oxybuprocaine-3996 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the oxybuprocaine-3996 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADRB1 adrenoceptor beta 1
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKAP5 A kinase (PRKA) anchor protein 5
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMP7 bone morphogenetic protein 7
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CCDC186 coiled-coil domain containing 186
CD200 CD200 molecule
CD4 CD4 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFP complement factor properdin
CLCA2 chloride channel accessory 2
CLEC4M C-type lectin domain family 4, member M
CNTNAP2 contactin associated protein-like 2
CSF1R colony stimulating factor 1 receptor
DCT dopachrome tautomerase
DDO D-aspartate oxidase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNALI1 dynein, axonemal, light intermediate chain 1
DST dystonin
EBF2 early B-cell factor 2
FAM212B family with sequence similarity 212, member B
FRK fyn-related Src family tyrosine kinase
FRMD4B FERM domain containing 4B
FRMD8 FERM domain containing 8
FYB FYN binding protein
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GYPB glycophorin B (MNS blood group)
H2AFX H2A histone family, member X
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHLA1 HERV-H LTR-associating 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IFT27 intraflagellar transport 27
IRX5 iroquois homeobox 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA0125 KIAA0125
KLHL35 kelch-like family member 35
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
LEFTY2 left-right determination factor 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRRC75B leucine rich repeat containing 75B
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEP1B meprin A, beta
MIA2 melanoma inhibitory activity 2
MORC1 MORC family CW-type zinc finger 1
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
MYH11 myosin, heavy chain 11, smooth muscle
NOTCH3 notch 3
NPFFR1 neuropeptide FF receptor 1
OAZ3 ornithine decarboxylase antizyme 3
PALM paralemmin
PAOX polyamine oxidase (exo-N4-amino)
PCDH1 protocadherin 1
PEX5L peroxisomal biogenesis factor 5-like
PHC3 polyhomeotic homolog 3 (Drosophila)
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF1 PHD finger protein 1
PHF2 PHD finger protein 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLVAP plasmalemma vesicle associated protein
PMFBP1 polyamine modulated factor 1 binding protein 1
PNPLA3 patatin-like phospholipase domain containing 3
POU6F1 POU class 6 homeobox 1
PRB1 proline-rich protein BstNI subfamily 1
PRDM14 PR domain containing 14
PRDM2 PR domain containing 2, with ZNF domain
PSD4 pleckstrin and Sec7 domain containing 4
PSG9 pregnancy specific beta-1-glycoprotein 9
RASAL2 RAS protein activator like 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RFXAP regulatory factor X-associated protein
RNASEH2B ribonuclease H2, subunit B
RPL10 ribosomal protein L10
SAA4 serum amyloid A4, constitutive
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SIGLEC6 sialic acid binding Ig-like lectin 6
SIX3 SIX homeobox 3
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STAT4 signal transducer and activator of transcription 4
SYCE1L synaptonemal complex central element protein 1-like
TMEM246 transmembrane protein 246
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPP1 tripeptidyl peptidase I
TRAPPC9 trafficking protein particle complex 9
TRIM31 tripartite motif containing 31
TRIM48 tripartite motif containing 48
TRO trophinin
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
TTLL5 tubulin tyrosine ligase-like family member 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF280B zinc finger protein 280B
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AGMAT agmatine ureohydrolase (agmatinase)
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANXA10 annexin A10
ARL15 ADP-ribosylation factor-like 15
ATAD3A ATPase family, AAA domain containing 3A
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BFSP1 beaded filament structural protein 1, filensin
BMP15 bone morphogenetic protein 15
C16ORF59 chromosome 16 open reading frame 59
CADPS2 Ca++-dependent secretion activator 2
CASZ1 castor zinc finger 1
CCS copper chaperone for superoxide dismutase
CHKB choline kinase beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIDEB cell death-inducing DFFA-like effector b
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CLEC2B C-type lectin domain family 2, member B
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CRYBB2P1 crystallin, beta B2 pseudogene 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DUSP8 dual specificity phosphatase 8
EN2 engrailed homeobox 2
ENO2 enolase 2 (gamma, neuronal)
ENOX1 ecto-NOX disulfide-thiol exchanger 1
FAT4 FAT atypical cadherin 4
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FGGY FGGY carbohydrate kinase domain containing
GAREM GRB2 associated, regulator of MAPK1
GMEB1 glucocorticoid modulatory element binding protein 1
GPC3 glypican 3
GPX2 glutathione peroxidase 2
H2AFJ H2A histone family, member J
HDAC7 histone deacetylase 7
HIST1H2AJ histone cluster 1, H2aj
HOXA1 homeobox A1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
LMCD1 LIM and cysteine-rich domains 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPAR4 lysophosphatidic acid receptor 4
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRK1 leucine-rich repeat kinase 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFSD10 major facilitator superfamily domain containing 10
MFSD11 major facilitator superfamily domain containing 11
MOCS3 molybdenum cofactor synthesis 3
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NHEJ1 nonhomologous end-joining factor 1
NPM3 nucleophosmin/nucleoplasmin 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSR2 odd-skipped related transciption factor 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARD6A par-6 family cell polarity regulator alpha
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRR7 proline rich 7 (synaptic)
PRSS53 protease, serine, 53
RAD50 RAD50 homolog (S. cerevisiae)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RIN1 Ras and Rab interactor 1
RPL23AP32 ribosomal protein L23a pseudogene 32
S100A3 S100 calcium binding protein A3
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SPEG SPEG complex locus
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST5 suppression of tumorigenicity 5
STARD13 StAR-related lipid transfer (START) domain containing 13
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM53 transmembrane protein 53
TNNI3 troponin I type 3 (cardiac)
TRAPPC6A trafficking protein particle complex 6A
TTLL1 tubulin tyrosine ligase-like family member 1
TXLNG taxilin gamma
UGT8 UDP glycosyltransferase 8
VGLL3 vestigial-like family member 3
WDR33 WD repeat domain 33
ZBTB48 zinc finger and BTB domain containing 48
ZNF227 zinc finger protein 227
ZNF276 zinc finger protein 276
ZNF286A zinc finger protein 286A
ZNF34 zinc finger protein 34
ZNF358 zinc finger protein 358
ZNF606 zinc finger protein 606
ZNF702P zinc finger protein 702, pseudogene
ZNF767P zinc finger family member 767, pseudogene