orlistat-6383 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the orlistat-6383 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ALPK1 alpha-kinase 1
ATF7IP activating transcription factor 7 interacting protein
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BIRC3 baculoviral IAP repeat containing 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C10ORF12 chromosome 10 open reading frame 12
C5AR1 complement component 5a receptor 1
CCDC30 coiled-coil domain containing 30
CCDC85B coiled-coil domain containing 85B
CDK17 cyclin-dependent kinase 17
CEMP1 cementum protein 1
CES3 carboxylesterase 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLSTN3 calsyntenin 3
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL9A3 collagen, type IX, alpha 3
CREBZF CREB/ATF bZIP transcription factor
CYHR1 cysteine/histidine-rich 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPF1 D4, zinc and double PHD fingers family 1
E2F2 E2F transcription factor 2
EHD2 EH-domain containing 2
ELP6 elongator acetyltransferase complex subunit 6
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FGF5 fibroblast growth factor 5
FLJ11710 uncharacterized protein FLJ11710
FXYD2 FXYD domain containing ion transport regulator 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
GMPR guanosine monophosphate reductase
GP6 glycoprotein VI (platelet)
GPR15 G protein-coupled receptor 15
GUCA1B guanylate cyclase activator 1B (retina)
HFE hemochromatosis
HHAT hedgehog acyltransferase
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPS1 Hermansky-Pudlak syndrome 1
ICA1 islet cell autoantigen 1, 69kDa
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIF1C kinesin family member 1C
KLHL28 kelch-like family member 28
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC390998 ribosomal protein L10 pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAN1C1 mannosidase, alpha, class 1C, member 1
MCFD2 multiple coagulation factor deficiency 2
MEGF6 multiple EGF-like-domains 6
MFAP3L microfibrillar-associated protein 3-like
MMP3 matrix metallopeptidase 3
MST1R macrophage stimulating 1 receptor
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NEUROD4 neuronal differentiation 4
NRF1 nuclear respiratory factor 1
NTN1 netrin 1
PCDH9 protocadherin 9
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKNOX2 PBX/knotted 1 homeobox 2
PLEC plectin
POPDC3 popeye domain containing 3
POU2F2 POU class 2 homeobox 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRAMEF12 PRAME family member 12
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB6B RAB6B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARG retinoic acid receptor, gamma
RASL11B RAS-like, family 11, member B
RERE arginine-glutamic acid dipeptide (RE) repeats
RIMS2 regulating synaptic membrane exocytosis 2
RNF6 ring finger protein (C3H2C3 type) 6
RPH3A rabphilin 3A
RUNX1 runt-related transcription factor 1
SAGE1 sarcoma antigen 1
SARM1 sterile alpha and TIR motif containing 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SP100 SP100 nuclear antigen
SRCAP Snf2-related CREBBP activator protein
SRRT serrate, RNA effector molecule
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TRIM29 tripartite motif containing 29
TROVE2 TROVE domain family, member 2
WDTC1 WD and tetratricopeptide repeats 1
ZNF747 zinc finger protein 747
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIPOQ adiponectin, C1Q and collagen domain containing
ALOX15 arachidonate 15-lipoxygenase
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
BTNL2 butyrophilin-like 2
C11ORF1 chromosome 11 open reading frame 1
C5ORF42 chromosome 5 open reading frame 42
CCDC33 coiled-coil domain containing 33
CCDC57 coiled-coil domain containing 57
CCL22 chemokine (C-C motif) ligand 22
CD53 CD53 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CELF3 CUGBP, Elav-like family member 3
CLCN6 chloride channel, voltage-sensitive 6
CRMP1 collapsin response mediator protein 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGCR6L DiGeorge syndrome critical region gene 6-like
DNAI2 dynein, axonemal, intermediate chain 2
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNASE1L3 deoxyribonuclease I-like 3
DYM dymeclin
ELSPBP1 epididymal sperm binding protein 1
EN2 engrailed homeobox 2
ETV4 ets variant 4
F13A1 coagulation factor XIII, A1 polypeptide
FAM131B family with sequence similarity 131, member B
FAM212B family with sequence similarity 212, member B
FBXO4 F-box protein 4
FFAR2 free fatty acid receptor 2
FRS2 fibroblast growth factor receptor substrate 2
FXYD5 FXYD domain containing ion transport regulator 5
GGTLC1 gamma-glutamyltransferase light chain 1
GK2 glycerol kinase 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR65 G protein-coupled receptor 65
GRAMD1C GRAM domain containing 1C
GSTTP1 glutathione S-transferase theta pseudogene 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HYAL3 hyaluronoglucosaminidase 3
IGSF6 immunoglobulin superfamily, member 6
IL2RG interleukin 2 receptor, gamma
KCNIP1 Kv channel interacting protein 1
KDM8 lysine (K)-specific demethylase 8
KLHL3 kelch-like family member 3
KLK11 kallikrein-related peptidase 11
LCT lactase
LEFTY1 left-right determination factor 1
LEFTY2 left-right determination factor 2
LHB luteinizing hormone beta polypeptide
LIFR leukemia inhibitory factor receptor alpha
LINC01587 long intergenic non-protein coding RNA 1587
LRP4 low density lipoprotein receptor-related protein 4
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAGEB2 melanoma antigen family B2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MORC1 MORC family CW-type zinc finger 1
NNAT neuronatin
NOL12 nucleolar protein 12
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX6 paired box 6
PCDHB11 protocadherin beta 11
POLL polymerase (DNA directed), lambda
POU3F2 POU class 3 homeobox 2
R3HCC1L R3H domain and coiled-coil containing 1-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGSL1 regulator of G-protein signaling like 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB1 SATB homeobox 1
SDC3 syndecan 3
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SH2D3C SH2 domain containing 3C
SHARPIN SHANK-associated RH domain interactor
SHH sonic hedgehog
SKI SKI proto-oncogene
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4
SORCS3 sortilin-related VPS10 domain containing receptor 3
SP1 Sp1 transcription factor
STAB2 stabilin 2
SYT13 synaptotagmin XIII
TCP10 t-complex 10
TLR2 toll-like receptor 2
TOR4A torsin family 4, member A
USP27X ubiquitin specific peptidase 27, X-linked
USP29 ubiquitin specific peptidase 29
WNT10B wingless-type MMTV integration site family, member 10B
YPEL1 yippee-like 1 (Drosophila)
YY2 YY2 transcription factor
ZFHX4 zinc finger homeobox 4
ZNF358 zinc finger protein 358
ZNF613 zinc finger protein 613
ZSWIM1 zinc finger, SWIM-type containing 1