orlistat-6388 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the orlistat-6388 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABHD2 abhydrolase domain containing 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AMPD3 adenosine monophosphate deaminase 3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ARHGAP44 Rho GTPase activating protein 44
ARID1A AT rich interactive domain 1A (SWI-like)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BRCA2 breast cancer 2, early onset
C19ORF57 chromosome 19 open reading frame 57
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC134 coiled-coil domain containing 134
CCDC9 coiled-coil domain containing 9
CLTC clathrin, heavy chain (Hc)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL14A1 collagen, type XIV, alpha 1
COPE coatomer protein complex, subunit epsilon
CORT cortistatin
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EPHA5 EPH receptor A5
EPS8L1 EPS8-like 1
ETV1 ets variant 1
FAM46C family with sequence similarity 46, member C
FAM63B family with sequence similarity 63, member B
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL2 FOS-like antigen 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GNAS GNAS complex locus
GPR1 G protein-coupled receptor 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRM8 glutamate receptor, metabotropic 8
HIRA histone cell cycle regulator
HRG histidine-rich glycoprotein
ICA1 islet cell autoantigen 1, 69kDa
IL16 interleukin 16
INSIG1 insulin induced gene 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JAG1 jagged 1
KLHL25 kelch-like family member 25
LAMA4 laminin, alpha 4
LIMK2 LIM domain kinase 2
LIN7B lin-7 homolog B (C. elegans)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGOH2P mago-nashi homolog 2, pseudogene
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP2 microtubule-associated protein 2
MAPK11 mitogen-activated protein kinase 11
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED16 mediator complex subunit 16
MEFV Mediterranean fever
MSX2 msh homeobox 2
MUC13 mucin 13, cell surface associated
MUC3A mucin 3A, cell surface associated
NEB nebulin
NEBL nebulette
NPR3 natriuretic peptide receptor 3
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR6A1 nuclear receptor subfamily 6, group A, member 1
ONECUT2 one cut homeobox 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEX5L peroxisomal biogenesis factor 5-like
PIAS4 protein inhibitor of activated STAT, 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLXNA3 plexin A3
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PPARD peroxisome proliferator-activated receptor delta
RBM17 RNA binding motif protein 17
REEP2 receptor accessory protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFPL1S RFPL1 antisense RNA 1
RFPL3 ret finger protein-like 3
RNF126P1 ring finger protein 126 pseudogene 1
SCAND2P SCAN domain containing 2 pseudogene
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFTPB surfactant protein B
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG7 SMG7 nonsense mediated mRNA decay factor
SSTR4 somatostatin receptor 4
SUGP1 SURP and G patch domain containing 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBXA2R thromboxane A2 receptor
THRAP3 thyroid hormone receptor associated protein 3
TSPAN2 tetraspanin 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WAS Wiskott-Aldrich syndrome
WFDC2 WAP four-disulfide core domain 2
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF154 zinc finger protein 154
ZNF224 zinc finger protein 224
ZNF280A zinc finger protein 280A

decreased expression

Symbol Name
ACOXL acyl-CoA oxidase-like
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALPK1 alpha-kinase 1
ALPK3 alpha-kinase 3
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ASB7 ankyrin repeat and SOCS box containing 7
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BEX4 brain expressed, X-linked 4
C16ORF45 chromosome 16 open reading frame 45
C17ORF80 chromosome 17 open reading frame 80
CA5B carbonic anhydrase VB, mitochondrial
CBX8 chromobox homolog 8
CCDC71 coiled-coil domain containing 71
CDK20 cyclin-dependent kinase 20
CFAP69 cilia and flagella associated protein 69
CHM choroideremia (Rab escort protein 1)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CIDEB cell death-inducing DFFA-like effector b
CLSTN3 calsyntenin 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRMP1 collapsin response mediator protein 1
CYTH3 cytohesin 3
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGLN3 egl-9 family hypoxia-inducible factor 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FGF6 fibroblast growth factor 6
FLJ22184
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GGTLC1 gamma-glutamyltransferase light chain 1
GHR growth hormone receptor
GIF gastric intrinsic factor (vitamin B synthesis)
GJC1 gap junction protein, gamma 1, 45kDa
GPALPP1 GPALPP motifs containing 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
HOXC5 homeobox C5
HSPA1L heat shock 70kDa protein 1-like
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IMPG2 interphotoreceptor matrix proteoglycan 2
KIF13A kinesin family member 13A
KLHL28 kelch-like family member 28
KRT4 keratin 4, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
LRRK1 leucine-rich repeat kinase 1
LYRM9 LYR motif containing 9
MAPK10 mitogen-activated protein kinase 10
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEGF8 multiple EGF-like-domains 8
MEOX1 mesenchyme homeobox 1
MLXIPL MLX interacting protein-like
MORN1 MORN repeat containing 1
MT1M metallothionein 1M
MXRA8 matrix-remodelling associated 8
NDNF neuron-derived neurotrophic factor
NUBP2 nucleotide binding protein 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
ODF2 outer dense fiber of sperm tails 2
OR7C1 olfactory receptor, family 7, subfamily C, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PAIP2B poly(A) binding protein interacting protein 2B
PARP6 poly (ADP-ribose) polymerase family, member 6
PEX26 peroxisomal biogenesis factor 26
PGAM2 phosphoglycerate mutase 2 (muscle)
PGPEP1 pyroglutamyl-peptidase I
PLA2G3 phospholipase A2, group III
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PRL prolactin
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB40AL RAB40A, member RAS oncogene family-like
REC8 REC8 meiotic recombination protein
S100A3 S100 calcium binding protein A3
SEC14L5 SEC14-like 5 (S. cerevisiae)
SLC17A2 solute carrier family 17, member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
STARD5 StAR-related lipid transfer (START) domain containing 5
STRN striatin, calmodulin binding protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCF15 transcription factor 15 (basic helix-loop-helix)
TDRD12 tudor domain containing 12
TOM1L2 target of myb1-like 2 (chicken)
TSC22D4 TSC22 domain family, member 4
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA3C tubulin, alpha 3c
ZFP30 ZFP30 zinc finger protein
ZNF215 zinc finger protein 215
ZNF286A zinc finger protein 286A
ZNF343 zinc finger protein 343
ZNF442 zinc finger protein 442
ZNF506 zinc finger protein 506
ZNF606 zinc finger protein 606