pain disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress. (Human Disease Ontology, DOID_0060164)
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Genes

153 genes co-occuring with the disease pain disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.32
SCN11A sodium channel, voltage gated, type XI alpha subunit 1.59072
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.56978
SCN3A sodium channel, voltage gated, type III alpha subunit 1.56089
NGF nerve growth factor (beta polypeptide) 1.50096
CABIN1 calcineurin binding protein 1 1.45748
TAC1 tachykinin, precursor 1 1.29833
TRPA1 transient receptor potential cation channel, subfamily A, member 1 1.24776
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.18582
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.0244
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.02397
NME1-NME2 NME1-NME2 readthrough 1.01765
ARHGAP12 Rho GTPase activating protein 12 0.985164
TACR1 tachykinin receptor 1 0.94078
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.937459
PTS 6-pyruvoyltetrahydropterin synthase 0.893769
SCN10A sodium channel, voltage gated, type X alpha subunit 0.816745
SYNRG synergin, gamma 0.813873
HTRA1 HtrA serine peptidase 1 0.772479
NPS neuropeptide S 0.741923
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.728952
LIN7C lin-7 homolog C (C. elegans) 0.709169
BDNF brain-derived neurotrophic factor 0.693499
CCR2 chemokine (C-C motif) receptor 2 0.633169
UPK1B uroplakin 1B 0.627672
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.619442
ELP2 elongator acetyltransferase complex subunit 2 0.617094
AIF1 allograft inflammatory factor 1 0.603811
ADRA1D adrenoceptor alpha 1D 0.60147
KLK3 kallikrein-related peptidase 3 0.60069
CRCP CGRP receptor component 0.596402
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.595623
KIN Kin17 DNA and RNA binding protein 0.584719
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.580828
CPA3 carboxypeptidase A3 (mast cell) 0.574217
LRRC32 leucine rich repeat containing 32 0.567997
SNX9 sorting nexin 9 0.553627
GHRL ghrelin/obestatin prepropeptide 0.548971
ATF3 activating transcription factor 3 0.547032
KCNK18 potassium channel, two pore domain subfamily K, member 18 0.546644
RND1 Rho family GTPase 1 0.541992
TNF tumor necrosis factor 0.540442
GCH1 GTP cyclohydrolase 1 0.526904
CPA4 carboxypeptidase A4 0.519961
ASIC3 acid sensing (proton gated) ion channel 3 0.51919
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.512264
C11ORF40 chromosome 11 open reading frame 40 0.511112
TSPO translocator protein (18kDa) 0.503058
PTDSS1 phosphatidylserine synthase 1 0.502292
NTF3 neurotrophin 3 0.486646
IFT122 intraflagellar transport 122 0.476772
BHLHE22 basic helix-loop-helix family, member e22 0.469197
CCL2 chemokine (C-C motif) ligand 2 0.463527
PEPD peptidase D 0.462772
XCL1 chemokine (C motif) ligand 1 0.460883
IL1B interleukin 1, beta 0.456355
OPRM1 opioid receptor, mu 1 0.454847
TXN thioredoxin 0.452585
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.444676
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.440162
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.423265
WRNIP1 Werner helicase interacting protein 1 0.421765
POMC proopiomelanocortin 0.421765
SP9 Sp9 transcription factor 0.419142
LIN9 lin-9 DREAM MuvB core complex component 0.414276
GHSR growth hormone secretagogue receptor 0.413153
CALCA calcitonin-related polypeptide alpha 0.406798
KDM6B lysine (K)-specific demethylase 6B 0.403438
ASMT acetylserotonin O-methyltransferase 0.399334
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.397471
SP6 Sp6 transcription factor 0.397471
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.396353
MT1A metallothionein 1A 0.391141
UCN3 urocortin 3 0.390769
CRP C-reactive protein, pentraxin-related 0.387051
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.386308
CXCL8 chemokine (C-X-C motif) ligand 8 0.382966
IL6 interleukin 6 0.378514
PENK proenkephalin 0.377773
CD4 CD4 molecule 0.371847
THAP1 THAP domain containing, apoptosis associated protein 1 0.365932
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.362239
PPT2 palmitoyl-protein thioesterase 2 0.36187
PDYN prodynorphin 0.359289
CAMP cathelicidin antimicrobial peptide 0.353027
CRBN cereblon 0.352659
CCL3 chemokine (C-C motif) ligand 3 0.352291
PER3 period circadian clock 3 0.337242
AANAT aralkylamine N-acetyltransferase 0.332852
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.323365
GPANK1 G patch domain and ankyrin repeats 1 0.322637
ADRA1A adrenoceptor alpha 1A 0.32009
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.319363
SCO2 SCO2 cytochrome c oxidase assembly protein 0.318999
ANXA6 annexin A6 0.318272
TES testin LIM domain protein 0.313189
MEFV Mediterranean fever 0.311739
SHF Src homology 2 domain containing F 0.311739
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.308842
GALE UDP-galactose-4-epimerase 0.307757
MED28 mediator complex subunit 28 0.296211
COX5A cytochrome c oxidase subunit Va 0.294772
THEM5 thioesterase superfamily member 5 0.290821
IL10 interleukin 10 0.282225
SCN1A sodium channel, voltage gated, type I alpha subunit 0.281868
GFAP glial fibrillary acidic protein 0.281868
TPH1 tryptophan hydroxylase 1 0.273664
GRM5 glutamate receptor, metabotropic 5 0.272953
SCN1B sodium channel, voltage gated, type I beta subunit 0.270819
SUFU suppressor of fused homolog (Drosophila) 0.267267
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.266203
RBMS1 RNA binding motif, single stranded interacting protein 1 0.252774
PLK2 polo-like kinase 2 0.240497
OPRL1 opiate receptor-like 1 0.236312
CD3D CD3d molecule, delta (CD3-TCR complex) 0.230409
TACR2 tachykinin receptor 2 0.229024
CCL1 chemokine (C-C motif) ligand 1 0.228679
COMT catechol-O-methyltransferase 0.222479
HBEGF heparin-binding EGF-like growth factor 0.221793
FANCI Fanconi anemia, complementation group I 0.21974
UPK3A uroplakin 3A 0.217693
CCK cholecystokinin 0.217352
BMP2K BMP2 inducible kinase 0.216672
ADRA2A adrenoceptor alpha 2A 0.212945
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.211261
CRHR2 corticotropin releasing hormone receptor 2 0.206913
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.205916
TMPRSS15 transmembrane protease, serine 15 0.203604
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.20229
ZNF77 zinc finger protein 77 0.199681
ACSL1 acyl-CoA synthetase long-chain family member 1 0.198709
MRPL49 mitochondrial ribosomal protein L49 0.1936
CALCRL calcitonin receptor-like 0.189551
CMA1 chymase 1, mast cell 0.185313
SNAP23 synaptosomal-associated protein, 23kDa 0.185313
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.185313
DLL1 delta-like 1 (Drosophila) 0.185016
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.181222
KNG1 kininogen 1 0.180652
STAB2 stabilin 2 0.178682
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.174881
ALPPL2 alkaline phosphatase, placental-like 2 0.173057
ALPP alkaline phosphatase, placental 0.172799
ALPL alkaline phosphatase, liver/bone/kidney 0.172291
BCHE butyrylcholinesterase 0.171785
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.171036
CDK5 cyclin-dependent kinase 5 0.170054
SIK1 salt-inducible kinase 1 0.167452
LHCGR luteinizing hormone/choriogonadotropin receptor 0.165655
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.162109
PYGB phosphorylase, glycogen; brain 0.160948
PYGL phosphorylase, glycogen, liver 0.159302
TJP1 tight junction protein 1 0.157765