pancreatic alpha cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description One of the cells in the periphery of the pancreatic islets that secrete somatostatin (alpha1 cells) and glucagon (alpha2 cells). (BRENDA Tissue and Enzyme Source Ontology, BTO_0000990)
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Genes

169 proteins co-occuring with the tissue pancreatic alpha cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
GCG glucagon 3.50622
INS insulin 2.58845
SST somatostatin 1.80006
PPY pancreatic polypeptide 1.76927
PAX4 paired box 4 1.72484
GCGR glucagon receptor 1.66657
IAPP islet amyloid polypeptide 1.51997
GIP gastric inhibitory polypeptide 1.38459
NEUROG3 neurogenin 3 1.36359
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.35268
DPP4 dipeptidyl-peptidase 4 1.33319
PAX6 paired box 6 1.33184
GLP1R glucagon-like peptide 1 receptor 1.3228
PCSK2 proprotein convertase subtilisin/kexin type 2 1.29489
POU3F4 POU class 3 homeobox 4 1.25324
PDX1 pancreatic and duodenal homeobox 1 1.14919
NKX2-2 NK2 homeobox 2 1.11951
PCSK1 proprotein convertase subtilisin/kexin type 1 1.08325
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 1.06118
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.02206
ARX aristaless related homeobox 1.019
CDX2 caudal type homeobox 2 0.974583
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.966793
RAD52 RAD52 homolog (S. cerevisiae) 0.924623
GCK glucokinase (hexokinase 4) 0.899871
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.853788
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.847904
MRPS31 mitochondrial ribosomal protein S31 0.791877
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.785635
NEUROD1 neuronal differentiation 1 0.778986
DMBT1 deleted in malignant brain tumors 1 0.772759
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.768197
HMX1 H6 family homeobox 1 0.756604
NKX6-1 NK6 homeobox 1 0.712959
FAM3B family with sequence similarity 3, member B 0.688409
ISL1 ISL LIM homeobox 1 0.67821
SYTL4 synaptotagmin-like 4 0.674543
CLSTN3 calsyntenin 3 0.640023
CPE carboxypeptidase E 0.635976
PDZD2 PDZ domain containing 2 0.633953
CHGA chromogranin A 0.63274
SCG5 secretogranin V 0.62991
GHRL ghrelin/obestatin prepropeptide 0.623043
BRSK1 BR serine/threonine kinase 1 0.622639
STC1 stanniocalcin 1 0.621024
METTL3 methyltransferase like 3 0.610541
NKX6-2 NK6 homeobox 2 0.610541
HMGN3 high mobility group nucleosomal binding domain 3 0.599273
INSR insulin receptor 0.589635
SSTR2 somatostatin receptor 2 0.577615
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) 0.557263
TAGAP T-cell activation RhoGTPase activating protein 0.554876
FOXA2 forkhead box A2 0.554876
GLP2R glucagon-like peptide 2 receptor 0.553286
GPR119 G protein-coupled receptor 119 0.539
SPO11 SPO11 meiotic protein covalently bound to DSB 0.538604
BTC betacellulin 0.530298
FOXM1 forkhead box M1 0.523588
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.512957
SLC30A4 solute carrier family 30 (zinc transporter), member 4 0.512564
PYY peptide YY 0.507457
ELSPBP1 epididymal sperm binding protein 1 0.503141
TIPRL TOR signaling pathway regulator 0.50275
HOXA6 homeobox A6 0.499615
SYTL2 synaptotagmin-like 2 0.495701
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.489838
GAN gigaxonin 0.489447
HNF1A HNF1 homeobox A 0.482428
CLSTN1 calsyntenin 1 0.478534
GRM8 glutamate receptor, metabotropic 8 0.476589
IRS2 insulin receptor substrate 2 0.475423
GAST gastrin 0.475034
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.4634
CHGB chromogranin B 0.444499
DGKB diacylglycerol kinase, beta 90kDa 0.437589
TLE2 transducin-like enhancer of split 2 0.436438
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.429165
WFS1 Wolfram syndrome 1 (wolframin) 0.42649
NRG4 neuregulin 4 0.423818
PC pyruvate carboxylase 0.410111
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.410111
KRT19 keratin 19, type I 0.409351
STX1A syntaxin 1A (brain) 0.408212
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.406694
GPM6A glycoprotein M6A 0.399871
PASK PAS domain containing serine/threonine kinase 0.3976
MNX1 motor neuron and pancreas homeobox 1 0.388535
HOXC10 homeobox C10 0.374243
GJD2 gap junction protein, delta 2, 36kDa 0.367876
FFAR1 free fatty acid receptor 1 0.366007
IL2RA interleukin 2 receptor, alpha 0.356314
NRD1 nardilysin (N-arginine dibasic convertase) 0.355942
CGB7 chorionic gonadotropin, beta polypeptide 7 0.35334
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.352227
MGLL monoglyceride lipase 0.350372
CGB5 chorionic gonadotropin, beta polypeptide 5 0.350001
DAGLA diacylglycerol lipase, alpha 0.34334
CGB chorionic gonadotropin, beta polypeptide 0.33413
CST1 cystatin SN 0.33413
CGB8 chorionic gonadotropin, beta polypeptide 8 0.333028
SOX4 SRY (sex determining region Y)-box 4 0.328994
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.326432
PTF1A pancreas specific transcription factor, 1a 0.32497
HNF4A hepatocyte nuclear factor 4, alpha 0.32497
IRS1 insulin receptor substrate 1 0.323144
GPER1 G protein-coupled estrogen receptor 1 0.317679
SYT3 synaptotagmin III 0.31332
MANBA mannosidase, beta A, lysosomal 0.308974
INSM2 insulinoma-associated 2 0.308612
STK39 serine threonine kinase 39 0.306083
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.302838
LEP leptin 0.301758
PCSK7 proprotein convertase subtilisin/kexin type 7 0.301398
ACPT acid phosphatase, testicular 0.29996
HOXC9 homeobox C9 0.295655
DNPEP aspartyl aminopeptidase 0.294939
ALOX12 arachidonate 12-lipoxygenase 0.293508
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.292079
GLB1 galactosidase, beta 1 0.292079
PFKP phosphofructokinase, platelet 0.289939
TLE3 transducin-like enhancer of split 3 0.28887
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.286381
IRX2 iroquois homeobox 2 0.285316
DNAH8 dynein, axonemal, heavy chain 8 0.284962
SYP synaptophysin 0.278955
RAB40AL RAB40A, member RAS oncogene family-like 0.270909
ACACA acetyl-CoA carboxylase alpha 0.270561
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.267446
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.266413
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.262986
SV2B synaptic vesicle glycoprotein 2B 0.262304
GSX1 GS homeobox 1 0.261964
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.261624
CDX4 caudal type homeobox 4 0.25858
SEPT5 septin 5 0.257907
PFKL phosphofructokinase, liver 0.256902
IRX1 iroquois homeobox 1 0.253248
OXR1 oxidation resistance 1 0.251279
DEAF1 DEAF1 transcription factor 0.249329
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.247399
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.243294
JMJD6 jumonji domain containing 6 0.242363
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.242363
GRM4 glutamate receptor, metabotropic 4 0.238108
IFNL2 interferon, lambda 2 0.236627
MSH4 mutS homolog 4 0.234016
STC2 stanniocalcin 2 0.233731
SPRY4 sprouty homolog 4 (Drosophila) 0.232599
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.230656
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.228497
KRT20 keratin 20, type I 0.22797
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.225647
SYT7 synaptotagmin VII 0.223906
TLE4 transducin-like enhancer of split 4 0.222938
CDC7 cell division cycle 7 0.22246
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.221755
FTO fat mass and obesity associated 0.219485
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.219047
HAP1 huntingtin-associated protein 1 0.217974
HOXB6 homeobox B6 0.217974
UNC13A unc-13 homolog A (C. elegans) 0.21365
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 0.199499
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.197476
NNAT neuronatin 0.197051
NIT1 nitrilase 1 0.1961
PBX1 pre-B-cell leukemia homeobox 1 0.19376
SI sucrase-isomaltase (alpha-glucosidase) 0.189151
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.186613
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.182173