paroxetine-4378 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the paroxetine-4378 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
AHCYL1 adenosylhomocysteinase-like 1
AKAP1 A kinase (PRKA) anchor protein 1
ALK anaplastic lymphoma receptor tyrosine kinase
APOC1 apolipoprotein C-I
ART1 ADP-ribosyltransferase 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C1ORF95 chromosome 1 open reading frame 95
C7ORF69 chromosome 7 open reading frame 69
CA5B carbonic anhydrase VB, mitochondrial
CADM4 cell adhesion molecule 4
CCDC57 coiled-coil domain containing 57
CCDC7 coiled-coil domain containing 7
CD47 CD47 molecule
CDK13 cyclin-dependent kinase 13
CEMP1 cementum protein 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA1 chloride channel accessory 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DMWD dystrophia myotonica, WD repeat containing
DOK4 docking protein 4
DTNA dystrobrevin, alpha
EMID1 EMI domain containing 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM182B family with sequence similarity 182, member B
FASLG Fas ligand (TNF superfamily, member 6)
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GK glycerol kinase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GUCA1A guanylate cyclase activator 1A (retina)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL1RL2 interleukin 1 receptor-like 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KDM5A lysine (K)-specific demethylase 5A
KIAA0754 KIAA0754
KRT32 keratin 32, type I
LAMC3 laminin, gamma 3
LAT2 linker for activation of T cells family, member 2
LDHC lactate dehydrogenase C
LINC00260 long intergenic non-protein coding RNA 260
LMAN1 lectin, mannose-binding, 1
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
LRRK1 leucine-rich repeat kinase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MST1 macrophage stimulating 1
MTMR3 myotubularin related protein 3
MXD4 MAX dimerization protein 4
NEUROD6 neuronal differentiation 6
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPTX2 neuronal pentraxin II
OR1E1 olfactory receptor, family 1, subfamily E, member 1
OSBPL10 oxysterol binding protein-like 10
PCDHGA8 protocadherin gamma subfamily A, 8
PDE4C phosphodiesterase 4C, cAMP-specific
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PGPEP1 pyroglutamyl-peptidase I
PKD1 polycystic kidney disease 1 (autosomal dominant)
PNMAL1 paraneoplastic Ma antigen family-like 1
PTGDR2 prostaglandin D2 receptor 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAPCD1 suppressor APC domain containing 1
SFTPC surfactant protein C
SHOX2 short stature homeobox 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SORBS1 sorbin and SH3 domain containing 1
SOX15 SRY (sex determining region Y)-box 15
SYK spleen tyrosine kinase
TARP TCR gamma alternate reading frame protein
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNPO2 transportin 2
TRD T cell receptor delta locus
TSC2 tuberous sclerosis 2
TTLL5 tubulin tyrosine ligase-like family member 5
XIST X inactive specific transcript (non-protein coding)
YOD1 YOD1 deubiquitinase
ZER1 zyg-11 related, cell cycle regulator
ZNF682 zinc finger protein 682
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ADM adrenomedullin
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BIRC7 baculoviral IAP repeat containing 7
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C3 complement component 3
C5AR2 complement component 5a receptor 2
C8ORF44 chromosome 8 open reading frame 44
CBX2 chromobox homolog 2
CBX8 chromobox homolog 8
CCDC69 coiled-coil domain containing 69
CCNO cyclin O
CD70 CD70 molecule
CEL carboxyl ester lipase
CFHR4 complement factor H-related 4
CGA glycoprotein hormones, alpha polypeptide
CNTFR ciliary neurotrophic factor receptor
CSF1R colony stimulating factor 1 receptor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DLK2 delta-like 2 homolog (Drosophila)
DNASE1L2 deoxyribonuclease I-like 2
DUSP13 dual specificity phosphatase 13
ERO1LB ERO1-like beta (S. cerevisiae)
F9 coagulation factor IX
FRS2 fibroblast growth factor receptor substrate 2
FSHB follicle stimulating hormone, beta polypeptide
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GMPR guanosine monophosphate reductase
GRAMD1C GRAM domain containing 1C
GSTP1 glutathione S-transferase pi 1
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2BO histone cluster 1, H2bo
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFNA14 interferon, alpha 14
INPP5J inositol polyphosphate-5-phosphatase J
ISL1 ISL LIM homeobox 1
ITM2C integral membrane protein 2C
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KIAA1324 KIAA1324
KIAA1462 KIAA1462
KREMEN2 kringle containing transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LARP6 La ribonucleoprotein domain family, member 6
LGALS9 lectin, galactoside-binding, soluble, 9
LINC00341 long intergenic non-protein coding RNA 341
LYRM9 LYR motif containing 9
LZTR1 leucine-zipper-like transcription regulator 1
MGC2889 uncharacterized protein MGC2889
NEUROD1 neuronal differentiation 1
OLFML2A olfactomedin-like 2A
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIPOX pipecolic acid oxidase
PLA2G3 phospholipase A2, group III
PLEKHA6 pleckstrin homology domain containing, family A member 6
POU3F2 POU class 3 homeobox 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PROL1 proline rich, lacrimal 1
PTX3 pentraxin 3, long
PWAR5 Prader Willi/Angelman region RNA 5
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPA4 replication protein A4, 30kDa
SCARA3 scavenger receptor class A, member 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP4 STEAP family member 4
TAS2R10 taste receptor, type 2, member 10
TCTN2 tectonic family member 2
TEX14 testis expressed 14
TEX40 testis expressed 40
TM4SF4 transmembrane 4 L six family member 4
TM4SF5 transmembrane 4 L six family member 5
TMPRSS4 transmembrane protease, serine 4
TRIM68 tripartite motif containing 68
TRPM2 transient receptor potential cation channel, subfamily M, member 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF639 zinc finger protein 639