penbutolol-3534 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the penbutolol-3534 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1A adrenoceptor alpha 1A
ADRA1D adrenoceptor alpha 1D
AKR1C1 aldo-keto reductase family 1, member C1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATN1 atrophin 1
ATXN3 ataxin 3
BCAP29 B-cell receptor-associated protein 29
BHLHE41 basic helix-loop-helix family, member e41
BNC2 basonuclin 2
C1ORF54 chromosome 1 open reading frame 54
CCDC28B coiled-coil domain containing 28B
CDC25C cell division cycle 25C
CDKN2A cyclin-dependent kinase inhibitor 2A
CFHR4 complement factor H-related 4
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DOC2B double C2-like domains, beta
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
ELMO2 engulfment and cell motility 2
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ETV4 ets variant 4
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP10 FK506 binding protein 10, 65 kDa
FLOT1 flotillin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALR3 galanin receptor 3
GOSR2 golgi SNAP receptor complex member 2
HEG1 heart development protein with EGF-like domains 1
HIST1H4C histone cluster 1, H4c
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
ICAM1 intercellular adhesion molecule 1
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT140 intraflagellar transport 140
INHBE inhibin, beta E
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1107 KIAA1107
KLHL22 kelch-like family member 22
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NCR2 natural cytotoxicity triggering receptor 2
NEB nebulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPEPL1 aminopeptidase-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
ORAI2 ORAI calcium release-activated calcium modulator 2
PAPOLA poly(A) polymerase alpha
PHF1 PHD finger protein 1
PHF14 PHD finger protein 14
PIDD1 p53-induced death domain protein 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR4 proline rich 4 (lacrimal)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN1 Ras and Rab interactor 1
RPS2 ribosomal protein S2
RPS3A ribosomal protein S3A
S100A11 S100 calcium binding protein A11
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SETD1A SET domain containing 1A
SLC35E2 solute carrier family 35, member E2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SPEG SPEG complex locus
SQLE squalene epoxidase
STAT2 signal transducer and activator of transcription 2, 113kDa
STRN striatin, calmodulin binding protein
SYCE1L synaptonemal complex central element protein 1-like
TBC1D17 TBC1 domain family, member 17
TGIF1 TGFB-induced factor homeobox 1
TJAP1 tight junction associated protein 1 (peripheral)
TMEM259 transmembrane protein 259
TMEM63A transmembrane protein 63A
TNXB tenascin XB
TREX1 three prime repair exonuclease 1
UPK2 uroplakin 2
ZNF609 zinc finger protein 609
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANXA2P3 annexin A2 pseudogene 3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAG4 BCL2-associated athanogene 4
C1ORF35 chromosome 1 open reading frame 35
CASZ1 castor zinc finger 1
CCDC121 coiled-coil domain containing 121
CLDN15 claudin 15
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DAGLA diacylglycerol lipase, alpha
EN2 engrailed homeobox 2
EPHA2 EPH receptor A2
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM118A family with sequence similarity 118, member A
FLNC filamin C, gamma
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP1 ganglioside induced differentiation associated protein 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1E histone cluster 1, H1e
HIST1H2AI histone cluster 1, H2ai
KIAA0319L KIAA0319-like
LHX6 LIM homeobox 6
LOC730101 uncharacterized LOC730101
MAGOH2P mago-nashi homolog 2, pseudogene
MAP6D1 MAP6 domain containing 1
MBTD1 mbt domain containing 1
MCC mutated in colorectal cancers
MFAP2 microfibrillar-associated protein 2
MGC12488
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
NPFFR1 neuropeptide FF receptor 1
NPTX1 neuronal pentraxin I
NUP62CL nucleoporin 62kDa C-terminal like
ODF2 outer dense fiber of sperm tails 2
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
PALM paralemmin
PAQR6 progestin and adipoQ receptor family member VI
PC pyruvate carboxylase
PCDHA9 protocadherin alpha 9
PDIA3 protein disulfide isomerase family A, member 3
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POPDC3 popeye domain containing 3
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
PRR14L proline rich 14-like
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RUNDC3B RUN domain containing 3B
RUSC2 RUN and SH3 domain containing 2
SCAI suppressor of cancer cell invasion
SCRN3 secernin 3
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC41A3 solute carrier family 41, member 3
SOX12 SRY (sex determining region Y)-box 12
STIM1 stromal interaction molecule 1
STXBP2 syntaxin binding protein 2
SULT4A1 sulfotransferase family 4A, member 1
TAOK1 TAO kinase 1
TMEM121 transmembrane protein 121
TMEM45A transmembrane protein 45A
TRAIP TRAF interacting protein
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSC22D4 TSC22 domain family, member 4
TUBA3D tubulin, alpha 3d
UBQLN4 ubiquilin 4
WDR76 WD repeat domain 76
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB22 zinc finger and BTB domain containing 22
ZNF324 zinc finger protein 324
ZNF639 zinc finger protein 639
ZNF652 zinc finger protein 652
ZNF696 zinc finger protein 696
ZNF721 zinc finger protein 721