partial embryonic lethality during organogenesis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) (Mammalian Phenotype Ontology, MP_0011108)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011108
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Genes

229 gene mutations causing the partial embryonic lethality during organogenesis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADRBK1 adrenergic, beta, receptor kinase 1
AFF4 AF4/FMR2 family, member 4
AIP aryl hydrocarbon receptor interacting protein
AMBRA1 autophagy/beclin-1 regulator 1
AMN amnion associated transmembrane protein
AMOT angiomotin
ANGPTL6 angiopoietin-like 6
APOB apolipoprotein B
ARID3A AT rich interactive domain 3A (BRIGHT-like)
AXIN2 axin 2
BBS1 Bardet-Biedl syndrome 1
BBS4 Bardet-Biedl syndrome 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP4 bone morphogenetic protein 4
BMP8B bone morphogenetic protein 8b
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
BRD1 bromodomain containing 1
C1GALT1C1 C1GALT1-specific chaperone 1
CAPNS1 calpain, small subunit 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CEP41 centrosomal protein 41kDa
CHD7 chromodomain helicase DNA binding protein 7
CIAPIN1 cytokine induced apoptosis inhibitor 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLUAP1 clusterin associated protein 1
COMMD1 copper metabolism (Murr1) domain containing 1
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DICER1 dicer 1, ribonuclease type III
DLL4 delta-like 4 (Drosophila)
DNM1L dynamin 1-like
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPH1 diphthamide biosynthesis 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DZIP1 DAZ interacting zinc finger protein 1
E2F3 E2F transcription factor 3
ECE1 endothelin converting enzyme 1
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ERF Ets2 repressor factor
ETV6 ets variant 6
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FBN1 fibrillin 1
FBXW8 F-box and WD repeat domain containing 8
FGFR1 fibroblast growth factor receptor 1
FLNB filamin B, beta
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT1 fms-related tyrosine kinase 1
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FN1 fibronectin 1
FOXC2 forkhead box C2
FOXI3 forkhead box I3
FOXP4 forkhead box P4
FOXQ1 forkhead box Q1
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCK glucokinase (hexokinase 4)
GCM2 glial cells missing homolog 2 (Drosophila)
GJB3 gap junction protein, beta 3, 31kDa
GLI3 GLI family zinc finger 3
GLRX3 glutaredoxin 3
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRHL2 grainyhead-like 2 (Drosophila)
GRIP1 glutamate receptor interacting protein 1
HAND1 heart and neural crest derivatives expressed 1
HDAC2 histone deacetylase 2
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMGN1 high mobility group nucleosome binding domain 1
HOPX HOP homeobox
HOXA13 homeobox A13
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPG2 heparan sulfate proteoglycan 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
IHH indian hedgehog
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INSM1 insulinoma-associated 1
INTU inturned planar cell polarity protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA7 integrin, alpha 7
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB8 integrin, beta 8
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
JUP junction plakoglobin
KAT2A K(lysine) acetyltransferase 2A
KDM6A lysine (K)-specific demethylase 6A
KDM8 lysine (K)-specific demethylase 8
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT8 keratin 8, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBX1 ladybird homeobox 1
LCMT1 leucine carboxyl methyltransferase 1
LDHA lactate dehydrogenase A
LEFTY1 left-right determination factor 1
LHX1 LIM homeobox 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MB myoglobin
MDFI MyoD family inhibitor
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MFN1 mitofusin 1
MFN2 mitofusin 2
MKS1 Meckel syndrome, type 1
MTTP microsomal triglyceride transfer protein
NACA nascent polypeptide-associated complex alpha subunit
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOA6 nuclear receptor coactivator 6
NEK7 NIMA-related kinase 7
NELFB negative elongation factor complex member B
NES nestin
NODAL nodal growth differentiation factor
NR2C2 nuclear receptor subfamily 2, group C, member 2
OSR1 odd-skipped related transciption factor 1
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX3 paired box 3
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPN podoplanin
PEG3 paternally expressed 3
PHACTR4 phosphatase and actin regulator 4
PHF13 PHD finger protein 13
PHOX2B paired-like homeobox 2b
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITX1 paired-like homeodomain 1
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PON3 paraoxonase 3
POU2F1 POU class 2 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PRDM6 PR domain containing 6
PRKCI protein kinase C, iota
PRKD1 protein kinase D1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB23 RAB23, member RAS oncogene family
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBMS1 RNA binding motif, single stranded interacting protein 1
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RLIM ring finger protein, LIM domain interacting
SAFB scaffold attachment factor B
SALL1 spalt-like transcription factor 1
SALL4 spalt-like transcription factor 4
SCRIB scribbled planar cell polarity protein
SECISBP2 SECIS binding protein 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SHH sonic hedgehog
SHOX2 short stature homeobox 2
SIRT1 sirtuin 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SMN1 survival of motor neuron 1, telomeric
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOX7 SRY (sex determining region Y)-box 7
SPTAN1 spectrin, alpha, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SSBP3 single stranded DNA binding protein 3
STAG1 stromal antigen 1
SULF2 sulfatase 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
T T, brachyury homolog (mouse)
TBP TATA box binding protein
TBX2 T-box 2
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGIF1 TGFB-induced factor homeobox 1
TH tyrosine hydroxylase
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM14C transmembrane protein 14C
TMSB4X thymosin beta 4, X-linked
TNRC6A trinucleotide repeat containing 6A
TP53 tumor protein p53
TRA2B transformer 2 beta homolog (Drosophila)
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TSC2 tuberous sclerosis 2
TSTA3 tissue specific transplantation antigen P35B
TTN titin
UBC ubiquitin C
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
WNT11 wingless-type MMTV integration site family, member 11
WNT3A wingless-type MMTV integration site family, member 3A
WT1 Wilms tumor 1
XPA xeroderma pigmentosum, complementation group A
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZFP36L1 ZFP36 ring finger protein-like 1
ZFPM1 zinc finger protein, FOG family member 1