orphenadrine-2318 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the orphenadrine-2318 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACACB acetyl-CoA carboxylase beta
ACPP acid phosphatase, prostate
ADAM22 ADAM metallopeptidase domain 22
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AHNAK2 AHNAK nucleoprotein 2
AKAP7 A kinase (PRKA) anchor protein 7
ALPK1 alpha-kinase 1
ARMC4 armadillo repeat containing 4
ARPIN actin-related protein 2/3 complex inhibitor
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
BTN3A1 butyrophilin, subfamily 3, member A1
C17ORF59 chromosome 17 open reading frame 59
C1QB complement component 1, q subcomponent, B chain
C5ORF42 chromosome 5 open reading frame 42
C8ORF44 chromosome 8 open reading frame 44
CAV2 caveolin 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD8A CD8a molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CPB1 carboxypeptidase B1 (tissue)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR2 corticotropin releasing hormone receptor 2
DEAF1 DEAF1 transcription factor
DGAT1 diacylglycerol O-acyltransferase 1
DUSP6 dual specificity phosphatase 6
EFNB3 ephrin-B3
ELL elongation factor RNA polymerase II
ELP6 elongator acetyltransferase complex subunit 6
EN2 engrailed homeobox 2
EPOR erythropoietin receptor
ETV5 ets variant 5
FADS2 fatty acid desaturase 2
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
FOXN3 forkhead box N3
FRMD8 FERM domain containing 8
GGT1 gamma-glutamyltransferase 1
GMPR guanosine monophosphate reductase
GP1BB glycoprotein Ib (platelet), beta polypeptide
GRIP2 glutamate receptor interacting protein 2
HDAC6 histone deacetylase 6
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HHAT hedgehog acyltransferase
HIPK3 homeodomain interacting protein kinase 3
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ICOSLG inducible T-cell co-stimulator ligand
JUN jun proto-oncogene
KLHL22 kelch-like family member 22
KRT83 keratin 83, type II
MAPK8 mitogen-activated protein kinase 8
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MLXIPL MLX interacting protein-like
MMP25 matrix metallopeptidase 25
MST1R macrophage stimulating 1 receptor
NCAPH2 non-SMC condensin II complex, subunit H2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPCML opioid binding protein/cell adhesion molecule-like
PARVA parvin, alpha
PARVB parvin, beta
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPARD peroxisome proliferator-activated receptor delta
PRAMEF10 PRAME family member 10
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTHLH parathyroid hormone-like hormone
PXN paxillin
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHEB Ras homolog enriched in brain
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RUFY3 RUN and FYVE domain containing 3
SAG S-antigen; retina and pineal gland (arrestin)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2D2A SH2 domain containing 2A
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SPARCL1 SPARC-like 1 (hevin)
SRRT serrate, RNA effector molecule
TACC1 transforming, acidic coiled-coil containing protein 1
TAOK2 TAO kinase 2
TDRD12 tudor domain containing 12
TEX15 testis expressed 15
TMEM176A transmembrane protein 176A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM49 tripartite motif containing 49
TUBBP5 tubulin, beta pseudogene 5
VNN1 vanin 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF358 zinc finger protein 358
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGBL2 ATP/GTP binding protein-like 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARMC6 armadillo repeat containing 6
BFSP1 beaded filament structural protein 1, filensin
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIRC7 baculoviral IAP repeat containing 7
BMP10 bone morphogenetic protein 10
C1QTNF3 C1q and tumor necrosis factor related protein 3
CCDC85C coiled-coil domain containing 85C
CD70 CD70 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CES3 carboxylesterase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CLDND1 claudin domain containing 1
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNGB3 cyclic nucleotide gated channel beta 3
CPED1 cadherin-like and PC-esterase domain containing 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRLF1 cytokine receptor-like factor 1
CRMP1 collapsin response mediator protein 1
DEFA4 defensin, alpha 4, corticostatin
DENND5B DENN/MADD domain containing 5B
DOK2 docking protein 2, 56kDa
EDAR ectodysplasin A receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EML4 echinoderm microtubule associated protein like 4
EXD3 exonuclease 3'-5' domain containing 3
FAM169A family with sequence similarity 169, member A
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GFI1 growth factor independent 1 transcription repressor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GOLGA1 golgin A1
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA1L heat shock 70kDa protein 1-like
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM8 lysine (K)-specific demethylase 8
KEL Kell blood group, metallo-endopeptidase
LAMB3 laminin, beta 3
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRP2 low density lipoprotein receptor-related protein 2
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LTC4S leukotriene C4 synthase
NEUROD1 neuronal differentiation 1
NIPAL2 NIPA-like domain containing 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PALM paralemmin
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRLH prolactin releasing hormone
RAB33A RAB33A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RCOR3 REST corepressor 3
RNF39 ring finger protein 39
RPH3A rabphilin 3A
SCGB2A2 secretoglobin, family 2A, member 2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SETD1A SET domain containing 1A
SH2D4A SH2 domain containing 4A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SRPX sushi-repeat containing protein, X-linked
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTN2 tectonic family member 2
TICAM1 toll-like receptor adaptor molecule 1
TMEM209 transmembrane protein 209
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM25 tripartite motif containing 25
TTC30A tetratricopeptide repeat domain 30A
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
YY2 YY2 transcription factor
ZBTB48 zinc finger and BTB domain containing 48
ZNF41 zinc finger protein 41
ZNF516 zinc finger protein 516
ZNF862 zinc finger protein 862