optic cup Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The optic vesicle after invaginating to form a 2-layered cup from which the retina and pigmented layer of the eye will develop. (BRENDA Tissue and Enzyme Source Ontology, BTO_0005351)
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Genes

194 proteins co-occuring with the tissue optic cup in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
VAX2 ventral anterior homeobox 2 1.77278
RHO rhodopsin 1.77027
PAX6 paired box 6 1.68404
TBX5 T-box 5 1.5888
RBP3 retinol binding protein 3, interstitial 1.57258
PAX2 paired box 2 1.5138
LHX2 LIM homeobox 2 1.47335
MITF microphthalmia-associated transcription factor 1.43987
VAX1 ventral anterior homeobox 1 1.43153
AANAT aralkylamine N-acetyltransferase 1.42506
MAB21L2 mab-21-like 2 (C. elegans) 1.37499
RPE65 retinal pigment epithelium-specific protein 65kDa 1.34451
WNT2B wingless-type MMTV integration site family, member 2B 1.33817
VSX2 visual system homeobox 2 1.31874
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 1.29265
BMP4 bone morphogenetic protein 4 1.24967
OTX2 orthodenticle homeobox 2 1.24565
TYR tyrosinase 1.23405
RDH8 retinol dehydrogenase 8 (all-trans) 1.19667
SIX3 SIX homeobox 3 1.18823
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 1.16604
SHISA2 shisa family member 2 1.11995
SHH sonic hedgehog 1.11022
TBX2 T-box 2 1.07927
MNX1 motor neuron and pancreas homeobox 1 1.00938
FAM161A family with sequence similarity 161, member A 1.0037
PALMD palmdelphin 0.985859
FGF8 fibroblast growth factor 8 (androgen-induced) 0.984991
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.967225
NR2E1 nuclear receptor subfamily 2, group E, member 1 0.934054
NARF nuclear prelamin A recognition factor 0.92805
BMP7 bone morphogenetic protein 7 0.885862
BBS5 Bardet-Biedl syndrome 5 0.882474
CRYGS crystallin, gamma S 0.847904
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.836575
GLI3 GLI family zinc finger 3 0.828616
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.820248
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.803961
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.794792
CERKL ceramide kinase-like 0.794375
NOG noggin 0.794375
MAB21L1 mab-21-like 1 (C. elegans) 0.770685
ATOH7 atonal homolog 7 (Drosophila) 0.759914
MSX1 msh homeobox 1 0.757845
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.749992
SMOC1 SPARC related modular calcium binding 1 0.747927
FZD1 frizzled class receptor 1 0.745039
ERF Ets2 repressor factor 0.742152
RGR retinal G protein coupled receptor 0.726097
LIN7C lin-7 homolog C (C. elegans) 0.724041
DGKQ diacylglycerol kinase, theta 110kDa 0.70886
TYRP1 tyrosinase-related protein 1 0.706812
MBNL2 muscleblind-like splicing regulator 2 0.694128
KIAA0586 KIAA0586 0.690859
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.675357
FGF1 fibroblast growth factor 1 (acidic) 0.668436
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.657866
RNF2 ring finger protein 2 0.65746
OTX1 orthodenticle homeobox 1 0.641643
RDH10 retinol dehydrogenase 10 (all-trans) 0.631123
RLBP1 retinaldehyde binding protein 1 0.629101
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.617393
GYLTL1B glycosyltransferase-like 1B 0.610943
TFR2 transferrin receptor 2 0.605306
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.605306
WNT7B wingless-type MMTV integration site family, member 7B 0.601283
SERP1 stress-associated endoplasmic reticulum protein 1 0.597263
PITX3 paired-like homeodomain 3 0.592845
NUMBL numb homolog (Drosophila)-like 0.582019
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.581218
FOXE3 forkhead box E3 0.579216
BCOR BCL6 corepressor 0.577215
BEST1 bestrophin 1 0.575616
PARD3 par-3 family cell polarity regulator 0.573217
CRYAA crystallin, alpha A 0.572018
MNDA myeloid cell nuclear differentiation antigen 0.57042
WNT9A wingless-type MMTV integration site family, member 9A 0.568823
SOX3 SRY (sex determining region Y)-box 3 0.566828
LHX5 LIM homeobox 5 0.556467
MFRP membrane frizzled-related protein 0.54812
MEIS2 Meis homeobox 2 0.536625
GDF5 growth differentiation factor 5 0.530298
SOX13 SRY (sex determining region Y)-box 13 0.529903
COL9A1 collagen, type IX, alpha 1 0.523588
WNT16 wingless-type MMTV integration site family, member 16 0.520829
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.520829
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.511384
PAX3 paired box 3 0.510599
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.510206
PID1 phosphotyrosine interaction domain containing 1 0.509813
SAG S-antigen; retina and pineal gland (arrestin) 0.508242
ELOVL4 ELOVL fatty acid elongase 4 0.507849
HPS1 Hermansky-Pudlak syndrome 1 0.497657
FOXG1 forkhead box G1 0.491791
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.490229
RTKN rhotekin 0.489838
ISL1 ISL LIM homeobox 1 0.487496
VLDLR very low density lipoprotein receptor 0.484376
FGFR1 fibroblast growth factor receptor 1 0.481648
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.477756
MAX MYC associated factor X 0.472315
SLC7A4 solute carrier family 7, member 4 0.471927
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.468436
RCVRN recoverin 0.466885
IL18RAP interleukin 18 receptor accessory protein 0.465335
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.462626
AXIN2 axin 2 0.455284
WNT3A wingless-type MMTV integration site family, member 3A 0.448731
RND1 Rho family GTPase 1 0.443731
WNT8B wingless-type MMTV integration site family, member 8B 0.442194
NOTCH1 notch 1 0.437972
DGKA diacylglycerol kinase, alpha 80kDa 0.432991
PITX2 paired-like homeodomain 2 0.432991
TBXAS1 thromboxane A synthase 1 (platelet) 0.423818
FZD5 frizzled class receptor 5 0.420766
BFSP2 beaded filament structural protein 2, phakinin 0.41848
GLI2 GLI family zinc finger 2 0.413532
SFRP1 secreted frizzled-related protein 1 0.408972
SCN3A sodium channel, voltage gated, type III alpha subunit 0.406315
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.397222
ARSA arylsulfatase A 0.394953
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.394197
NDP Norrie disease (pseudoglioma) 0.38439
CBLN1 cerebellin 1 precursor 0.38326
PTCH2 patched 2 0.378748
SMO smoothened, frizzled class receptor 0.377621
EFNB2 ephrin-B2 0.377245
NOTCH2NL notch 2 N-terminal like 0.377245
MSX2 msh homeobox 2 0.375368
NOTCH2 notch 2 0.374243
LHX1 LIM homeobox 1 0.367502
GAS1 growth arrest-specific 1 0.36526
SOX10 SRY (sex determining region Y)-box 10 0.36302
MBNL1 muscleblind-like splicing regulator 1 0.361155
TSPO translocator protein (18kDa) 0.358174
WNT6 wingless-type MMTV integration site family, member 6 0.351856
FGFR2 fibroblast growth factor receptor 2 0.347778
WNT5A wingless-type MMTV integration site family, member 5A 0.345188
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.338914
SOX11 SRY (sex determining region Y)-box 11 0.333028
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.332294
CHAT choline O-acetyltransferase 0.332294
CHD7 chromodomain helicase DNA binding protein 7 0.326432
DPP7 dipeptidyl-peptidase 7 0.317315
CA10 carbonic anhydrase X 0.314772
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.312595
LIM2 lens intrinsic membrane protein 2, 19kDa 0.31187
DLX1 distal-less homeobox 1 0.310059
SIX4 SIX homeobox 4 0.302118
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.301398
CDON cell adhesion associated, oncogene regulated 0.298165
DCT dopachrome tautomerase 0.297089
ARHGAP35 Rho GTPase activating protein 35 0.292079
RET ret proto-oncogene 0.289939
FOXC1 forkhead box C1 0.287092
ARSB arylsulfatase B 0.282483
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.268828
PCNA proliferating cell nuclear antigen 0.266413
HFE hemochromatosis 0.266069
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.264011
MIP major intrinsic protein of lens fiber 0.262986
DNTT DNA nucleotidylexotransferase 0.259591
HFE2 hemochromatosis type 2 (juvenile) 0.257572
PRB3 proline-rich protein BstNI subfamily 3 0.257237
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.256902
NEUROD1 neuronal differentiation 1 0.252919
SETD1A SET domain containing 1A 0.252261
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.250627
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.250301
STX8 syntaxin 8 0.247399
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.245491
MYO7A myosin VIIA 0.245175
FN1 fibronectin 1 0.243605
ASPH aspartate beta-hydroxylase 0.242054
WNT10A wingless-type MMTV integration site family, member 10A 0.241132
NEUROG2 neurogenin 2 0.23781
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.237216
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.236921
SOX1 SRY (sex determining region Y)-box 1 0.235748
CAST calpastatin 0.232039
GLI1 GLI family zinc finger 1 0.231482
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.229299
GLB1 galactosidase, beta 1 0.229299
TRAF1 TNF receptor-associated factor 1 0.228764
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.226667
ADA adenosine deaminase 0.224645
GREM2 gremlin 2, DAN family BMP antagonist 0.222224
NRP2 neuropilin 2 0.221989
NCOA2 nuclear receptor coactivator 2 0.21883
CXCL14 chemokine (C-X-C motif) ligand 14 0.217554
REST RE1-silencing transcription factor 0.217554
GNRH2 gonadotropin-releasing hormone 2 0.21673
E2F4 E2F transcription factor 4, p107/p130-binding 0.21573
PDC phosducin 0.215534