oxidative stress Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma (Mammalian Phenotype Ontology, MP_0003674)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003674
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Genes

76 gene mutations causing the oxidative stress phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APOE apolipoprotein E
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
ATP7A ATPase, Cu++ transporting, alpha polypeptide
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CBS cystathionine-beta-synthase
CLP1 cleavage and polyadenylation factor I subunit 1
COQ9 coenzyme Q9
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
FBLN5 fibulin 5
FBXL5 F-box and leucine-rich repeat protein 5
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GLMP glycosylated lysosomal membrane protein
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
GPX7 glutathione peroxidase 7
GSTA4 glutathione S-transferase alpha 4
GSTZ1 glutathione S-transferase zeta 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HUS1 HUS1 checkpoint homolog (S. pombe)
JUN jun proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KIAA0101 KIAA0101
KL klotho
LDLR low density lipoprotein receptor
MSRA methionine sulfoxide reductase A
MSRB1 methionine sulfoxide reductase B1
MSTN myostatin
MTM1 myotubularin 1
NCF1 neutrophil cytosolic factor 1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOX4 NADPH oxidase 4
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX11B peroxisomal biogenesis factor 11 beta
PINK1 PTEN induced putative kinase 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN5 perilipin 5
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K
PRDX4 peroxiredoxin 4
PRDX6 peroxiredoxin 6
RALBP1 ralA binding protein 1
RCAN1 regulator of calcineurin 1
RGN regucalcin
RNF7 ring finger protein 7
SEP15 15 kDa selenoprotein
SGMS1 sphingomyelin synthase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STEAP4 STEAP family member 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TOP1MT topoisomerase (DNA) I, mitochondrial
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
USP10 ubiquitin specific peptidase 10
VASN vasorin
WRN Werner syndrome, RecQ helicase-like
XDH xanthine dehydrogenase
XPC xeroderma pigmentosum, complementation group C
ZFP36 ZFP36 ring finger protein