pentamidine-4396 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pentamidine-4396 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADORA3 adenosine A3 receptor
AIM2 absent in melanoma 2
AJAP1 adherens junctions associated protein 1
ARHGAP26 Rho GTPase activating protein 26
ASIC1 acid sensing (proton gated) ion channel 1
ASIC2 acid sensing (proton gated) ion channel 2
C1QB complement component 1, q subcomponent, B chain
C1QTNF1 C1q and tumor necrosis factor related protein 1
C8A complement component 8, alpha polypeptide
CD200 CD200 molecule
CD8A CD8a molecule
CFAP69 cilia and flagella associated protein 69
CLSTN3 calsyntenin 3
CNTD2 cyclin N-terminal domain containing 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR2 corticotropin releasing hormone receptor 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CYTH4 cytohesin 4
DMPK dystrophia myotonica-protein kinase
DUSP6 dual specificity phosphatase 6
ECE1 endothelin converting enzyme 1
EPN1 epsin 1
FOXF1 forkhead box F1
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GHRH growth hormone releasing hormone
GJA4 gap junction protein, alpha 4, 37kDa
GOLGA6A golgin A6 family, member A
GPR4 G protein-coupled receptor 4
GRAP GRB2-related adaptor protein
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
ICOS inducible T-cell co-stimulator
IDI2-AS1 IDI2 antisense RNA 1
IL11RA interleukin 11 receptor, alpha
IRF8 interferon regulatory factor 8
ITM2C integral membrane protein 2C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIF25-AS1 KIF25 antisense RNA 1
KLF13 Kruppel-like factor 13
KLF6 Kruppel-like factor 6
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK1 LIM domain kinase 1
MAOA monoamine oxidase A
MARS methionyl-tRNA synthetase
MDFI MyoD family inhibitor
MED25 mediator complex subunit 25
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MORN1 MORN repeat containing 1
MRC2 mannose receptor, C type 2
MYLK myosin light chain kinase
OLFM1 olfactomedin 1
ONECUT2 one cut homeobox 2
P3H2 prolyl 3-hydroxylase 2
PAX8 paired box 8
PCDH1 protocadherin 1
PCNX pecanex homolog (Drosophila)
PGAP3 post-GPI attachment to proteins 3
PML promyelocytic leukemia
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTX3 pentraxin 3, long
PWAR5 Prader Willi/Angelman region RNA 5
RAB36 RAB36, member RAS oncogene family
RARA retinoic acid receptor, alpha
RGS4 regulator of G-protein signaling 4
RHBG Rh family, B glycoprotein (gene/pseudogene)
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD6 SMAD family member 6
SPRY4 sprouty homolog 4 (Drosophila)
STAC SH3 and cysteine rich domain
STAT2 signal transducer and activator of transcription 2, 113kDa
TAOK2 TAO kinase 2
TBKBP1 TBK1 binding protein 1
TBX10 T-box 10
TLR2 toll-like receptor 2
TMPRSS4 transmembrane protease, serine 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
ZEB1 zinc finger E-box binding homeobox 1
ZNF277 zinc finger protein 277
ZNF358 zinc finger protein 358
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AFAP1 actin filament associated protein 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
ASAP1-IT1 ASAP1 intronic transcript 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAX BCL2-associated X protein
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C11ORF30 chromosome 11 open reading frame 30
C11ORF63 chromosome 11 open reading frame 63
C1ORF21 chromosome 1 open reading frame 21
C2CD2 C2 calcium-dependent domain containing 2
C8ORF60 chromosome 8 open reading frame 60
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CENPQ centromere protein Q
CEP97 centrosomal protein 97kDa
CFAP45 cilia and flagella associated protein 45
CGA glycoprotein hormones, alpha polypeptide
CHKB choline kinase beta
CLCN6 chloride channel, voltage-sensitive 6
CRYGC crystallin, gamma C
CSF1R colony stimulating factor 1 receptor
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLK2 delta-like 2 homolog (Drosophila)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYSF dysferlin
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
ETV6 ets variant 6
FAAH fatty acid amide hydrolase
FBXL8 F-box and leucine-rich repeat protein 8
FRS2 fibroblast growth factor receptor substrate 2
GBP2 guanylate binding protein 2, interferon-inducible
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR143 G protein-coupled receptor 143
GRAMD1C GRAM domain containing 1C
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HHAT hedgehog acyltransferase
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HIST1H4D histone cluster 1, H4d
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL22 interleukin 22
IQSEC2 IQ motif and Sec7 domain 2
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LMNB1 lamin B1
LRRC20 leucine rich repeat containing 20
LZTR1 leucine-zipper-like transcription regulator 1
MAP1S microtubule-associated protein 1S
MAP9 microtubule-associated protein 9
MED9 mediator complex subunit 9
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MX2 MX dynamin-like GTPase 2
NLRX1 NLR family member X1
ODF2 outer dense fiber of sperm tails 2
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB3 protocadherin beta 3
PGPEP1 pyroglutamyl-peptidase I
PRAMEF11 PRAME family member 11
QSER1 glutamine and serine rich 1
RAB3D RAB3D, member RAS oncogene family
RNF122 ring finger protein 122
SCD5 stearoyl-CoA desaturase 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIX1 SIX homeobox 1
SLC12A9 solute carrier family 12, member 9
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SP1 Sp1 transcription factor
SSPN sarcospan
STK16 serine/threonine kinase 16
STRA6 stimulated by retinoic acid 6
TARP TCR gamma alternate reading frame protein
TM6SF1 transmembrane 6 superfamily member 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TPK1 thiamin pyrophosphokinase 1
TPSG1 tryptase gamma 1
TRIM5 tripartite motif containing 5
TSC22D4 TSC22 domain family, member 4
VEZT vezatin, adherens junctions transmembrane protein
VIM vimentin
ZFHX2 zinc finger homeobox 2
ZIC3 Zic family member 3
ZNF10 zinc finger protein 10
ZNF37BP zinc finger protein 37B, pseudogene
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76