optic neuritis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision. (Human Disease Ontology, DOID_1210)
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Genes

81 genes co-occuring with the disease optic neuritis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
AQP4 aquaporin 4 2.86473
MOG myelin oligodendrocyte glycoprotein 2.00056
MBP myelin basic protein 1.76547
IFNB1 interferon, beta 1, fibroblast 1.51721
DPYSL5 dihydropyrimidinase-like 5 1.37469
CCNDBP1 cyclin D-type binding-protein 1 1.04672
HLA-C major histocompatibility complex, class I, C 0.854449
POU4F1 POU class 4 homeobox 1 0.788442
MAG myelin associated glycoprotein 0.757378
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.703938
NEFH neurofilament, heavy polypeptide 0.70233
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.689092
CD4 CD4 molecule 0.682294
CAST calpastatin 0.67312
CLIP1 CAP-GLY domain containing linker protein 1 0.638676
RCVRN recoverin 0.635921
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.603811
CNTF ciliary neurotrophic factor 0.6003
SIRT1 sirtuin 1 0.587833
GPR15 G protein-coupled receptor 15 0.566831
RANGRF RAN guanine nucleotide release factor 0.552851
DOCK3 dedicator of cytokinesis 3 0.523045
CLDN11 claudin 11 0.515725
PRLH prolactin releasing hormone 0.509576
TNF tumor necrosis factor 0.491597
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.484744
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.474119
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.472982
MOBP myelin-associated oligodendrocyte basic protein 0.46466
HSPG2 heparan sulfate proteoglycan 2 0.435651
CAT catalase 0.431519
HCRT hypocretin (orexin) neuropeptide precursor 0.427015
AMPH amphiphysin 0.402318
CXCR3 chemokine (C-X-C motif) receptor 3 0.396353
AIF1 allograft inflammatory factor 1 0.394863
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.390769
ALB albumin 0.382966
SOD3 superoxide dismutase 3, extracellular 0.380739
CD80 CD80 molecule 0.365193
SYCN syncollin 0.360026
IL4 interleukin 4 0.351555
MRAP melanocortin 2 receptor accessory protein 0.348614
GSAP gamma-secretase activating protein 0.346042
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.345308
SAG S-antigen; retina and pineal gland (arrestin) 0.340173
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.335778
S100B S100 calcium binding protein B 0.307033
MAPK1 mitogen-activated protein kinase 1 0.295132
PNMA2 paraneoplastic Ma antigen 2 0.292975
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.281153
POMC proopiomelanocortin 0.271174
BDNF brain-derived neurotrophic factor 0.263722
TES testin LIM domain protein 0.243995
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.237009
ACRV1 acrosomal vesicle protein 1 0.230409
MON1A MON1 secretory trafficking family member A 0.230063
WDR36 WD repeat domain 36 0.226607
SLC22A18 solute carrier family 22, member 18 0.22454
MLN motilin 0.203768
HESX1 HESX homeobox 1 0.19742
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.196139
OSCAR osteoclast associated, immunoglobulin-like receptor 0.194865
CS citrate synthase 0.185985
OMD osteomodulin 0.178126
PANX1 pannexin 1 0.177029
CDK11A cyclin-dependent kinase 11A 0.166995
ACE angiotensin I converting enzyme 0.166039
MRI1 methylthioribose-1-phosphate isomerase 1 0.161716
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.161139
CA2 carbonic anhydrase II 0.158994
IFNG interferon, gamma 0.156225
FLNA filamin A, alpha 0.155306
EXTL3 exostosin-like glycosyltransferase 3 0.142127
WDFY2 WD repeat and FYVE domain containing 2 0.140887
ANG angiogenin, ribonuclease, RNase A family, 5 0.140472
ERBB2 erb-b2 receptor tyrosine kinase 2 0.140176
CRP C-reactive protein, pentraxin-related 0.137147
LYZ lysozyme 0.136556
VEGFA vascular endothelial growth factor A 0.13074
LTF lactotransferrin 0.129927
CP ceruloplasmin (ferroxidase) 0.126564