paromomycin-4420 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the paromomycin-4420 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM23 ADAM metallopeptidase domain 23
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADRA1D adrenoceptor alpha 1D
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ARHGAP28 Rho GTPase activating protein 28
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BCL2L10 BCL2-like 10 (apoptosis facilitator)
CCDC87 coiled-coil domain containing 87
CD6 CD6 molecule
CEP112 centrosomal protein 112kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIDEB cell death-inducing DFFA-like effector b
CLEC7A C-type lectin domain family 7, member A
CLSTN3 calsyntenin 3
CNPY4 canopy FGF signaling regulator 4
COL1A1 collagen, type I, alpha 1
COL8A2 collagen, type VIII, alpha 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSZ cathepsin Z
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYTH4 cytohesin 4
DAPK2 death-associated protein kinase 2
DLG4 discs, large homolog 4 (Drosophila)
DOPEY2 dopey family member 2
E2F2 E2F transcription factor 2
FAM163A family with sequence similarity 163, member A
FGL2 fibrinogen-like 2
FST follistatin
GGT1 gamma-glutamyltransferase 1
GM2A GM2 ganglioside activator
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR85 G protein-coupled receptor 85
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCRT hypocretin (orexin) neuropeptide precursor
HDLBP high density lipoprotein binding protein
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HOXA6 homeobox A6
IL36G interleukin 36, gamma
IVL involucrin
KIAA1109 KIAA1109
KLHDC8A kelch domain containing 8A
LARGE like-glycosyltransferase
LEFTY1 left-right determination factor 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMS2 LIM and senescent cell antigen-like domains 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LTBP4 latent transforming growth factor beta binding protein 4
LYZL6 lysozyme-like 6
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MCAM melanoma cell adhesion molecule
MPL MPL proto-oncogene, thrombopoietin receptor
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYO9B myosin IXB
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEFM neurofilament, medium polypeptide
NTF3 neurotrophin 3
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PLXNB1 plexin B1
POU2F2 POU class 2 homeobox 2
POU5F1B POU class 5 homeobox 1B
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RARA retinoic acid receptor, alpha
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIF1 replication timing regulatory factor 1
RIMS1 regulating synaptic membrane exocytosis 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SCAND2P SCAN domain containing 2 pseudogene
SCN10A sodium channel, voltage gated, type X alpha subunit
SELE selectin E
SH3BP1 SH3-domain binding protein 1
SHOX2 short stature homeobox 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SPRED2 sprouty-related, EVH1 domain containing 2
SPTB spectrin, beta, erythrocytic
SSX3 synovial sarcoma, X breakpoint 3
SYNDIG1 synapse differentiation inducing 1
TAS2R1 taste receptor, type 2, member 1
THY1 Thy-1 cell surface antigen
TM4SF5 transmembrane 4 L six family member 5
TNK2 tyrosine kinase, non-receptor, 2
TP63 tumor protein p63
TRPM2 transient receptor potential cation channel, subfamily M, member 2
VN1R1 vomeronasal 1 receptor 1
VNN1 vanin 1
WNT2B wingless-type MMTV integration site family, member 2B
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACTL8 actin-like 8
AFAP1 actin filament associated protein 1
AGMAT agmatine ureohydrolase (agmatinase)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARMC4 armadillo repeat containing 4
ATAD5 ATPase family, AAA domain containing 5
BAX BCL2-associated X protein
C11ORF30 chromosome 11 open reading frame 30
C19ORF73 chromosome 19 open reading frame 73
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCP110 centriolar coiled coil protein 110kDa
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP45 cilia and flagella associated protein 45
CHRM3 cholinergic receptor, muscarinic 3
CTSF cathepsin F
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
ERCC6 excision repair cross-complementation group 6
ETV6 ets variant 6
FAM204A family with sequence similarity 204, member A
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
FOXJ2 forkhead box J2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAMT guanidinoacetate N-methyltransferase
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIRA histone cell cycle regulator
HIST1H2BC histone cluster 1, H2bc
HOXB2 homeobox B2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT22 intraflagellar transport 22
IPO8 importin 8
IRF9 interferon regulatory factor 9
KIAA0895 KIAA0895
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT24 keratin 24, type I
LHX6 LIM homeobox 6
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LOC157562 uncharacterized LOC157562
MBTD1 mbt domain containing 1
MEGF6 multiple EGF-like-domains 6
MRPL52 mitochondrial ribosomal protein L52
NBEA neurobeachin
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NRSN2 neurensin 2
OLFML2A olfactomedin-like 2A
PHC1 polyhomeotic homolog 1 (Drosophila)
PHEX phosphate regulating endopeptidase homolog, X-linked
PITX2 paired-like homeodomain 2
PLCD1 phospholipase C, delta 1
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
PROS1 protein S (alpha)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKI SKI proto-oncogene
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPIDR scaffolding protein involved in DNA repair
SPINK4 serine peptidase inhibitor, Kazal type 4
SREK1IP1 SREK1-interacting protein 1
STRA6 stimulated by retinoic acid 6
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TM6SF1 transmembrane 6 superfamily member 1
TMEM120B transmembrane protein 120B
TPSG1 tryptase gamma 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM36 tripartite motif containing 36
TSGA10 testis specific, 10
TTC17 tetratricopeptide repeat domain 17
VEZT vezatin, adherens junctions transmembrane protein
VLDLR very low density lipoprotein receptor
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR33 WD repeat domain 33
ZNF286A zinc finger protein 286A
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675