oxybuprocaine-4115 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the oxybuprocaine-4115 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAM12 ADAM metallopeptidase domain 12
ADAP2 ArfGAP with dual PH domains 2
ADRA1A adrenoceptor alpha 1A
AKR1D1 aldo-keto reductase family 1, member D1
ALCAM activated leukocyte cell adhesion molecule
ALK anaplastic lymphoma receptor tyrosine kinase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASPH aspartate beta-hydroxylase
ATN1 atrophin 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
C19ORF66 chromosome 19 open reading frame 66
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC87 coiled-coil domain containing 87
CD22 CD22 molecule
CDC5L cell division cycle 5-like
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLCN4 chloride channel, voltage-sensitive 4
CLTA clathrin, light chain A
CNOT3 CCR4-NOT transcription complex, subunit 3
CNTLN centlein, centrosomal protein
CPN2 carboxypeptidase N, polypeptide 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTSF cathepsin F
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DOCK10 dedicator of cytokinesis 10
ELF4 E74-like factor 4 (ets domain transcription factor)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF18 fibroblast growth factor 18
FGFBP1 fibroblast growth factor binding protein 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GEMIN7 gem (nuclear organelle) associated protein 7
GFI1 growth factor independent 1 transcription repressor
GP2 glycoprotein 2 (zymogen granule membrane)
GPR85 G protein-coupled receptor 85
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIST1H4E histone cluster 1, H4e
HOXC4 homeobox C4
ICA1 islet cell autoantigen 1, 69kDa
IL2RB interleukin 2 receptor, beta
JAM3 junctional adhesion molecule 3
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KIAA1109 KIAA1109
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LAMC2 laminin, gamma 2
LDB3 LIM domain binding 3
LIMK1 LIM domain kinase 1
LOC729164 hCG1732469
MAGEA6 melanoma antigen family A6
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MOB3B MOB kinase activator 3B
MPP1 membrane protein, palmitoylated 1, 55kDa
MX1 MX dynamin-like GTPase 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NOL10 nucleolar protein 10
NPC1 Niemann-Pick disease, type C1
OMG oligodendrocyte myelin glycoprotein
OXCT2 3-oxoacid CoA transferase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDPN podoplanin
PEG3 paternally expressed 3
PHF7 PHD finger protein 7
PLEK pleckstrin
PLSCR3 phospholipid scramblase 3
PON3 paraoxonase 3
POU3F2 POU class 3 homeobox 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKCB protein kinase C, beta
PRKG2 protein kinase, cGMP-dependent, type II
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REPS1 RALBP1 associated Eps domain containing 1
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND1 Rho family GTPase 1
RUNX1 runt-related transcription factor 1
RYR1 ryanodine receptor 1 (skeletal)
SHOX2 short stature homeobox 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SIX3 SIX homeobox 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC35E2 solute carrier family 35, member E2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
STATH statherin
SZT2 seizure threshold 2 homolog (mouse)
TRD T cell receptor delta locus
TTC39A tetratricopeptide repeat domain 39A
ULBP1 UL16 binding protein 1
WDR62 WD repeat domain 62
WSB1 WD repeat and SOCS box containing 1
ZBED4 zinc finger, BED-type containing 4
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARRB2 arrestin, beta 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C21ORF91 chromosome 21 open reading frame 91
C2ORF54 chromosome 2 open reading frame 54
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX8 chromobox homolog 8
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CES3 carboxylesterase 3
CHST10 carbohydrate sulfotransferase 10
CLCF1 cardiotrophin-like cytokine factor 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF17 DDB1 and CUL4 associated factor 17
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP6 elongator acetyltransferase complex subunit 6
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
ERO1L ERO1-like (S. cerevisiae)
FAM118A family with sequence similarity 118, member A
FILIP1L filamin A interacting protein 1-like
GAMT guanidinoacetate N-methyltransferase
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR157 G protein-coupled receptor 157
GTF2I general transcription factor IIi
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HIST1H1E histone cluster 1, H1e
HIST1H2AM histone cluster 1, H2am
HMOX1 heme oxygenase 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
INO80D INO80 complex subunit D
INPP5J inositol polyphosphate-5-phosphatase J
IPO8 importin 8
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA0894 KIAA0894 protein
LPPR1 lipid phosphate phosphatase-related protein type 1
LTBP2 latent transforming growth factor beta binding protein 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NAT6 N-acetyltransferase 6 (GCN5-related)
NECAP2 NECAP endocytosis associated 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARD6B par-6 family cell polarity regulator beta
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POMT2 protein-O-mannosyltransferase 2
PROL1 proline rich, lacrimal 1
PRR14L proline rich 14-like
RAB30 RAB30, member RAS oncogene family
RAI2 retinoic acid induced 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFX7 regulatory factor X, 7
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPL10L ribosomal protein L10-like
S100A9 S100 calcium binding protein A9
SAMD9 sterile alpha motif domain containing 9
SAV1 salvador family WW domain containing protein 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNORA21 small nucleolar RNA, H/ACA box 21
SP1 Sp1 transcription factor
SSBP3 single stranded DNA binding protein 3
STAB2 stabilin 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYTL2 synaptotagmin-like 2
TEP1 telomerase-associated protein 1
TET3 tet methylcytosine dioxygenase 3
TNS2 tensin 2
TRIM16 tripartite motif containing 16
TTC17 tetratricopeptide repeat domain 17
ULBP2 UL16 binding protein 2
UPK3B uroplakin 3B
VWA1 von Willebrand factor A domain containing 1
WDR76 WD repeat domain 76
XYLT2 xylosyltransferase II
YEATS4 YEATS domain containing 4
ZBTB6 zinc finger and BTB domain containing 6
ZIC1 Zic family member 1
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675