parbendazole-4535 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the parbendazole-4535 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACOT11 acyl-CoA thioesterase 11
AGFG1 ArfGAP with FG repeats 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBC3 BCL2 binding component 3
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
C17ORF53 chromosome 17 open reading frame 53
C20ORF195 chromosome 20 open reading frame 195
C4ORF19 chromosome 4 open reading frame 19
CALD1 caldesmon 1
CAPN10 calpain 10
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK6 cyclin-dependent kinase 6
CLCN7 chloride channel, voltage-sensitive 7
CLDN1 claudin 1
CLTCL1 clathrin, heavy chain-like 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPZ carboxypeptidase Z
CTBP2 C-terminal binding protein 2
CTNS cystinosin, lysosomal cystine transporter
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAAM2 dishevelled associated activator of morphogenesis 2
DSTYK dual serine/threonine and tyrosine protein kinase
DUOX2 dual oxidase 2
E2F4 E2F transcription factor 4, p107/p130-binding
EIF4A1 eukaryotic translation initiation factor 4A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
F13B coagulation factor XIII, B polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF5 fibroblast growth factor 5
GAL galanin/GMAP prepropeptide
GMPR guanosine monophosphate reductase
GRM8 glutamate receptor, metabotropic 8
GSDMB gasdermin B
GSK3A glycogen synthase kinase 3 alpha
GTSE1 G-2 and S-phase expressed 1
HIST1H3I histone cluster 1, H3i
HOXA11 homeobox A11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
ING4 inhibitor of growth family, member 4
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
JADE2 jade family PHD finger 2
JAK2 Janus kinase 2
KIAA1456 KIAA1456
LPCAT4 lysophosphatidylcholine acyltransferase 4
MBD2 methyl-CpG binding domain protein 2
MLXIP MLX interacting protein
MT1M metallothionein 1M
MYRIP myosin VIIA and Rab interacting protein
NAV2 neuron navigator 2
NEUROD1 neuronal differentiation 1
OLFM4 olfactomedin 4
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCDHGA10 protocadherin gamma subfamily A, 10
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PER1 period circadian clock 1
PKNOX1 PBX/knotted 1 homeobox 1
POFUT1 protein O-fucosyltransferase 1
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PROX1 prospero homeobox 1
PTK6 protein tyrosine kinase 6
PTPRR protein tyrosine phosphatase, receptor type, R
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RBM48 RNA binding motif protein 48
RDX radixin
REPS1 RALBP1 associated Eps domain containing 1
RHEB Ras homolog enriched in brain
RIMS3 regulating synaptic membrane exocytosis 3
RNF6 ring finger protein (C3H2C3 type) 6
RPL10L ribosomal protein L10-like
RUNX1 runt-related transcription factor 1
SAYSD1 SAYSVFN motif domain containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX21 SRY (sex determining region Y)-box 21
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK24 serine/threonine kinase 24
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNIK TRAF2 and NCK interacting kinase
TREM2 triggering receptor expressed on myeloid cells 2
TTN titin
TUBA4B tubulin, alpha 4b
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF235 zinc finger protein 235
ZNF3 zinc finger protein 3
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM2 ADAM metallopeptidase domain 2
AKAP5 A kinase (PRKA) anchor protein 5
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB2 arrestin, beta 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAAT bile acid CoA:amino acid N-acyltransferase
BATF3 basic leucine zipper transcription factor, ATF-like 3
BTF3P12 basic transcription factor 3 pseudogene 12
C5ORF42 chromosome 5 open reading frame 42
C7ORF69 chromosome 7 open reading frame 69
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CCNJL cyclin J-like
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD101 CD101 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CREB5 cAMP responsive element binding protein 5
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSO cathepsin O
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
EGR2 early growth response 2
FAM192A family with sequence similarity 192, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXC1 forkhead box C1
GJA8 gap junction protein, alpha 8, 50kDa
HIST1H2AK histone cluster 1, H2ak
HIST1H3G histone cluster 1, H3g
HIST1H4D histone cluster 1, H4d
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
HOXA6 homeobox A6
IL1B interleukin 1, beta
INPPL1 inositol polyphosphate phosphatase-like 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRF1 interferon regulatory factor 1
ITPKA inositol-trisphosphate 3-kinase A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM7A lysine (K)-specific demethylase 7A
KDM8 lysine (K)-specific demethylase 8
KRT86 keratin 86, type II
LAX1 lymphocyte transmembrane adaptor 1
LIME1 Lck interacting transmembrane adaptor 1
LPAR6 lysophosphatidic acid receptor 6
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP5L low density lipoprotein receptor-related protein 5-like
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MCC mutated in colorectal cancers
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MX1 MX dynamin-like GTPase 1
MYLIP myosin regulatory light chain interacting protein
NDP Norrie disease (pseudoglioma)
NOD1 nucleotide-binding oligomerization domain containing 1
NT5M 5',3'-nucleotidase, mitochondrial
NXPH4 neurexophilin 4
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSMR oncostatin M receptor
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
PPP1R3D protein phosphatase 1, regulatory subunit 3D
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF122 ring finger protein 122
SAMD9 sterile alpha motif domain containing 9
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMR3A submaxillary gland androgen regulated protein 3A
SOD3 superoxide dismutase 3, extracellular
SPEG SPEG complex locus
STAG3 stromal antigen 3
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TCTN2 tectonic family member 2
TEP1 telomerase-associated protein 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM25 tripartite motif containing 25
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TUBB2B tubulin, beta 2B class IIb
TXLNG taxilin gamma
USP20 ubiquitin specific peptidase 20
WDR76 WD repeat domain 76
YY2 YY2 transcription factor
ZNF230 zinc finger protein 230
ZNF529 zinc finger protein 529
ZNF702P zinc finger protein 702, pseudogene
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2