oxetacaine-4829 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the oxetacaine-4829 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADCK4 aarF domain containing kinase 4
ADRBK1 adrenergic, beta, receptor kinase 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ARC activity-regulated cytoskeleton-associated protein
ART1 ADP-ribosyltransferase 1
ARTN artemin
ATF5 activating transcription factor 5
BCO1 beta-carotene oxygenase 1
BTN3A1 butyrophilin, subfamily 3, member A1
C10ORF12 chromosome 10 open reading frame 12
C14ORF79 chromosome 14 open reading frame 79
C7ORF69 chromosome 7 open reading frame 69
CD72 CD72 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEMIP cell migration inducing protein, hyaluronan binding
CGA glycoprotein hormones, alpha polypeptide
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN6 chloride channel, voltage-sensitive 6
CPEB1 cytoplasmic polyadenylation element binding protein 1
DCTN1 dynactin 1
DOCK9 dedicator of cytokinesis 9
EGR3 early growth response 3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
F13B coagulation factor XIII, B polypeptide
FBLN1 fibulin 1
FHL2 four and a half LIM domains 2
FRZB frizzled-related protein
GRIP2 glutamate receptor interacting protein 2
GRK5 G protein-coupled receptor kinase 5
GSK3A glycogen synthase kinase 3 alpha
GYPB glycophorin B (MNS blood group)
HBS1L HBS1-like translational GTPase
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA7 homeobox A7
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT22 intraflagellar transport 22
IGFBP5 insulin-like growth factor binding protein 5
IRF4 interferon regulatory factor 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHDC8A kelch domain containing 8A
KRT85 keratin 85, type II
LAT2 linker for activation of T cells family, member 2
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIN7A lin-7 homolog A (C. elegans)
LOC100286895 cell division cycle 27 homolog pseudogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBD2 methyl-CpG binding domain protein 2
MCTP2 multiple C2 domains, transmembrane 2
MKRN3 makorin ring finger protein 3
MMP3 matrix metallopeptidase 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP2 neuropilin 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OVOL1 ovo-like zinc finger 1
PARD6B par-6 family cell polarity regulator beta
PARVB parvin, beta
PAX8 paired box 8
PCDHGA10 protocadherin gamma subfamily A, 10
PDE8B phosphodiesterase 8B
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGR progesterone receptor
PHC3 polyhomeotic homolog 3 (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PLCD1 phospholipase C, delta 1
PLXNC1 plexin C1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB3 proline-rich protein BstNI subfamily 3
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROL1 proline rich, lacrimal 1
PVRL3 poliovirus receptor-related 3
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
SIRPA signal-regulatory protein alpha
SIRT5 sirtuin 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SS18 synovial sarcoma translocation, chromosome 18
TBX5 T-box 5
THY1 Thy-1 cell surface antigen
TLDC1 TBC/LysM-associated domain containing 1
TMEM63A transmembrane protein 63A
TMPRSS3 transmembrane protease, serine 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TPP1 tripeptidyl peptidase I
TRDMT1 tRNA aspartic acid methyltransferase 1
TREX1 three prime repair exonuclease 1
VN1R1 vomeronasal 1 receptor 1
ZBTB14 zinc finger and BTB domain containing 14
ZBTB22 zinc finger and BTB domain containing 22

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADCY6 adenylate cyclase 6
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
AR androgen receptor
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB2 arrestin, beta 2
BACE1 beta-site APP-cleaving enzyme 1
BEX4 brain expressed, X-linked 4
C11ORF68 chromosome 11 open reading frame 68
C1ORF159 chromosome 1 open reading frame 159
C6ORF47 chromosome 6 open reading frame 47
C7ORF43 chromosome 7 open reading frame 43
CD302 CD302 molecule
CEP85 centrosomal protein 85kDa
CGREF1 cell growth regulator with EF-hand domain 1
CLSPN claspin
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND4A DENN/MADD domain containing 4A
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAL4 dynein, axonemal, light chain 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FBXL6 F-box and leucine-rich repeat protein 6
FKBPL FK506 binding protein like
GEMIN8 gem (nuclear organelle) associated protein 8
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRB7 growth factor receptor-bound protein 7
GSTM2 glutathione S-transferase mu 2 (muscle)
GYS1 glycogen synthase 1 (muscle)
HP1BP3 heterochromatin protein 1, binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFT140 intraflagellar transport 140
INPPL1 inositol polyphosphate phosphatase-like 1
KAT2A K(lysine) acetyltransferase 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KNTC1 kinetochore associated 1
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG1 ligase I, DNA, ATP-dependent
LOC257152 uncharacterized LOC257152
MANBA mannosidase, beta A, lysosomal
METTL16 methyltransferase like 16
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MPDU1 mannose-P-dolichol utilization defect 1
MYL5 myosin, light chain 5, regulatory
NRSN2 neurensin 2
NSD1 nuclear receptor binding SET domain protein 1
NT5DC3 5'-nucleotidase domain containing 3
ODF2 outer dense fiber of sperm tails 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PANK4 pantothenate kinase 4
PARP16 poly (ADP-ribose) polymerase family, member 16
PCSK7 proprotein convertase subtilisin/kexin type 7
PER3 period circadian clock 3
PFDN6 prefoldin subunit 6
PGBD5 piggyBac transposable element derived 5
PHACTR4 phosphatase and actin regulator 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PKN1 protein kinase N1
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRICKLE3 prickle homolog 3 (Drosophila)
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRODH proline dehydrogenase (oxidase) 1
PTPRU protein tyrosine phosphatase, receptor type, U
PYCRL pyrroline-5-carboxylate reductase-like
RAB5B RAB5B, member RAS oncogene family
RNH1 ribonuclease/angiogenin inhibitor 1
RPAP1 RNA polymerase II associated protein 1
RUNDC3B RUN domain containing 3B
SCPEP1 serine carboxypeptidase 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD1A SET domain containing 1A
SIX1 SIX homeobox 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SPIDR scaffolding protein involved in DNA repair
SPINK5 serine peptidase inhibitor, Kazal type 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TARP TCR gamma alternate reading frame protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBI transforming growth factor, beta-induced, 68kDa
THUMPD2 THUMP domain containing 2
TMEM180 transmembrane protein 180
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBXN6 UBX domain protein 6
VGF VGF nerve growth factor inducible
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNHIT2 zinc finger, HIT-type containing 2
ZW10 zw10 kinetochore protein