pentoxifylline-7319 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pentoxifylline-7319 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACVR1B activin A receptor, type IB
ADRBK1 adrenergic, beta, receptor kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALPK1 alpha-kinase 1
AMBRA1 autophagy/beclin-1 regulator 1
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
ARTN artemin
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BICD1 bicaudal D homolog 1 (Drosophila)
C16ORF59 chromosome 16 open reading frame 59
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CADM3 cell adhesion molecule 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL21 chemokine (C-C motif) ligand 21
CD40 CD40 molecule, TNF receptor superfamily member 5
CD6 CD6 molecule
CDK3 cyclin-dependent kinase 3
CIB2 calcium and integrin binding family member 2
CSPP1 centrosome and spindle pole associated protein 1
CTNND2 catenin (cadherin-associated protein), delta 2
CXCR2 chemokine (C-X-C motif) receptor 2
DENND4A DENN/MADD domain containing 4A
DUSP10 dual specificity phosphatase 10
DUSP8 dual specificity phosphatase 8
ELOVL5 ELOVL fatty acid elongase 5
EPPK1 epiplakin 1
ERP44 endoplasmic reticulum protein 44
FAM188A family with sequence similarity 188, member A
FAM63B family with sequence similarity 63, member B
FLJ21369 uncharacterized protein FLJ21369
FOXG1 forkhead box G1
GLRX3 glutaredoxin 3
GPR107 G protein-coupled receptor 107
H2AFJ H2A histone family, member J
HHEX hematopoietically expressed homeobox
HNF1B HNF1 homeobox B
HOXA2 homeobox A2
HOXA4 homeobox A4
IFFO1 intermediate filament family orphan 1
IL24 interleukin 24
IZUMO4 IZUMO family member 4
JMJD6 jumonji domain containing 6
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KLHL20 kelch-like family member 20
LRRC61 leucine rich repeat containing 61
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK11 mitogen-activated protein kinase 11
MARS methionyl-tRNA synthetase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MYRF myelin regulatory factor
NDE1 nudE neurodevelopment protein 1
NEK11 NIMA-related kinase 11
NF2 neurofibromin 2 (merlin)
NINJ1 ninjurin 1
NOD1 nucleotide-binding oligomerization domain containing 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OLFML3 olfactomedin-like 3
OSBP2 oxysterol binding protein 2
PDCD6 programmed cell death 6
PDE4D phosphodiesterase 4D, cAMP-specific
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDLIM3 PDZ and LIM domain 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAD51B RAD51 paralog B
RBBP9 retinoblastoma binding protein 9
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RGS14 regulator of G-protein signaling 14
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SARM1 sterile alpha and TIR motif containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC12A8 solute carrier family 12, member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC46A3 solute carrier family 46, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SRSF6 serine/arginine-rich splicing factor 6
SYNJ2 synaptojanin 2
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAPBP TAP binding protein (tapasin)
TBC1D22A TBC1 domain family, member 22A
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE3 transducin-like enhancer of split 3
TMEM53 transmembrane protein 53
TMEM63A transmembrane protein 63A
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPM2 tropomyosin 2 (beta)
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA4B tubulin, alpha 4b
VIPR2 vasoactive intestinal peptide receptor 2
VWA5A von Willebrand factor A domain containing 5A
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AEN apoptosis enhancing nuclease
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA2P3 annexin A2 pseudogene 3
APLP1 amyloid beta (A4) precursor-like protein 1
APOC1 apolipoprotein C-I
ARHGAP24 Rho GTPase activating protein 24
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ATP10D ATPase, class V, type 10D
ATXN2 ataxin 2
BAK1 BCL2-antagonist/killer 1
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
C11ORF71 chromosome 11 open reading frame 71
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CCDC68 coiled-coil domain containing 68
CCP110 centriolar coiled coil protein 110kDa
CCRL2 chemokine (C-C motif) receptor-like 2
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKL3 cyclin-dependent kinase-like 3
CDKN2AIP CDKN2A interacting protein
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNN2 calponin 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCP1A decapping mRNA 1A
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DLK1 delta-like 1 homolog (Drosophila)
EAF2 ELL associated factor 2
EFNA3 ephrin-A3
EGF epidermal growth factor
ERCC2 excision repair cross-complementation group 2
EXTL3 exostosin-like glycosyltransferase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FBXL15 F-box and leucine-rich repeat protein 15
FIG4 FIG4 phosphoinositide 5-phosphatase
FSD1 fibronectin type III and SPRY domain containing 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJC1 gap junction protein, gamma 1, 45kDa
GPATCH2L G patch domain containing 2-like
HIST1H4D histone cluster 1, H4d
HOXC8 homeobox C8
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD20 potassium channel tetramerization domain containing 20
KLHL3 kelch-like family member 3
MANBA mannosidase, beta A, lysosomal
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MPI mannose phosphate isomerase
MRPL44 mitochondrial ribosomal protein L44
MXRA8 matrix-remodelling associated 8
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFS1 NFS1 cysteine desulfurase
OGDHL oxoglutarate dehydrogenase-like
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAIP2B poly(A) binding protein interacting protein 2B
PDGFRL platelet-derived growth factor receptor-like
PLA2G15 phospholipase A2, group XV
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRICKLE3 prickle homolog 3 (Drosophila)
PSKH1 protein serine kinase H1
RAD51AP1 RAD51 associated protein 1
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
SALL2 spalt-like transcription factor 2
SEPP1 selenoprotein P, plasma, 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STAR steroidogenic acute regulatory protein
STK16 serine/threonine kinase 16
TMEM183A transmembrane protein 183A
TMEM19 transmembrane protein 19
TMEM212 transmembrane protein 212
TMEM62 transmembrane protein 62
TMEM8B transmembrane protein 8B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNNI3 troponin I type 3 (cardiac)
TRABD TraB domain containing
TSKU tsukushi, small leucine rich proteoglycan
USP6NL USP6 N-terminal like
VEZT vezatin, adherens junctions transmembrane protein
WDR91 WD repeat domain 91
WFS1 Wolfram syndrome 1 (wolframin)
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZC3H12A zinc finger CCCH-type containing 12A
ZNF273 zinc finger protein 273
ZNF510 zinc finger protein 510
ZNF668 zinc finger protein 668