ofloxacin-3673 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the ofloxacin-3673 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ADAM23 ADAM metallopeptidase domain 23
ADIPOQ adiponectin, C1Q and collagen domain containing
AJAP1 adherens junctions associated protein 1
ANGPT1 angiopoietin 1
APOB apolipoprotein B
ATG10 autophagy related 10
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GAT1 beta-1,3-glucuronyltransferase 1
BAIAP2 BAI1-associated protein 2
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCR2 chemokine (C-C motif) receptor 2
CD5 CD5 molecule
CFAP45 cilia and flagella associated protein 45
COPZ2 coatomer protein complex, subunit zeta 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRTC1 CREB regulated transcription coactivator 1
CT62 cancer/testis antigen 62
CYBB cytochrome b-245, beta polypeptide
DAPK2 death-associated protein kinase 2
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
EMC3 ER membrane protein complex subunit 3
EPHA5 EPH receptor A5
FGL2 fibrinogen-like 2
FKBP10 FK506 binding protein 10, 65 kDa
FOXO4 forkhead box O4
FZD1 frizzled class receptor 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALC galactosylceramidase
GJA4 gap junction protein, alpha 4, 37kDa
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR27 G protein-coupled receptor 27
GRM1 glutamate receptor, metabotropic 1
GRM7 glutamate receptor, metabotropic 7
HAL histidine ammonia-lyase
HBE1 hemoglobin, epsilon 1
IPCEF1 interaction protein for cytohesin exchange factors 1
IRF4 interferon regulatory factor 4
ITGA7 integrin, alpha 7
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAM2 junctional adhesion molecule 2
KLHL18 kelch-like family member 18
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT1 keratin 1, type II
KRT24 keratin 24, type I
KRTAP1-1 keratin associated protein 1-1
LAMP5 lysosomal-associated membrane protein family, member 5
LCAT lecithin-cholesterol acyltransferase
LDAH lipid droplet associated hydrolase
LINC00312 long intergenic non-protein coding RNA 312
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MED16 mediator complex subunit 16
MEF2D myocyte enhancer factor 2D
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYH14 myosin, heavy chain 14, non-muscle
N4BP1 NEDD4 binding protein 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP1 neuropilin 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDZK1IP1 PDZK1 interacting protein 1
PER2 period circadian clock 2
PHOX2B paired-like homeobox 2b
POU3F4 POU class 3 homeobox 4
PRKCE protein kinase C, epsilon
PRPH2 peripherin 2 (retinal degeneration, slow)
PTEN phosphatase and tensin homolog
PTPN7 protein tyrosine phosphatase, non-receptor type 7
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD23B RAD23 homolog B (S. cerevisiae)
RANBP3 RAN binding protein 3
SAMD4A sterile alpha motif domain containing 4A
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SNN stannin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRR2B small proline-rich protein 2B
STARD8 StAR-related lipid transfer (START) domain containing 8
STAT2 signal transducer and activator of transcription 2, 113kDa
SYT2 synaptotagmin II
TACR1 tachykinin receptor 1
TBX5 T-box 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBAL3 tubulin, alpha-like 3
UPK1B uroplakin 1B
WIPF1 WAS/WASL interacting protein family, member 1
ZFHX2 zinc finger homeobox 2
ZNF345 zinc finger protein 345
ZNF362 zinc finger protein 362

decreased expression

Symbol Name
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
ANXA2P1 annexin A2 pseudogene 1
ARC activity-regulated cytoskeleton-associated protein
ARMCX2 armadillo repeat containing, X-linked 2
ATAD5 ATPase family, AAA domain containing 5
ATXN2 ataxin 2
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMKMT calmodulin-lysine N-methyltransferase
CCDC106 coiled-coil domain containing 106
CCDC121 coiled-coil domain containing 121
CCNJL cyclin J-like
CDHR2 cadherin-related family member 2
CDON cell adhesion associated, oncogene regulated
CLEC4E C-type lectin domain family 4, member E
CNTLN centlein, centrosomal protein
COBL cordon-bleu WH2 repeat protein
CORO2A coronin, actin binding protein, 2A
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEAF1 DEAF1 transcription factor
DHRS9 dehydrogenase/reductase (SDR family) member 9
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DIO3 deiodinase, iodothyronine, type III
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP2 dual specificity phosphatase 2
EFNB1 ephrin-B1
EPHX2 epoxide hydrolase 2, cytoplasmic
EXOC6B exocyst complex component 6B
FBXL2 F-box and leucine-rich repeat protein 2
FLJ21369 uncharacterized protein FLJ21369
GBP2 guanylate binding protein 2, interferon-inducible
GJC1 gap junction protein, gamma 1, 45kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR176 G protein-coupled receptor 176
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
HIST1H3C histone cluster 1, H3c
IL22 interleukin 22
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KRT4 keratin 4, type II
LAMC3 laminin, gamma 3
LIME1 Lck interacting transmembrane adaptor 1
LOC157562 uncharacterized LOC157562
LRP5L low density lipoprotein receptor-related protein 5-like
MAK male germ cell-associated kinase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K7CL MAP3K7 C-terminal like
MBNL3 muscleblind-like splicing regulator 3
MEGF8 multiple EGF-like-domains 8
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NCAPH non-SMC condensin I complex, subunit H
NDP Norrie disease (pseudoglioma)
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PDGFRL platelet-derived growth factor receptor-like
PEX11A peroxisomal biogenesis factor 11 alpha
PHF14 PHD finger protein 14
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PODXL2 podocalyxin-like 2
POLM polymerase (DNA directed), mu
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKCD protein kinase C, delta
PRPH peripherin
RAB28 RAB28, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHBDD3 rhomboid domain containing 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A3 S100 calcium binding protein A3
SAYSD1 SAYSVFN motif domain containing 1
SETD1A SET domain containing 1A
SMO smoothened, frizzled class receptor
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNRPN small nuclear ribonucleoprotein polypeptide N
SNTG1 syntrophin, gamma 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TBC1D19 TBC1 domain family, member 19
THRAP3 thyroid hormone receptor associated protein 3
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM212 transmembrane protein 212
TUBA3C tubulin, alpha 3c
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
WNT10B wingless-type MMTV integration site family, member 10B
YPEL1 yippee-like 1 (Drosophila)
ZC3H12A zinc finger CCCH-type containing 12A
ZNF573 zinc finger protein 573
ZNF76 zinc finger protein 76