oxolinic acid-2266 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the oxolinic acid-2266 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
AGER advanced glycosylation end product-specific receptor
ARHGAP28 Rho GTPase activating protein 28
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMT acetylserotonin O-methyltransferase
ATF7 activating transcription factor 7
ATN1 atrophin 1
B3GAT1 beta-1,3-glucuronyltransferase 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP10 bone morphogenetic protein 10
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALCR calcitonin receptor
CCL19 chemokine (C-C motif) ligand 19
CCNK cyclin K
CD101 CD101 molecule
CD300A CD300a molecule
CD58 CD58 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CNTLN centlein, centrosomal protein
CPQ carboxypeptidase Q
CRMP1 collapsin response mediator protein 1
CSF1 colony stimulating factor 1 (macrophage)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSZ cathepsin Z
CYLD cylindromatosis (turban tumor syndrome)
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DLC1 DLC1 Rho GTPase activating protein
DMBT1 deleted in malignant brain tumors 1
DNAI2 dynein, axonemal, intermediate chain 2
DTX3 deltex 3, E3 ubiquitin ligase
EIF3F eukaryotic translation initiation factor 3, subunit F
ETV5 ets variant 5
ETV7 ets variant 7
EXOSC1 exosome component 1
FAM46C family with sequence similarity 46, member C
FBXO40 F-box protein 40
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGFR1 fibroblast growth factor receptor 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAS7 growth arrest-specific 7
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRM8 glutamate receptor, metabotropic 8
GSK3A glycogen synthase kinase 3 alpha
HCG4 HLA complex group 4 (non-protein coding)
HFE hemochromatosis
HIST1H2BM histone cluster 1, H2bm
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HOXB3 homeobox B3
HOXC5 homeobox C5
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
INO80D INO80 complex subunit D
IRAK3 interleukin-1 receptor-associated kinase 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIF5A kinesin family member 5A
KSR1 kinase suppressor of ras 1
LAPTM5 lysosomal protein transmembrane 5
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRC6 leucine rich repeat containing 6
LRRC75B leucine rich repeat containing 75B
MAB21L1 mab-21-like 1 (C. elegans)
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MEF2D myocyte enhancer factor 2D
MEG3 maternally expressed 3 (non-protein coding)
MINK1 misshapen-like kinase 1
MLANA melan-A
MTSS1L metastasis suppressor 1-like
NRP1 neuropilin 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX2 paired box 2
PAX9 paired box 9
PBX2 pre-B-cell leukemia homeobox 2
PCBP3 poly(rC) binding protein 3
PCDHB17P protocadherin beta 17 pseudogene
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM4 PDZ and LIM domain 4
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PRKCI protein kinase C, iota
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS12 regulator of G-protein signaling 12
RIN3 Ras and Rab interactor 3
RS1 retinoschisin 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
STAT2 signal transducer and activator of transcription 2, 113kDa
STEAP4 STEAP family member 4
TCF25 transcription factor 25 (basic helix-loop-helix)
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TEX15 testis expressed 15
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TPMT thiopurine S-methyltransferase
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
ZNF175 zinc finger protein 175

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABHD17B abhydrolase domain containing 17B
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTN4 actinin, alpha 4
ADAP2 ArfGAP with dual PH domains 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA1 annexin A1
ARRB2 arrestin, beta 2
BCORL1 BCL6 corepressor-like 1
C22ORF29 chromosome 22 open reading frame 29
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
C5AR2 complement component 5a receptor 2
C6ORF47 chromosome 6 open reading frame 47
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD82 CD82 molecule
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLCF1 cardiotrophin-like cytokine factor 1
CLSTN2 calsyntenin 2
CNR2 cannabinoid receptor 2 (macrophage)
CRELD1 cysteine-rich with EGF-like domains 1
DGAT1 diacylglycerol O-acyltransferase 1
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
F2R coagulation factor II (thrombin) receptor
FAM188A family with sequence similarity 188, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FOXN2 forkhead box N2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLRA1 glycine receptor, alpha 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH2L G patch domain containing 2-like
GPR143 G protein-coupled receptor 143
GRB7 growth factor receptor-bound protein 7
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H2AI histone cluster 1, H2ai
HIST2H2AA3 histone cluster 2, H2aa3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMPACT impact RWD domain protein
INCENP inner centromere protein antigens 135/155kDa
IPO8 importin 8
KCTD7 potassium channel tetramerization domain containing 7
KLHL21 kelch-like family member 21
LIF leukemia inhibitory factor
LMNB1 lamin B1
LYPD3 LY6/PLAUR domain containing 3
MBTD1 mbt domain containing 1
METTL8 methyltransferase like 8
MSI1 musashi RNA-binding protein 1
MVD mevalonate (diphospho) decarboxylase
NBEAL2 neurobeachin-like 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKX3-2 NK3 homeobox 2
NPTX1 neuronal pentraxin I
NXPH4 neurexophilin 4
OTUD3 OTU deubiquitinase 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITX2 paired-like homeodomain 2
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRODH proline dehydrogenase (oxidase) 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RARS arginyl-tRNA synthetase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL10L ribosomal protein L10-like
SCRN3 secernin 3
SEC61G Sec61 gamma subunit
SFXN1 sideroflexin 1
SKI SKI proto-oncogene
SNTA1 syntrophin, alpha 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STIM1 stromal interaction molecule 1
SUGP1 SURP and G patch domain containing 1
TBC1D2 TBC1 domain family, member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIM21 tripartite motif containing 21
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UBOX5 U-box domain containing 5
UBQLN4 ubiquilin 4
WDR62 WD repeat domain 62
ZBED1 zinc finger, BED-type containing 1
ZNF227 zinc finger protein 227
ZNF329 zinc finger protein 329
ZNF573 zinc finger protein 573
ZNF611 zinc finger protein 611