pentolonium-7375 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the pentolonium-7375 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ACRV1 acrosomal vesicle protein 1
ADCK2 aarF domain containing kinase 2
ALAD aminolevulinate dehydratase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMACR alpha-methylacyl-CoA racemase
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BGLAP bone gamma-carboxyglutamate (gla) protein
BTC betacellulin
C6ORF10 chromosome 6 open reading frame 10
CABIN1 calcineurin binding protein 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CDHR2 cadherin-related family member 2
CGREF1 cell growth regulator with EF-hand domain 1
CLDN11 claudin 11
CRY2 cryptochrome circadian clock 2
CSF1 colony stimulating factor 1 (macrophage)
CTNND2 catenin (cadherin-associated protein), delta 2
CUL7 cullin 7
DOCK5 dedicator of cytokinesis 5
DOCK6 dedicator of cytokinesis 6
DOHH deoxyhypusine hydroxylase/monooxygenase
DOK5 docking protein 5
DPF3 D4, zinc and double PHD fingers, family 3
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
EDNRB endothelin receptor type B
EFNA3 ephrin-A3
EFS embryonal Fyn-associated substrate
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMP1 epithelial membrane protein 1
FAM120C family with sequence similarity 120C
GLRX3 glutaredoxin 3
GPR135 G protein-coupled receptor 135
GREM2 gremlin 2, DAN family BMP antagonist
GRIK5 glutamate receptor, ionotropic, kainate 5
HNF1B HNF1 homeobox B
HSF2BP heat shock transcription factor 2 binding protein
IFT27 intraflagellar transport 27
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL17RA interleukin 17 receptor A
ITGB8 integrin, beta 8
JMJD6 jumonji domain containing 6
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LMF2 lipase maturation factor 2
LPAR4 lysophosphatidic acid receptor 4
LRRK1 leucine-rich repeat kinase 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED16 mediator complex subunit 16
METTL7A methyltransferase like 7A
MIIP migration and invasion inhibitory protein
MKL1 megakaryoblastic leukemia (translocation) 1
NAAA N-acylethanolamine acid amidase
NAIP NLR family, apoptosis inhibitory protein
NAT6 N-acetyltransferase 6 (GCN5-related)
NR2F6 nuclear receptor subfamily 2, group F, member 6
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMP2 peripheral myelin protein 2
PRKCE protein kinase C, epsilon
PRKG2 protein kinase, cGMP-dependent, type II
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
R3HDM1 R3H domain containing 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL5 ribosomal protein L5
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAPCD1 suppressor APC domain containing 1
SARM1 sterile alpha and TIR motif containing 1
SETD1A SET domain containing 1A
SHROOM2 shroom family member 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SND1-IT1 SND1 intronic transcript 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFB1 transforming growth factor, beta 1
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TJAP1 tight junction associated protein 1 (peripheral)
TMEM63A transmembrane protein 63A
TRIL TLR4 interactor with leucine-rich repeats
TRIO trio Rho guanine nucleotide exchange factor
TSFM Ts translation elongation factor, mitochondrial
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF606 zinc finger protein 606
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFAP1 actin filament associated protein 1
ALS2CL ALS2 C-terminal like
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC6 armadillo repeat containing 6
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
BAK1 BCL2-antagonist/killer 1
BCL9 B-cell CLL/lymphoma 9
C16ORF59 chromosome 16 open reading frame 59
CBX8 chromobox homolog 8
CDH7 cadherin 7, type 2
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPO centromere protein O
CLEC10A C-type lectin domain family 10, member A
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTSK cathepsin K
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYTH2 cytohesin 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DHRS11 dehydrogenase/reductase (SDR family) member 11
DSN1 DSN1, MIS12 kinetochore complex component
DTWD1 DTW domain containing 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ELP3 elongator acetyltransferase complex subunit 3
ELP6 elongator acetyltransferase complex subunit 6
EMD emerin
EPN3 epsin 3
ETAA1 Ewing tumor-associated antigen 1
EVPL envoplakin
FAM53B family with sequence similarity 53, member B
FCHO1 FCH domain only 1
FOXA1 forkhead box A1
FUBP3 far upstream element (FUSE) binding protein 3
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GDAP1 ganglioside induced differentiation associated protein 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP2 GTP binding protein 2
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIST1H2AM histone cluster 1, H2am
IKZF5 IKAROS family zinc finger 5 (Pegasus)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHX6 LIM homeobox 6
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPAR3 lysophosphatidic acid receptor 3
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MINPP1 multiple inositol-polyphosphate phosphatase 1
MRPL46 mitochondrial ribosomal protein L46
MUM1 melanoma associated antigen (mutated) 1
NMB neuromedin B
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
NUPR1 nuclear protein, transcriptional regulator, 1
PAQR4 progestin and adipoQ receptor family member IV
PECR peroxisomal trans-2-enoyl-CoA reductase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PID1 phosphotyrosine interaction domain containing 1
PLCD1 phospholipase C, delta 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF31 ring finger protein 31
SCARA3 scavenger receptor class A, member 3
SETD6 SET domain containing 6
SH3GL2 SH3-domain GRB2-like 2
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNTA1 syntrophin, alpha 1
SNX10 sorting nexin 10
SP140L SP140 nuclear body protein-like
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TMEM159 transmembrane protein 159
TMEM2 transmembrane protein 2
TMEM209 transmembrane protein 209
TMEM38B transmembrane protein 38B
TMEM80 transmembrane protein 80
TMEM8B transmembrane protein 8B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRIM9 tripartite motif containing 9
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TWF2 twinfilin actin binding protein 2
UBTD1 ubiquitin domain containing 1
UNC119 unc-119 homolog (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR18 WD repeat domain 18
ZNF34 zinc finger protein 34
ZNF552 zinc finger protein 552
ZNF671 zinc finger protein 671
ZNF816 zinc finger protein 816