GK glycerol kinase
GM2A GM2 ganglioside activator
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPC1 glypican 1
HN1L hematological and neurological expressed 1-like
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ITM2B integral membrane protein 2B
JAK2 Janus kinase 2
JRK Jrk homolog (mouse)
KIDINS220 kinase D-interacting substrate, 220kDa
KIF5C kinesin family member 5C
KRT32 keratin 32, type I
LMAN1 lectin, mannose-binding, 1
LNPEP leucyl/cystinyl aminopeptidase
LOC730101 uncharacterized LOC730101
LRRC41 leucine rich repeat containing 41
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCL1 myeloid cell leukemia 1
MED28 mediator complex subunit 28
MED7 mediator complex subunit 7
NCKAP1 NCK-associated protein 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PARD3 par-3 family cell polarity regulator
PDGFRL platelet-derived growth factor receptor-like
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PEX7 peroxisomal biogenesis factor 7
PGPEP1 pyroglutamyl-peptidase I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PHTF2 putative homeodomain transcription factor 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX1 PBX/knotted 1 homeobox 1
PRMT2 protein arginine methyltransferase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBBP9 retinoblastoma binding protein 9
RDX radixin
RRP1B ribosomal RNA processing 1B
RUNX1-IT1 RUNX1 intronic transcript 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETDB1 SET domain, bifurcated 1
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFTPB surfactant protein B
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRD5A3 steroid 5 alpha-reductase 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TLE4 transducin-like enhancer of split 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOR1AIP1 torsin A interacting protein 1
TPMT thiopurine S-methyltransferase
TRIM23 tripartite motif containing 23
TRIO trio Rho guanine nucleotide exchange factor
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTLL7 tubulin tyrosine ligase-like family member 7
TXLNG taxilin gamma
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF224 zinc finger protein 224

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
AHDC1 AT hook, DNA binding motif, containing 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATAD3A ATPase family, AAA domain containing 3A
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAK1 BCL2-antagonist/killer 1
C11ORF80 chromosome 11 open reading frame 80
C16ORF62 chromosome 16 open reading frame 62
C8ORF60 chromosome 8 open reading frame 60
C9ORF91 chromosome 9 open reading frame 91
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCNA1 cyclin A1
CCNE1 cyclin E1
CCRL2 chemokine (C-C motif) receptor-like 2
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNGB3 cyclic nucleotide gated channel beta 3
CTAGE9 CTAGE family, member 9
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DET1 de-etiolated homolog 1 (Arabidopsis)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLL3 delta-like 3 (Drosophila)
ERF Ets2 repressor factor
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FBXO46 F-box protein 46
FGF2 fibroblast growth factor 2 (basic)
FUZ fuzzy planar cell polarity protein
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GMIP GEM interacting protein
GPATCH3 G patch domain containing 3
GRAMD4 GRAM domain containing 4
HCFC2 host cell factor C2
HLX H2.0-like homeobox
HOXA4 homeobox A4
HSPA2 heat shock 70kDa protein 2
INF2 inverted formin, FH2 and WH2 domain containing
KDM4D lysine (K)-specific demethylase 4D
KLF2 Kruppel-like factor 2
KRT15 keratin 15, type I
LPAR4 lysophosphatidic acid receptor 4
LPAR6 lysophosphatidic acid receptor 6
LYPLA2P1 lysophospholipase II pseudogene 1
MACROD1 MACRO domain containing 1
MED9 mediator complex subunit 9
MFSD11 major facilitator superfamily domain containing 11
MFSD12 major facilitator superfamily domain containing 12
MXD3 MAX dimerization protein 3
MYLK myosin light chain kinase
NAG18 NAG18 mRNA
NME3 NME/NM23 nucleoside diphosphate kinase 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUBP2 nucleotide binding protein 2
OSBP2 oxysterol binding protein 2
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP16 poly (ADP-ribose) polymerase family, member 16
PDE8B phosphodiesterase 8B
PIAS3 protein inhibitor of activated STAT, 3
PRR3 proline rich 3
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB17 RAB17, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RFTN1 raftlin, lipid raft linker 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SAMD9 sterile alpha motif domain containing 9
SH3BGR SH3 domain binding glutamate-rich protein
SIX1 SIX homeobox 1
SLC12A8 solute carrier family 12, member 8
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SSNA1 Sjogren syndrome nuclear autoantigen 1
STIM1 stromal interaction molecule 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAOK1 TAO kinase 1
TESPA1 thymocyte expressed, positive selection associated 1
THOC6 THO complex 6
TMEM132A transmembrane protein 132A
TMEM209 transmembrane protein 209
TNRC6B trinucleotide repeat containing 6B
TNS2 tensin 2
TSKU tsukushi, small leucine rich proteoglycan
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
VWA1 von Willebrand factor A domain containing 1
WFS1 Wolfram syndrome 1 (wolframin)
XPC xeroderma pigmentosum, complementation group C
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZNF222 zinc finger protein 222
ZNF282 zinc finger protein 282
ZNF350 zinc finger protein 350
ZNF415 zinc finger protein 415