penbutolol-7476 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the penbutolol-7476 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ADAP2 ArfGAP with dual PH domains 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANKRD26 ankyrin repeat domain 26
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B9D2 B9 protein domain 2
BTG2 BTG family, member 2
C5AR2 complement component 5a receptor 2
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC64 coiled-coil domain containing 64
CDC14A cell division cycle 14A
CLDN9 claudin 9
CLTA clathrin, light chain A
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DMPK dystrophia myotonica-protein kinase
DNPEP aspartyl aminopeptidase
DUSP4 dual specificity phosphatase 4
EVA1B eva-1 homolog B (C. elegans)
FAAH fatty acid amide hydrolase
FAM155A family with sequence similarity 155, member A
FAM65A family with sequence similarity 65, member A
FSTL4 follistatin-like 4
GAS7 growth arrest-specific 7
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR153 G protein-coupled receptor 153
HEMK1 HemK methyltransferase family member 1
HHAT hedgehog acyltransferase
HIST1H2BN histone cluster 1, H2bn
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL11 interleukin 11
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAK2 Janus kinase 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM2A lysine (K)-specific demethylase 2A
KIAA0355 KIAA0355
KLHL22 kelch-like family member 22
LMO2 LIM domain only 2 (rhombotin-like 1)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1A microtubule-associated protein 1A
MAPK14 mitogen-activated protein kinase 14
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTCP1 mature T-cell proliferation 1
MZF1 myeloid zinc finger 1
NIPAL2 NIPA-like domain containing 2
OASL 2'-5'-oligoadenylate synthetase-like
PARD6B par-6 family cell polarity regulator beta
PIDD1 p53-induced death domain protein 1
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLXNB1 plexin B1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40C RAB40C, member RAS oncogene family
RECQL5 RecQ protein-like 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF126P1 ring finger protein 126 pseudogene 1
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SHARPIN SHANK-associated RH domain interactor
SKAP1 src kinase associated phosphoprotein 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC46A3 solute carrier family 46, member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
STK17B serine/threonine kinase 17b
TBC1D2B TBC1 domain family, member 2B
TFIP11 tuftelin interacting protein 11
THBD thrombomodulin
TOP3B topoisomerase (DNA) III beta
TRIL TLR4 interactor with leucine-rich repeats
VEGFB vascular endothelial growth factor B
VN1R1 vomeronasal 1 receptor 1
YY1 YY1 transcription factor
ZNF134 zinc finger protein 134
ZNF442 zinc finger protein 442
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVR2A activin A receptor, type IIA
ALS2CL ALS2 C-terminal like
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
BAG4 BCL2-associated athanogene 4
C4ORF29 chromosome 4 open reading frame 29
CAPN15 calpain 15
CARD8 caspase recruitment domain family, member 8
CCDC85C coiled-coil domain containing 85C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK3 cyclin-dependent kinase 3
CFD complement factor D (adipsin)
CHKB choline kinase beta
CNGB3 cyclic nucleotide gated channel beta 3
COL4A5 collagen, type IV, alpha 5
DCAF17 DDB1 and CUL4 associated factor 17
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM1 dynamin 1
ETAA1 Ewing tumor-associated antigen 1
FBXO31 F-box protein 31
FOXC1 forkhead box C1
FOXD1 forkhead box D1
FUZ fuzzy planar cell polarity protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPATCH3 G patch domain containing 3
GPR27 G protein-coupled receptor 27
GPX2 glutathione peroxidase 2
HDAC4 histone deacetylase 4
HIST1H2AG histone cluster 1, H2ag
HTRA1 HtrA serine peptidase 1
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
IMPACT impact RWD domain protein
INCENP inner centromere protein antigens 135/155kDa
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
LOC642236 FSHD region gene 1 pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBOAT2 membrane bound O-acyltransferase domain containing 2
MBTD1 mbt domain containing 1
MCMBP minichromosome maintenance complex binding protein
METTL8 methyltransferase like 8
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MXD3 MAX dimerization protein 3
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NECAB3 N-terminal EF-hand calcium binding protein 3
NLRX1 NLR family member X1
NT5DC3 5'-nucleotidase domain containing 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PDGFRL platelet-derived growth factor receptor-like
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PER3 period circadian clock 3
PEX26 peroxisomal biogenesis factor 26
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEK2 pleckstrin 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPT2 palmitoyl-protein thioesterase 2
PRICKLE3 prickle homolog 3 (Drosophila)
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPRU protein tyrosine phosphatase, receptor type, U
PVRL3 poliovirus receptor-related 3
PYCRL pyrroline-5-carboxylate reductase-like
SAV1 salvador family WW domain containing protein 1
SOX12 SRY (sex determining region Y)-box 12
SPINK4 serine peptidase inhibitor, Kazal type 4
STAG3 stromal antigen 3
TCTN1 tectonic family member 1
THRAP3 thyroid hormone receptor associated protein 3
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
TSPYL2 TSPY-like 2
TTC33 tetratricopeptide repeat domain 33
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF219 zinc finger protein 219
ZNF226 zinc finger protein 226
ZNF254 zinc finger protein 254
ZNF273 zinc finger protein 273
ZNF280D zinc finger protein 280D
ZNF324 zinc finger protein 324
ZNF365 zinc finger protein 365
ZNF768 zinc finger protein 768