ofloxacin-4696 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the ofloxacin-4696 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AGFG1 ArfGAP with FG repeats 1
AK1 adenylate kinase 1
ALCAM activated leukocyte cell adhesion molecule
ALDOB aldolase B, fructose-bisphosphate
ARHGAP24 Rho GTPase activating protein 24
B3GAT1 beta-1,3-glucuronyltransferase 1
BTG2 BTG family, member 2
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC186 coiled-coil domain containing 186
CD7 CD7 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK13 cyclin-dependent kinase 13
CIZ1 CDKN1A interacting zinc finger protein 1
CNGB3 cyclic nucleotide gated channel beta 3
COL8A1 collagen, type VIII, alpha 1
CPN2 carboxypeptidase N, polypeptide 2
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAI2 dynein, axonemal, intermediate chain 2
DNM3 dynamin 3
EDNRA endothelin receptor type A
EFNB3 ephrin-B3
EFR3B EFR3 homolog B (S. cerevisiae)
EPHB2 EPH receptor B2
ETV6 ets variant 6
FGFR1 fibroblast growth factor receptor 1
GJA4 gap junction protein, alpha 4, 37kDa
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GPATCH3 G patch domain containing 3
GPR137 G protein-coupled receptor 137
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4A histone cluster 1, H4a
HLF hepatic leukemia factor
HOXB5 homeobox B5
IGL immunoglobulin lambda locus
IL5RA interleukin 5 receptor, alpha
IQCK IQ motif containing K
ITPK1 inositol-tetrakisphosphate 1-kinase
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
LAMA4 laminin, alpha 4
LIN7A lin-7 homolog A (C. elegans)
LOXL2 lysyl oxidase-like 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MCAM melanoma cell adhesion molecule
MED31 mediator complex subunit 31
MID1 midline 1
MIER2 mesoderm induction early response 1, family member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NRN1 neuritin 1
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PAPPA2 pappalysin 2
PARVA parvin, alpha
PCDHA5 protocadherin alpha 5
PCDHGB5 protocadherin gamma subfamily B, 5
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PIP prolactin-induced protein
PLAC4 placenta-specific 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
POU5F1B POU class 5 homeobox 1B
PRDM2 PR domain containing 2, with ZNF domain
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QSER1 glutamine and serine rich 1
RBM26 RNA binding motif protein 26
RPL35A ribosomal protein L35a
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNED1 sushi, nidogen and EGF-like domains 1
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA5L1 spermatogenesis associated 5-like 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBX3 T-box 3
THEMIS2 thymocyte selection associated family member 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIM10 tripartite motif containing 10
TUBA3C tubulin, alpha 3c
VAV2 vav 2 guanine nucleotide exchange factor
WIPF1 WAS/WASL interacting protein family, member 1
WNK1 WNK lysine deficient protein kinase 1
ZNF204P zinc finger protein 204, pseudogene
ZNF304 zinc finger protein 304
ZNF41 zinc finger protein 41
ZNF415 zinc finger protein 415
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARC activity-regulated cytoskeleton-associated protein
BGLAP bone gamma-carboxyglutamate (gla) protein
C14ORF93 chromosome 14 open reading frame 93
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC9 coiled-coil domain containing 9
CD3D CD3d molecule, delta (CD3-TCR complex)
CDADC1 cytidine and dCMP deaminase domain containing 1
CEL carboxyl ester lipase
CENPO centromere protein O
CIDEC cell death-inducing DFFA-like effector c
CIR1 corepressor interacting with RBPJ, 1
CLIC2 chloride intracellular channel 2
CORO7 coronin 7
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM204A family with sequence similarity 204, member A
FUZ fuzzy planar cell polarity protein
GLRA1 glycine receptor, alpha 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPC3 glypican 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AL histone cluster 1, H2al
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IPO8 importin 8
KIF13A kinesin family member 13A
KRT8P12 keratin 8 pseudogene 12
LAMB2 laminin, beta 2 (laminin S)
LHX6 LIM homeobox 6
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC23 leucine rich repeat containing 23
MOCS3 molybdenum cofactor synthesis 3
MTERF4 mitochondrial transcription termination factor 4
MXD3 MAX dimerization protein 3
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKAIN1 Na+/K+ transporting ATPase interacting 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUPL2 nucleoporin like 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAIP2B poly(A) binding protein interacting protein 2B
PLAT plasminogen activator, tissue
PMEL premelanosome protein
POLH polymerase (DNA directed), eta
PP14571 uncharacterized LOC100130449
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPRS protein tyrosine phosphatase, receptor type, S
RAB33B RAB33B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNF208 ring finger protein 208
SETD8 SET domain containing (lysine methyltransferase) 8
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPAG7 sperm associated antigen 7
SPATA2L spermatogenesis associated 2-like
SPRR2B small proline-rich protein 2B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TDRD12 tudor domain containing 12
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM120B transmembrane protein 120B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM53 transmembrane protein 53
TNRC6B trinucleotide repeat containing 6B
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
VASH1 vasohibin 1
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR76 WD repeat domain 76
ZBTB22 zinc finger and BTB domain containing 22
ZBTB39 zinc finger and BTB domain containing 39
ZNF219 zinc finger protein 219
ZNF428 zinc finger protein 428