ofloxacin-2340 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ofloxacin-2340 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADA adenosine deaminase
ADD2 adducin 2 (beta)
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APAF1 apoptotic peptidase activating factor 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOC1 apolipoprotein C-I
ARG1 arginase 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BHMT betaine--homocysteine S-methyltransferase
C14ORF93 chromosome 14 open reading frame 93
CD82 CD82 molecule
CDC14A cell division cycle 14A
CDRT1 CMT1A duplicated region transcript 1
CHPF chondroitin polymerizing factor
CHST10 carbohydrate sulfotransferase 10
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTN1 contactin 1
CRTC1 CREB regulated transcription coactivator 1
CSF1 colony stimulating factor 1 (macrophage)
CTNND1 catenin (cadherin-associated protein), delta 1
CTSV cathepsin V
CUL3 cullin 3
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
E2F5 E2F transcription factor 5, p130-binding
EDNRB endothelin receptor type B
ERP44 endoplasmic reticulum protein 44
EXOSC2 exosome component 2
FGF5 fibroblast growth factor 5
FGGY FGGY carbohydrate kinase domain containing
FRMD1 FERM domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPR haptoglobin-related protein
IL1R2 interleukin 1 receptor, type II
IRF2BP1 interferon regulatory factor 2 binding protein 1
KAT8 K(lysine) acetyltransferase 8
KDM4B lysine (K)-specific demethylase 4B
KLHL25 kelch-like family member 25
KRT17 keratin 17, type I
LOC257152 uncharacterized LOC257152
LOC392555 melanoma antigen family C2 pseudogene
LOC647070 uncharacterized LOC647070
LOXL3 lysyl oxidase-like 3
MEFV Mediterranean fever
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NF1 neurofibromin 1
NTF3 neurotrophin 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCDHGB5 protocadherin gamma subfamily B, 5
PCNXL2 pecanex-like 2 (Drosophila)
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PLD1 phospholipase D1, phosphatidylcholine-specific
PMFBP1 polyamine modulated factor 1 binding protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRSS53 protease, serine, 53
PSD3 pleckstrin and Sec7 domain containing 3
PSKH1 protein serine kinase H1
PSPH phosphoserine phosphatase
RAD52 RAD52 homolog (S. cerevisiae)
RALGDS ral guanine nucleotide dissociation stimulator
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REST RE1-silencing transcription factor
RET ret proto-oncogene
S100A6 S100 calcium binding protein A6
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMC4 structural maintenance of chromosomes 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSH3 slingshot protein phosphatase 3
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D30 TBC1 domain family, member 30
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS1 tensin 1
TPMT thiopurine S-methyltransferase
TRD T cell receptor delta locus
TSKU tsukushi, small leucine rich proteoglycan
UBE3B ubiquitin protein ligase E3B
VN1R1 vomeronasal 1 receptor 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZC3H13 zinc finger CCCH-type containing 13
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF202 zinc finger protein 202
ZNF354A zinc finger protein 354A
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACIN1 apoptotic chromatin condensation inducer 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AGO4 argonaute RISC catalytic component 4
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARSB arylsulfatase B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C11ORF21 chromosome 11 open reading frame 21
C1ORF54 chromosome 1 open reading frame 54
CDA cytidine deaminase
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CGRRF1 cell growth regulator with ring finger domain 1
CHMP7 charged multivesicular body protein 7
CIC capicua transcriptional repressor
CIR1 corepressor interacting with RBPJ, 1
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CREB3 cAMP responsive element binding protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DGKD diacylglycerol kinase, delta 130kDa
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DUSP5 dual specificity phosphatase 5
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM172A family with sequence similarity 172, member A
FBXL6 F-box and leucine-rich repeat protein 6
FLCN folliculin
FUZ fuzzy planar cell polarity protein
GIPC1 GIPC PDZ domain containing family, member 1
GMPPB GDP-mannose pyrophosphorylase B
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BF histone cluster 1, H2bf
HYAL2 hyaluronoglucosaminidase 2
IL4R interleukin 4 receptor
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JOSD1 Josephin domain containing 1
KAT2A K(lysine) acetyltransferase 2A
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MANBA mannosidase, beta A, lysosomal
MAPK3 mitogen-activated protein kinase 3
MBNL3 muscleblind-like splicing regulator 3
MEF2D myocyte enhancer factor 2D
MFSD12 major facilitator superfamily domain containing 12
MILR1 mast cell immunoglobulin-like receptor 1
MRPL52 mitochondrial ribosomal protein L52
MTMR12 myotubularin related protein 12
MYO15A myosin XVA
NBEAL2 neurobeachin-like 2
NCF1C neutrophil cytosolic factor 1C pseudogene
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P3H1 prolyl 3-hydroxylase 1
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLS1 plastin 1
PMCH pro-melanin-concentrating hormone
PNMA1 paraneoplastic Ma antigen 1
POR P450 (cytochrome) oxidoreductase
PRKX protein kinase, X-linked
PTGES2 prostaglandin E synthase 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QPCT glutaminyl-peptide cyclotransferase
RAB33B RAB33B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBM47 RNA binding motif protein 47
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SETD8 SET domain containing (lysine methyltransferase) 8
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLFN12 schlafen family member 12
SMR3A submaxillary gland androgen regulated protein 3A
SSBP3 single stranded DNA binding protein 3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TCEA2 transcription elongation factor A (SII), 2
TMEM212 transmembrane protein 212
TRAPPC11 trafficking protein particle complex 11
TTPAL tocopherol (alpha) transfer protein-like
WDR91 WD repeat domain 91
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBED8 zinc finger, BED-type containing 8
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF552 zinc finger protein 552
ZNF629 zinc finger protein 629
ZSCAN9 zinc finger and SCAN domain containing 9