oxymetazoline-2114 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the oxymetazoline-2114 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRB2 adhesion G protein-coupled receptor B2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APC adenomatous polyposis coli
APLP2 amyloid beta (A4) precursor-like protein 2
AQR aquarius intron-binding spliceosomal factor
BAX BCL2-associated X protein
BMP1 bone morphogenetic protein 1
BTG2 BTG family, member 2
C11ORF30 chromosome 11 open reading frame 30
C17ORF80 chromosome 17 open reading frame 80
CACTIN cactin, spliceosome C complex subunit
CD58 CD58 molecule
CDK6 cyclin-dependent kinase 6
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLIC2 chloride intracellular channel 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CROCC ciliary rootlet coiled-coil, rootletin
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCTN2 dynactin 2 (p50)
DNAAF1 dynein, axonemal, assembly factor 1
DUSP2 dual specificity phosphatase 2
EML2 echinoderm microtubule associated protein like 2
EPHB4 EPH receptor B4
EYA4 EYA transcriptional coactivator and phosphatase 4
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM212B family with sequence similarity 212, member B
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNDC4 fibronectin type III domain containing 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GOLGA2 golgin A2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIP2 glutamate receptor interacting protein 2
HIRA histone cell cycle regulator
HIST1H2AM histone cluster 1, H2am
HIST1H3G histone cluster 1, H3g
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOOK1 hook microtubule-tethering protein 1
IGFBP5 insulin-like growth factor binding protein 5
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIF5C kinesin family member 5C
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LRRK1 leucine-rich repeat kinase 1
LYPD3 LY6/PLAUR domain containing 3
METTL5 methyltransferase like 5
MFGE8 milk fat globule-EGF factor 8 protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MT1M metallothionein 1M
MTSS1L metastasis suppressor 1-like
NCKAP1 NCK-associated protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAX8 paired box 8
PDAP1 PDGFA associated protein 1
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB27B RAB27B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
REST RE1-silencing transcription factor
RGS4 regulator of G-protein signaling 4
RNF43 ring finger protein 43
RPL13P5 ribosomal protein L13 pseudogene 5
RWDD2A RWD domain containing 2A
SAP30 Sin3A-associated protein, 30kDa
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SENP5 SUMO1/sentrin specific peptidase 5
SERGEF secretion regulating guanine nucleotide exchange factor
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SMAD5 SMAD family member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRCAP Snf2-related CREBBP activator protein
SRRM2 serine/arginine repetitive matrix 2
TBX2 T-box 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM2D1 TM2 domain containing 1
TMEM212 transmembrane protein 212
TMEM259 transmembrane protein 259
TRIM14 tripartite motif containing 14
TRIM62 tripartite motif containing 62
TRIP11 thyroid hormone receptor interactor 11
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USB1 U6 snRNA biogenesis 1
WDR91 WD repeat domain 91
ZNF41 zinc finger protein 41
ZNF510 zinc finger protein 510
ZNF669 zinc finger protein 669
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACKR3 atypical chemokine receptor 3
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARL14 ADP-ribosylation factor-like 14
ARMC6 armadillo repeat containing 6
ARRB2 arrestin, beta 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BTBD2 BTB (POZ) domain containing 2
C11ORF71 chromosome 11 open reading frame 71
CABIN1 calcineurin binding protein 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMTA2 calmodulin binding transcription activator 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCL20 chemokine (C-C motif) ligand 20
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDT1 chromatin licensing and DNA replication factor 1
CFAP44 cilia and flagella associated protein 44
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHMP6 charged multivesicular body protein 6
CLDN15 claudin 15
CRYBA2 crystallin, beta A2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DPY19L2P2 DPY19L2 pseudogene 2
ECM1 extracellular matrix protein 1
EVPL envoplakin
FAM155A family with sequence similarity 155, member A
FANCC Fanconi anemia, complementation group C
FKBP10 FK506 binding protein 10, 65 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GID4 GID complex subunit 4
GNPDA1 glucosamine-6-phosphate deaminase 1
GTPBP2 GTP binding protein 2
HIST1H2AE histone cluster 1, H2ae
HOXC5 homeobox C5
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMPACT impact RWD domain protein
IRAK4 interleukin-1 receptor-associated kinase 4
IREB2 iron-responsive element binding protein 2
KLC2 kinesin light chain 2
KRT16 keratin 16, type I
L2HGDH L-2-hydroxyglutarate dehydrogenase
LRRC61 leucine rich repeat containing 61
MAPK12 mitogen-activated protein kinase 12
MAST3 microtubule associated serine/threonine kinase 3
MRPL52 mitochondrial ribosomal protein L52
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYLK myosin light chain kinase
MYO1E myosin IE
NABP2 nucleic acid binding protein 2
NBEAL2 neurobeachin-like 2
NPFFR1 neuropeptide FF receptor 1
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
ORC1 origin recognition complex, subunit 1
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PC pyruvate carboxylase
PEX26 peroxisomal biogenesis factor 26
PHGDH phosphoglycerate dehydrogenase
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PRMT7 protein arginine methyltransferase 7
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNMTL1 RNA methyltransferase like 1
SALL2 spalt-like transcription factor 2
SAMD9 sterile alpha motif domain containing 9
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPEG SPEG complex locus
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TEX40 testis expressed 40
TGFBR3 transforming growth factor, beta receptor III
TLN1 talin 1
TMEM104 transmembrane protein 104
TRIM21 tripartite motif containing 21
TRIM45 tripartite motif containing 45
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBB2B tubulin, beta 2B class IIb
TWISTNB TWIST neighbor
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZMAT5 zinc finger, matrin-type 5
ZNF606 zinc finger protein 606
ZNF787 zinc finger protein 787
ZNF8 zinc finger protein 8
ZNHIT2 zinc finger, HIT-type containing 2