ondansetron-6153 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the ondansetron-6153 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ADARB1 adenosine deaminase, RNA-specific, B1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP26 Rho GTPase activating protein 26
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATN1 atrophin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BANK1 B-cell scaffold protein with ankyrin repeats 1
BDNF brain-derived neurotrophic factor
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C1QL1 complement component 1, q subcomponent-like 1
CA11 carbonic anhydrase XI
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD1A CD1a molecule
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNOT3 CCR4-NOT transcription complex, subunit 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
E2F2 E2F transcription factor 2
EPHB2 EPH receptor B2
ERICH1 glutamate-rich 1
ESM1 endothelial cell-specific molecule 1
ESR1 estrogen receptor 1
FAM120C family with sequence similarity 120C
FBXO2 F-box protein 2
FGF1 fibroblast growth factor 1 (acidic)
FMO6P flavin containing monooxygenase 6 pseudogene
FRMD1 FERM domain containing 1
FUBP1 far upstream element (FUSE) binding protein 1
GAREM GRB2 associated, regulator of MAPK1
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF5 growth differentiation factor 5
GIPR gastric inhibitory polypeptide receptor
GRIP2 glutamate receptor interacting protein 2
GSN-AS1 GSN antisense RNA 1
GSTM5 glutathione S-transferase mu 5
GYPB glycophorin B (MNS blood group)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL11 interleukin 11
IL17RB interleukin 17 receptor B
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIF25-AS1 KIF25 antisense RNA 1
KLF12 Kruppel-like factor 12
KLK7 kallikrein-related peptidase 7
KSR1 kinase suppressor of ras 1
LAMA2 laminin, alpha 2
LHX2 LIM homeobox 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP4 latent transforming growth factor beta binding protein 4
MED25 mediator complex subunit 25
MLH3 mutL homolog 3
MOB3B MOB kinase activator 3B
MTCP1 mature T-cell proliferation 1
NIPAL2 NIPA-like domain containing 2
NPTXR neuronal pentraxin receptor
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2B olfactomedin-like 2B
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PARP11 poly (ADP-ribose) polymerase family, member 11
PDE4DIP phosphodiesterase 4D interacting protein
PEX3 peroxisomal biogenesis factor 3
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLCE1 phospholipase C, epsilon 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40AL RAB40A, member RAS oncogene family-like
REC8 REC8 meiotic recombination protein
RYR2 ryanodine receptor 2 (cardiac)
SCAND2P SCAN domain containing 2 pseudogene
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SIDT2 SID1 transmembrane family, member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLITRK3 SLIT and NTRK-like family, member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNCG synuclein, gamma (breast cancer-specific protein 1)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST7L suppression of tumorigenicity 7 like
STAP1 signal transducing adaptor family member 1
THAP9 THAP domain containing 9
TIMELESS timeless circadian clock
TK2 thymidine kinase 2, mitochondrial
TMEM2 transmembrane protein 2
TYRP1 tyrosinase-related protein 1
VSIG10 V-set and immunoglobulin domain containing 10
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
AOAH acyloxyacyl hydrolase (neutrophil)
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF35 chromosome 1 open reading frame 35
C5ORF45 chromosome 5 open reading frame 45
C9ORF9 chromosome 9 open reading frame 9
CBR3 carbonyl reductase 3
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CEP170B centrosomal protein 170B
CLIP2 CAP-GLY domain containing linker protein 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRMP1 collapsin response mediator protein 1
CYB5R2 cytochrome b5 reductase 2
DENND5B DENN/MADD domain containing 5B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DTX2 deltex 2, E3 ubiquitin ligase
ENO3 enolase 3 (beta, muscle)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM214B family with sequence similarity 214, member B
FGFBP1 fibroblast growth factor binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS3 fibroblast growth factor receptor substrate 3
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GPR182 G protein-coupled receptor 182
GSPT2 G1 to S phase transition 2
GSTA4 glutathione S-transferase alpha 4
HIST1H3B histone cluster 1, H3b
HLA-DMB major histocompatibility complex, class II, DM beta
HSPB8 heat shock 22kDa protein 8
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA14 interferon, alpha 14
IGLV1-44 immunoglobulin lambda variable 1-44
IL12RB1 interleukin 12 receptor, beta 1
INF2 inverted formin, FH2 and WH2 domain containing
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0513 KIAA0513
LIME1 Lck interacting transmembrane adaptor 1
LOC730101 uncharacterized LOC730101
LOXL3 lysyl oxidase-like 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP6D1 MAP6 domain containing 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MTMR12 myotubularin related protein 12
NKX3-2 NK3 homeobox 2
NOD2 nucleotide-binding oligomerization domain containing 2
NSUN3 NOP2/Sun domain family, member 3
NSUN6 NOP2/Sun domain family, member 6
OLAH oleoyl-ACP hydrolase
OR1G1 olfactory receptor, family 1, subfamily G, member 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
PCDHGB5 protocadherin gamma subfamily B, 5
PGBD5 piggyBac transposable element derived 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PIAS3 protein inhibitor of activated STAT, 3
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G3 phospholipase A2, group III
PLD3 phospholipase D family, member 3
PLP1 proteolipid protein 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRF1 perforin 1 (pore forming protein)
PROL1 proline rich, lacrimal 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3D RAB3D, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
SALL2 spalt-like transcription factor 2
SETD1A SET domain containing 1A
SIGLEC15 sialic acid binding Ig-like lectin 15
SMR3A submaxillary gland androgen regulated protein 3A
TEX40 testis expressed 40
THBS3 thrombospondin 3
TNS2 tensin 2
TP53I3 tumor protein p53 inducible protein 3
TUBA3C tubulin, alpha 3c
USP18 ubiquitin specific peptidase 18
VN1R1 vomeronasal 1 receptor 1
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZFP37 ZFP37 zinc finger protein
ZIC3 Zic family member 3
ZNF276 zinc finger protein 276