oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. (Gene Ontology, GO_0016706)
External Link http://amigo.geneontology.org/amigo/term/GO:0016706
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Genes

48 genes performing the oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALKBH5 AlkB family member 5, RNA demethylase
ALKBH6 alkB, alkylation repair homolog 6 (E. coli)
ALKBH8 alkB, alkylation repair homolog 8 (E. coli)
ASPH aspartate beta-hydroxylase
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C14ORF169 chromosome 14 open reading frame 169
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
FTO fat mass and obesity associated
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KDM2B lysine (K)-specific demethylase 2B
KDM4A lysine (K)-specific demethylase 4A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KDM5C lysine (K)-specific demethylase 5C
KDM5D lysine (K)-specific demethylase 5D
KDM7A lysine (K)-specific demethylase 7A
KDM8 lysine (K)-specific demethylase 8
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P3H1 prolyl 3-hydroxylase 1
P3H2 prolyl 3-hydroxylase 2
P3H3 prolyl 3-hydroxylase 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III
P4HB prolyl 4-hydroxylase, beta polypeptide
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDIA2 protein disulfide isomerase family A, member 2
PDILT protein disulfide isomerase-like, testis expressed
PHF8 PHD finger protein 8
PHYH phytanoyl-CoA 2-hydroxylase
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
TET1 tet methylcytosine dioxygenase 1
TET2 tet methylcytosine dioxygenase 2
TET3 tet methylcytosine dioxygenase 3
TMLHE trimethyllysine hydroxylase, epsilon
TYW5 tRNA-yW synthesizing protein 5