panic disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. (Human Disease Ontology, DOID_594)
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Genes

175 genes co-occuring with the disease panic disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PTK7 protein tyrosine kinase 7 (inactive) 2.76474
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.04191
CCKBR cholecystokinin B receptor 2.02295
CCK cholecystokinin 1.99872
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.9136
MAOA monoamine oxidase A 1.72958
CRH corticotropin releasing hormone 1.6077
NPSR1 neuropeptide S receptor 1 1.60055
USP39 ubiquitin specific peptidase 39 1.53833
COMT catechol-O-methyltransferase 1.49218
POMC proopiomelanocortin 1.38647
TPH2 tryptophan hydroxylase 2 1.35507
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.33589
DEAF1 DEAF1 transcription factor 1.33109
RGS2 regulator of G-protein signaling 2 1.29833
OR13H1 olfactory receptor, family 13, subfamily H, member 1 1.26821
TMEM132D transmembrane protein 132D 1.24645
CRHR1 corticotropin releasing hormone receptor 1 1.22042
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.18841
TMEM132E transmembrane protein 132E 1.1841
NPS neuropeptide S 1.17378
CCKAR cholecystokinin A receptor 1.12783
TPH1 tryptophan hydroxylase 1 1.07908
CRHR2 corticotropin releasing hormone receptor 2 1.06438
ADORA2A adenosine A2a receptor 1.05723
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 1.03872
CALCOCO1 calcium binding and coiled-coil domain 1 1.03367
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.0324
BPI bactericidal/permeability-increasing protein 1.02229
ANO2 anoctamin 2, calcium activated chloride channel 0.990644
BDNF brain-derived neurotrophic factor 0.966663
SDK2 sidekick cell adhesion molecule 2 0.905675
NPY5R neuropeptide Y receptor Y5 0.89582
TMEM98 transmembrane protein 98 0.889258
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.859362
MEA1 male-enhanced antigen 1 0.858134
TRH thyrotropin-releasing hormone 0.850354
HCRT hypocretin (orexin) neuropeptide precursor 0.836837
APOL3 apolipoprotein L, 3 0.831099
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.821257
ABAT 4-aminobutyrate aminotransferase 0.820847
ADAD2 adenosine deaminase domain containing 2 0.819616
GRIK5 glutamate receptor, ionotropic, kainate 5 0.818385
TRIP12 thyroid hormone receptor interactor 12 0.817565
EFHC2 EF-hand domain (C-terminal) containing 2 0.811411
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.808539
FOS FBJ murine osteosarcoma viral oncogene homolog 0.796642
HCRTR2 hypocretin (orexin) receptor 2 0.778613
NPY neuropeptide Y 0.770844
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.765943
OPRK1 opioid receptor, kappa 1 0.765535
DRD1 dopamine receptor D1 0.761862
GPM6A glycoprotein M6A 0.726524
MYDGF myeloid-derived growth factor 0.722886
KCTD5 potassium channel tetramerization domain containing 5 0.716021
DAOA D-amino acid oxidase activator 0.714811
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.702732
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.692697
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.684692
AADACL3 arylacetamide deacetylase-like 3 0.670333
HES5 hes family bHLH transcription factor 5 0.662784
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.66199
APOL2 apolipoprotein L, 2 0.654067
CREM cAMP responsive element modulator 0.638676
NTF3 neurotrophin 3 0.62885
MIR22 microRNA 22 0.626495
GRPR gastrin-releasing peptide receptor 0.619834
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.615138
RGS17 regulator of G-protein signaling 17 0.612011
RGS7 regulator of G-protein signaling 7 0.610448
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.606543
LSAMP limbic system-associated membrane protein 0.605762
CC2D1A coiled-coil and C2 domain containing 1A 0.60147
GHRH growth hormone releasing hormone 0.591727
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.587444
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.574994
MANEA mannosidase, endo-alpha 0.57305
CORT cortistatin 0.566831
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.561004
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.559839
DRD4 dopamine receptor D4 0.53928
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.534635
SEPT11 septin 11 0.524974
AVPR1B arginine vasopressin receptor 1B 0.524588
SERP1 stress-associated endoplasmic reticulum protein 1 0.502292
DRD2 dopamine receptor D2 0.500761
PRLH prolactin releasing hormone 0.495411
AVPR1A arginine vasopressin receptor 1A 0.487407
JMJD6 jumonji domain containing 6 0.475255
BDKRB2 bradykinin receptor B2 0.472604
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.46655
MEGF6 multiple EGF-like-domains 6 0.464283
HCRTR1 hypocretin (orexin) receptor 1 0.461639
PHGDH phosphoglycerate dehydrogenase 0.461639
TSPO translocator protein (18kDa) 0.449947
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.448817
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.447687
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.446935
TAS1R3 taste receptor, type 1, member 3 0.431894
GRM8 glutamate receptor, metabotropic 8 0.430017
GRM7 glutamate receptor, metabotropic 7 0.428516
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.421765
GRM2 glutamate receptor, metabotropic 2 0.415398
PNOC prepronociceptin 0.404931
AMY1A amylase, alpha 1A (salivary) 0.398589
AMY1B amylase, alpha 1B (salivary) 0.398589
AMY1C amylase, alpha 1C (salivary) 0.398589
ASIC2 acid sensing (proton gated) ion channel 2 0.395235
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.386308
PNMT phenylethanolamine N-methyltransferase 0.38111
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.379997
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.368149
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.367779
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.364454
NPPA natriuretic peptide A 0.36187
ORM1 orosomucoid 1 0.357814
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.356341
PKP1 plakophilin 1 0.350452
NPY1R neuropeptide Y receptor Y1 0.349717
UCN urocortin 0.336876
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.334315
TRDN triadin 0.334315
GHRL ghrelin/obestatin prepropeptide 0.32701
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.324094
CTNND2 catenin (cadherin-associated protein), delta 2 0.321545
DRD3 dopamine receptor D3 0.312464
UST uronyl-2-sulfotransferase 0.309204
NBPF8 neuroblastoma breakpoint family, member 8 0.305226
PARG poly (ADP-ribose) glycohydrolase 0.302337
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.295492
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.28616
DCXR dicarbonyl/L-xylulose reductase 0.283655
AKR1C1 aldo-keto reductase family 1, member C1 0.281153
GRIK1 glutamate receptor, ionotropic, kainate 1 0.279724
SIM2 single-minded family bHLH transcription factor 2 0.27794
NMS neuromedin S 0.277227
HINT1 histidine triad nucleotide binding protein 1 0.264077
PDE4B phosphodiesterase 4B, cAMP-specific 0.261245
TACR1 tachykinin receptor 1 0.259477
TMEM51 transmembrane protein 51 0.255594
DRD5 dopamine receptor D5 0.250663
SLC45A2 solute carrier family 45, member 2 0.242945
NPR3 natriuretic peptide receptor 3 0.242245
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.23945
GRM5 glutamate receptor, metabotropic 5 0.238752
OPRL1 opiate receptor-like 1 0.233878
SIGLEC10 sialic acid binding Ig-like lectin 10 0.233183
PREB prolactin regulatory element binding 0.233183
PPCS phosphopantothenoylcysteine synthetase 0.232836
REST RE1-silencing transcription factor 0.231102
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.224884
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.219398
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.218374
CLU clusterin 0.215992
MASP2 mannan-binding lectin serine peptidase 2 0.213283
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.207912
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.206913
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.20658
PSAP prosaposin 0.202618
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.201962
GAL galanin/GMAP prepropeptide 0.201308
DAO D-amino-acid oxidase 0.200656
EED embryonic ectoderm development 0.191719
BOC BOC cell adhesion associated, oncogene regulated 0.190476
TAC1 tachykinin, precursor 1 0.189551
SIX5 SIX homeobox 5 0.179802
ADA adenosine deaminase 0.178403
ASIC1 acid sensing (proton gated) ion channel 1 0.174881
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.170789
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.166544
DTNBP1 dystrobrevin binding protein 1 0.165217
CTSC cathepsin C 0.163317
LST1 leukocyte specific transcript 1 0.162505
PIDD1 p53-induced death domain protein 1 0.161331
MID2 midline 2 0.15948