oxetacaine-4246 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the oxetacaine-4246 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C4 aldo-keto reductase family 1, member C4
AQP3 aquaporin 3 (Gill blood group)
ARHGAP22 Rho GTPase activating protein 22
ATXN8OS ATXN8 opposite strand (non-protein coding)
BLZF1 basic leucine zipper nuclear factor 1
BMP10 bone morphogenetic protein 10
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF63 chromosome 11 open reading frame 63
C1ORF54 chromosome 1 open reading frame 54
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARD14 caspase recruitment domain family, member 14
CD58 CD58 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
DCTN2 dynactin 2 (p50)
DDIT4 DNA-damage-inducible transcript 4
DGCR6L DiGeorge syndrome critical region gene 6-like
DIO2 deiodinase, iodothyronine, type II
DMP1 dentin matrix acidic phosphoprotein 1
ENO3 enolase 3 (beta, muscle)
EPS8L1 EPS8-like 1
ERN1 endoplasmic reticulum to nucleus signaling 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FGF1 fibroblast growth factor 1 (acidic)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GC group-specific component (vitamin D binding protein)
GK3P glycerol kinase 3 pseudogene
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
IZUMO4 IZUMO family member 4
KIAA1467 KIAA1467
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100287387 uncharacterized LOC100287387
LSP1 lymphocyte-specific protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK8 mitogen-activated protein kinase 8
MEFV Mediterranean fever
MFAP3L microfibrillar-associated protein 3-like
NAV3 neuron navigator 3
NDNF neuron-derived neurotrophic factor
NEK1 NIMA-related kinase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NKX3-1 NK3 homeobox 1
NOS1 nitric oxide synthase 1 (neuronal)
NPHP1 nephronophthisis 1 (juvenile)
NPR2 natriuretic peptide receptor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAZ3 ornithine decarboxylase antizyme 3
OGDHL oxoglutarate dehydrogenase-like
PCDH17 protocadherin 17
PDGFA platelet-derived growth factor alpha polypeptide
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PLA2R1 phospholipase A2 receptor 1, 180kDa
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYGO1 pygopus family PHD finger 1
RECQL5 RecQ protein-like 5
RGS5 regulator of G-protein signaling 5
RLN1 relaxin 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMO smoothened, frizzled class receptor
SOCS1 suppressor of cytokine signaling 1
SPANXC SPANX family, member C
SPON1 spondin 1, extracellular matrix protein
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STK16 serine/threonine kinase 16
SUSD5 sushi domain containing 5
SYNJ1 synaptojanin 1
THPO thrombopoietin
WNT16 wingless-type MMTV integration site family, member 16
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZFP64 ZFP64 zinc finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF507 zinc finger protein 507
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADGRB2 adhesion G protein-coupled receptor B2
AHDC1 AT hook, DNA binding motif, containing 1
AK5 adenylate kinase 5
ALOX12 arachidonate 12-lipoxygenase
ANXA2P1 annexin A2 pseudogene 1
C22ORF46 chromosome 22 open reading frame 46
CAPN15 calpain 15
CCL2 chemokine (C-C motif) ligand 2
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDT1 chromatin licensing and DNA replication factor 1
CHMP6 charged multivesicular body protein 6
CIDEB cell death-inducing DFFA-like effector b
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DSPP dentin sialophosphoprotein
EDAR ectodysplasin A receptor
FBXO2 F-box protein 2
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPR1 G protein-coupled receptor 1
GRM4 glutamate receptor, metabotropic 4
H1FX H1 histone family, member X
HIST1H4D histone cluster 1, H4d
HOXC8 homeobox C8
HPR haptoglobin-related protein
IFNA17 interferon, alpha 17
IL36RN interleukin 36 receptor antagonist
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1456 KIAA1456
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
KRT8P12 keratin 8 pseudogene 12
LIME1 Lck interacting transmembrane adaptor 1
LINC00115 long intergenic non-protein coding RNA 115
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMCD1 LIM and cysteine-rich domains 1
LOC100287590 uncharacterized LOC100287590
LOC729164 hCG1732469
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFGE8 milk fat globule-EGF factor 8 protein
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
MYL9 myosin, light chain 9, regulatory
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NOTCH4 notch 4
NPIPB3 nuclear pore complex interacting protein family, member B3
OASL 2'-5'-oligoadenylate synthetase-like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PALM paralemmin
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAYSD1 SAYSVFN motif domain containing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCAI suppressor of cancer cell invasion
SCGB2A2 secretoglobin, family 2A, member 2
SIRT6 sirtuin 6
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SP1 Sp1 transcription factor
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STEAP4 STEAP family member 4
TESPA1 thymocyte expressed, positive selection associated 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM184C transmembrane protein 184C
TOM1 target of myb1 (chicken)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
WDR4 WD repeat domain 4
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22
ZFHX3 zinc finger homeobox 3
ZNF276 zinc finger protein 276
ZNF574 zinc finger protein 574
ZNF74 zinc finger protein 74
ZYX zyxin