oxymetazoline-6350 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the oxymetazoline-6350 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ALOXE3 arachidonate lipoxygenase 3
ANGPT2 angiopoietin 2
ANGPTL2 angiopoietin-like 2
ARHGAP1 Rho GTPase activating protein 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARL14 ADP-ribosylation factor-like 14
ARMC8 armadillo repeat containing 8
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD6 CD6 molecule
CDC25A cell division cycle 25A
CISH cytokine inducible SH2-containing protein
CLCN3 chloride channel, voltage-sensitive 3
CREM cAMP responsive element modulator
CSF1R colony stimulating factor 1 receptor
CSNK1E casein kinase 1, epsilon
CTNS cystinosin, lysosomal cystine transporter
CYTH3 cytohesin 3
DOCK5 dedicator of cytokinesis 5
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
FNTB farnesyltransferase, CAAX box, beta
FURIN furin (paired basic amino acid cleaving enzyme)
GRAMD1C GRAM domain containing 1C
GSK3A glycogen synthase kinase 3 alpha
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOOK1 hook microtubule-tethering protein 1
HOXC10 homeobox C10
HPS1 Hermansky-Pudlak syndrome 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL11 interleukin 11
IL2 interleukin 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KRT86 keratin 86, type II
LAT2 linker for activation of T cells family, member 2
LIMK1 LIM domain kinase 1
LOC257152 uncharacterized LOC257152
LRRC75B leucine rich repeat containing 75B
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBD2 methyl-CpG binding domain protein 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MOCS1 molybdenum cofactor synthesis 1
MR1 major histocompatibility complex, class I-related
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYOF myoferlin
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NF2 neurofibromin 2 (merlin)
NPR2 natriuretic peptide receptor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCDH1 protocadherin 1
PCM1 pericentriolar material 1
PEX11A peroxisomal biogenesis factor 11 alpha
PGLYRP4 peptidoglycan recognition protein 4
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PWAR5 Prader Willi/Angelman region RNA 5
RAB36 RAB36, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
REEP1 receptor accessory protein 1
RIN1 Ras and Rab interactor 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPLP2 ribosomal protein, large, P2
RPS14 ribosomal protein S14
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMAD7 SMAD family member 7
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STX16 syntaxin 16
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D22A TBC1 domain family, member 22A
THOC5 THO complex 5
TLR2 toll-like receptor 2
TMEM206 transmembrane protein 206
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRADD TNFRSF1A-associated via death domain
TRIM22 tripartite motif containing 22
TTC38 tetratricopeptide repeat domain 38
TUBGCP2 tubulin, gamma complex associated protein 2
VGLL3 vestigial-like family member 3
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WIZ widely interspaced zinc finger motifs
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF224 zinc finger protein 224
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARL15 ADP-ribosylation factor-like 15
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP13A2 ATPase type 13A2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCL9 B-cell CLL/lymphoma 9
BOLA1 bolA family member 1
BTF3P12 basic transcription factor 3 pseudogene 12
CEP112 centrosomal protein 112kDa
CEP85 centrosomal protein 85kDa
CHML choroideremia-like (Rab escort protein 2)
CLK1 CDC-like kinase 1
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CTSF cathepsin F
CTSO cathepsin O
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DOCK1 dedicator of cytokinesis 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERF Ets2 repressor factor
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETNK2 ethanolamine kinase 2
EVL Enah/Vasp-like
FAM50B family with sequence similarity 50, member B
FAM86C1 family with sequence similarity 86, member C1
FUZ fuzzy planar cell polarity protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAREM GRB2 associated, regulator of MAPK1
GCA grancalcin, EF-hand calcium binding protein
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GYS1 glycogen synthase 1 (muscle)
HCFC2 host cell factor C2
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HOXA6 homeobox A6
IL13RA2 interleukin 13 receptor, alpha 2
IRF9 interferon regulatory factor 9
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KIAA0753 KIAA0753
KIF13B kinesin family member 13B
KRT75 keratin 75, type II
LCN2 lipocalin 2
LONRF3 LON peptidase N-terminal domain and ring finger 3
LSR lipolysis stimulated lipoprotein receptor
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED15 mediator complex subunit 15
METTL2B methyltransferase like 2B
MICALL2 MICAL-like 2
MISP mitotic spindle positioning
MUC7 mucin 7, secreted
NT5DC3 5'-nucleotidase domain containing 3
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OTUD3 OTU deubiquitinase 3
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE12 phosphodiesterase 12
PLAC1 placenta-specific 1
POMT2 protein-O-mannosyltransferase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRPH peripherin
PRR3 proline rich 3
RFX7 regulatory factor X, 7
S100A3 S100 calcium binding protein A3
SECISBP2 SECIS binding protein 2
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC35F6 solute carrier family 35, member F6
SLC46A3 solute carrier family 46, member 3
SLMO1 slowmo homolog 1 (Drosophila)
SPAG4 sperm associated antigen 4
SSBP3 single stranded DNA binding protein 3
STX17 syntaxin 17
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM51 transmembrane protein 51
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TSKU tsukushi, small leucine rich proteoglycan
TSPAN15 tetraspanin 15
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
TXNL4B thioredoxin-like 4B
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFP69B ZFP69 zinc finger protein B
ZMAT5 zinc finger, matrin-type 5
ZNF747 zinc finger protein 747
ZXDC ZXD family zinc finger C