partial lethality throughout fetal growth and development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) (Mammalian Phenotype Ontology, MP_0011109)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011109
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Genes

174 gene mutations causing the partial lethality throughout fetal growth and development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACO1 aconitase 1, soluble
ACTC1 actin, alpha, cardiac muscle 1
ADAM17 ADAM metallopeptidase domain 17
AIP aryl hydrocarbon receptor interacting protein
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ARF6 ADP-ribosylation factor 6
ASXL1 additional sex combs like transcriptional regulator 1
ATE1 arginyltransferase 1
B9D1 B9 protein domain 1
BAG6 BCL2-associated athanogene 6
BICC1 BicC family RNA binding protein 1
BIRC6 baculoviral IAP repeat containing 6
BMP4 bone morphogenetic protein 4
BRCA2 breast cancer 2, early onset
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CARM1 coactivator-associated arginine methyltransferase 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD274 CD274 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHD7 chromodomain helicase DNA binding protein 7
CHRD chordin
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CLEC1B C-type lectin domain family 1, member B
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK1D casein kinase 1, delta
CUL4B cullin 4B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAAM1 dishevelled associated activator of morphogenesis 1
DOCK1 dedicator of cytokinesis 1
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV5 ets variant 5
F11R F11 receptor
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
FBXL20 F-box and leucine-rich repeat protein 20
FBXW8 F-box and WD repeat domain containing 8
FES FES proto-oncogene, tyrosine kinase
FGF19 fibroblast growth factor 19
FGFR1 fibroblast growth factor receptor 1
FGFRL1 fibroblast growth factor receptor-like 1
FKBP1A FK506 binding protein 1A, 12kDa
FLNA filamin A, alpha
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXB1 forkhead box B1
FOXJ1 forkhead box J1
FOXP1 forkhead box P1
FOXQ1 forkhead box Q1
FRAS1 Fraser extracellular matrix complex subunit 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GDF1 growth differentiation factor 1
GGCX gamma-glutamyl carboxylase
GJA1 gap junction protein, alpha 1, 43kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXA13 homeobox A13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HTT huntingtin
IFT140 intraflagellar transport 140
IFT88 intraflagellar transport 88
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JARID2 jumonji, AT rich interactive domain 2
KDM2B lysine (K)-specific demethylase 2B
KITLG KIT ligand
KLF3 Kruppel-like factor 3 (basic)
LARP7 La ribonucleoprotein domain family, member 7
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG4 ligase IV, DNA, ATP-dependent
LRP1 low density lipoprotein receptor-related protein 1
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKL2 MKL/myocardin-like 2
MKS1 Meckel syndrome, type 1
MYH10 myosin, heavy chain 10, non-muscle
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK7 NIMA-related kinase 7
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L1 nuclear factor, erythroid 2-like 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUAK2 NUAK family, SNF1-like kinase, 2
OVOL1 ovo-like zinc finger 1
OXSR1 oxidative stress responsive 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX2 paired box 2
PAX3 paired box 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PDS5B PDS5 cohesin associated factor B
PHACTR4 phosphatase and actin regulator 4
PHF13 PHD finger protein 13
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PON3 paraoxonase 3
POR P450 (cytochrome) oxidoreductase
PRDM1 PR domain containing 1, with ZNF domain
PRKD1 protein kinase D1
PTCH1 patched 1
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAD50 RAD50 homolog (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RAI1 retinoic acid induced 1
RAP1B RAP1B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCE1 Ras converting CAAX endopeptidase 1
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RTL1 retrotransposon-like 1
RXRA retinoid X receptor, alpha
RYR2 ryanodine receptor 2 (cardiac)
SALL4 spalt-like transcription factor 4
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SENP1 SUMO1/sentrin specific peptidase 1
SHH sonic hedgehog
SHOX2 short stature homeobox 2
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SLX4 SLX4 structure-specific endonuclease subunit
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
SP2 Sp2 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
SRSF10 serine/arginine-rich splicing factor 10
SSBP3 single stranded DNA binding protein 3
STX1A syntaxin 1A (brain)
SUMO1 small ubiquitin-like modifier 1
TAL1 T-cell acute lymphocytic leukemia 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TH tyrosine hydroxylase
TLE3 transducin-like enhancer of split 3
TLL1 tolloid-like 1
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIO trio Rho guanine nucleotide exchange factor
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TSC2 tuberous sclerosis 2
TSTA3 tissue specific transplantation antigen P35B
UBE2L3 ubiquitin-conjugating enzyme E2L 3
VEZF1 vascular endothelial zinc finger 1
WNT1 wingless-type MMTV integration site family, member 1
YBX1 Y box binding protein 1
YY1 YY1 transcription factor
ZFP57 ZFP57 zinc finger protein
ZFPM1 zinc finger protein, FOG family member 1