pentolonium-2305 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the pentolonium-2305 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AHNAK2 AHNAK nucleoprotein 2
ARL4C ADP-ribosylation factor-like 4C
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASPH aspartate beta-hydroxylase
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BHLHE41 basic helix-loop-helix family, member e41
CALB2 calbindin 2
CBX2 chromobox homolog 2
CCDC64 coiled-coil domain containing 64
CD1A CD1a molecule
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLPS colipase, pancreatic
CLTC clathrin, heavy chain (Hc)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DGAT1 diacylglycerol O-acyltransferase 1
DNALI1 dynein, axonemal, light intermediate chain 1
DSC2 desmocollin 2
FADS2 fatty acid desaturase 2
FAM135A family with sequence similarity 135, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF6 fibroblast growth factor 6
FGFR1 fibroblast growth factor receptor 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GFAP glial fibrillary acidic protein
GMPR guanosine monophosphate reductase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRM8 glutamate receptor, metabotropic 8
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HHLA1 HERV-H LTR-associating 1
HR hair growth associated
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL11 interleukin 11
IL25 interleukin 25
KIAA0894 KIAA0894 protein
KIF1C kinesin family member 1C
KLK2 kallikrein-related peptidase 2
KRT8 keratin 8, type II
LCN1 lipocalin 1
LEFTY2 left-right determination factor 2
LIMCH1 LIM and calponin homology domains 1
LINC00341 long intergenic non-protein coding RNA 341
LOC157562 uncharacterized LOC157562
LRRTM2 leucine rich repeat transmembrane neuronal 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MDM4 MDM4, p53 regulator
MED25 mediator complex subunit 25
MFAP5 microfibrillar associated protein 5
MST1L macrophage stimulating 1-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NEUROD4 neuronal differentiation 4
NPTX2 neuronal pentraxin II
OTOR otoraplin
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PDZRN4 PDZ domain containing ring finger 4
PIGR polymeric immunoglobulin receptor
PLCD1 phospholipase C, delta 1
PML promyelocytic leukemia
PTCRA pre T-cell antigen receptor alpha
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBFA ribosome binding factor A (putative)
RELN reelin
RGS14 regulator of G-protein signaling 14
RPS3A ribosomal protein S3A
SECTM1 secreted and transmembrane 1
SERHL2 serine hydrolase-like 2
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SNX1 sorting nexin 1
SOX10 SRY (sex determining region Y)-box 10
SPAG6 sperm associated antigen 6
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPRR1A small proline-rich protein 1A
SPTBN4 spectrin, beta, non-erythrocytic 4
STK17A serine/threonine kinase 17a
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBXA2R thromboxane A2 receptor
TCHH trichohyalin
TFEB transcription factor EB
TLN1 talin 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TROVE2 TROVE domain family, member 2
UPK3B uroplakin 3B
WNT16 wingless-type MMTV integration site family, member 16
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB43 zinc finger and BTB domain containing 43
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFAP1 actin filament associated protein 1
AHDC1 AT hook, DNA binding motif, containing 1
ALS2CL ALS2 C-terminal like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BCL9 B-cell CLL/lymphoma 9
BCOR BCL6 corepressor
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
C21ORF91 chromosome 21 open reading frame 91
C2ORF49 chromosome 2 open reading frame 49
CA5BP1 carbonic anhydrase VB pseudogene 1
CDKN2AIP CDKN2A interacting protein
CHML choroideremia-like (Rab escort protein 2)
CINP cyclin-dependent kinase 2 interacting protein
CLSPN claspin
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CPTP ceramide-1-phosphate transfer protein
CUL9 cullin 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DUSP2 dual specificity phosphatase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR21 G protein-coupled receptor 21
GPR87 G protein-coupled receptor 87
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC11 histone deacetylase 11
HIST1H4D histone cluster 1, H4d
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IQSEC2 IQ motif and Sec7 domain 2
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM5C lysine (K)-specific demethylase 5C
KIAA0125 KIAA0125
KLC2 kinesin light chain 2
KLHL21 kelch-like family member 21
MAGEB2 melanoma antigen family B2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCC mutated in colorectal cancers
MNX1 motor neuron and pancreas homeobox 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MUM1 melanoma associated antigen (mutated) 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OSGIN1 oxidative stress induced growth inhibitor 1
PAIP2B poly(A) binding protein interacting protein 2B
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA3 plexin A3
POLL polymerase (DNA directed), lambda
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PRF1 perforin 1 (pore forming protein)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PROS1 protein S (alpha)
PTBP2 polypyrimidine tract binding protein 2
PTPRS protein tyrosine phosphatase, receptor type, S
PTPRU protein tyrosine phosphatase, receptor type, U
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMIM14 small integral membrane protein 14
STAB2 stabilin 2
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM53 transmembrane protein 53
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTBK2 tau tubulin kinase 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP20 ubiquitin specific peptidase 20
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZMYM1 zinc finger, MYM-type 1
ZNF141 zinc finger protein 141
ZNF254 zinc finger protein 254
ZNF354A zinc finger protein 354A
ZNF442 zinc finger protein 442
ZNF468 zinc finger protein 468
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862
ZXDC ZXD family zinc finger C