oxolinic acid-5519 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the oxolinic acid-5519 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
AAGAB alpha- and gamma-adaptin binding protein
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACPP acid phosphatase, prostate
ADGRA2 adhesion G protein-coupled receptor A2
AKAP7 A kinase (PRKA) anchor protein 7
ANGEL2 angel homolog 2 (Drosophila)
APOE apolipoprotein E
ARG1 arginase 1
ASB1 ankyrin repeat and SOCS box containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTG3 BTG family, member 3
C2ORF72 chromosome 2 open reading frame 72
CALML3 calmodulin-like 3
CCRL2 chemokine (C-C motif) receptor-like 2
CD101 CD101 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CNTN1 contactin 1
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CST4 cystatin S
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DSCAM Down syndrome cell adhesion molecule
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
ESR1 estrogen receptor 1
EXTL3 exostosin-like glycosyltransferase 3
FAM76A family with sequence similarity 76, member A
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLRA2 glycine receptor, alpha 2
GPM6B glycoprotein M6B
HABP4 hyaluronan binding protein 4
HIST1H1E histone cluster 1, H1e
IBSP integrin-binding sialoprotein
ICOSLG inducible T-cell co-stimulator ligand
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL22 interleukin 22
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LARP7 La ribonucleoprotein domain family, member 7
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAGEC3 melanoma antigen family C3
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MIR622 microRNA 622
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUCB1 nucleobindin 1
OSBPL10 oxysterol binding protein-like 10
OSMR oncostatin M receptor
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
POFUT1 protein O-fucosyltransferase 1
PRKCH protein kinase C, eta
PRLH prolactin releasing hormone
PRSS50 protease, serine, 50
PSEN2 presenilin 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RUNX1 runt-related transcription factor 1
SCAI suppressor of cancer cell invasion
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2D2A SH2 domain containing 2A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A8 solute carrier family 12, member 8
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMAD4 SMAD family member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STX1A syntaxin 1A (brain)
STXBP5L syntaxin binding protein 5-like
SUN1 Sad1 and UNC84 domain containing 1
TAPBP TAP binding protein (tapasin)
TBX5 T-box 5
TET3 tet methylcytosine dioxygenase 3
TK2 thymidine kinase 2, mitochondrial
TMEM63A transmembrane protein 63A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPK1 thiamin pyrophosphokinase 1
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
UBE2L3 ubiquitin-conjugating enzyme E2L 3
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UTRN utrophin
VAMP5 vesicle-associated membrane protein 5
ZYX zyxin

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AXIN1 axin 1
BBC3 BCL2 binding component 3
BBS1 Bardet-Biedl syndrome 1
BIRC7 baculoviral IAP repeat containing 7
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF95 chromosome 11 open reading frame 95
C16ORF62 chromosome 16 open reading frame 62
C5ORF45 chromosome 5 open reading frame 45
CAPN1 calpain 1, (mu/I) large subunit
CBX4 chromobox homolog 4
CCDC186 coiled-coil domain containing 186
CCNE1 cyclin E1
CCNL2 cyclin L2
CDC45 cell division cycle 45
CEP170B centrosomal protein 170B
CES3 carboxylesterase 3
CISH cytokine inducible SH2-containing protein
CIT citron rho-interacting serine/threonine kinase
CLDN4 claudin 4
CLEC4E C-type lectin domain family 4, member E
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CTSK cathepsin K
DET1 de-etiolated homolog 1 (Arabidopsis)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELSPBP1 epididymal sperm binding protein 1
EYA2 EYA transcriptional coactivator and phosphatase 2
F2R coagulation factor II (thrombin) receptor
FAM63A family with sequence similarity 63, member A
FGGY FGGY carbohydrate kinase domain containing
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2AI histone cluster 1, H2ai
HIST2H2AA3 histone cluster 2, H2aa3
IDI2-AS1 IDI2 antisense RNA 1
IMPACT impact RWD domain protein
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA10 integrin, alpha 10
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLK6 kallikrein-related peptidase 6
KREMEN2 kringle containing transmembrane protein 2
KRT8P12 keratin 8 pseudogene 12
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LOC730101 uncharacterized LOC730101
LRP3 low density lipoprotein receptor-related protein 3
MAMLD1 mastermind-like domain containing 1
METTL4 methyltransferase like 4
MFSD11 major facilitator superfamily domain containing 11
MON1B MON1 secretory trafficking family member B
MYL5 myosin, light chain 5, regulatory
NPIPB15 nuclear pore complex interacting protein family, member B15
ONECUT2 one cut homeobox 2
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRSS8 protease, serine, 8
PUF60 poly-U binding splicing factor 60KDa
PVRL3 poliovirus receptor-related 3
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RECQL4 RecQ protein-like 4
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIBC2 RIB43A domain with coiled-coils 2
RNF25 ring finger protein 25
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SMIM14 small integral membrane protein 14
SNORA21 small nucleolar RNA, H/ACA box 21
SOX13 SRY (sex determining region Y)-box 13
SPIDR scaffolding protein involved in DNA repair
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCTA T-cell leukemia translocation altered
TMEM39B transmembrane protein 39B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN1 tetraspanin 1
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
WRAP73 WD repeat containing, antisense to TP73
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF211 zinc finger protein 211
ZSCAN31 zinc finger and SCAN domain containing 31