ofloxacin-2302 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ofloxacin-2302 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADD2 adducin 2 (beta)
AHNAK2 AHNAK nucleoprotein 2
AIRE autoimmune regulator
AK1 adenylate kinase 1
AKAP13 A kinase (PRKA) anchor protein 13
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARC activity-regulated cytoskeleton-associated protein
ARHGAP33 Rho GTPase activating protein 33
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
C22ORF46 chromosome 22 open reading frame 46
CA10 carbonic anhydrase X
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD53 CD53 molecule
CD82 CD82 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
COL6A1 collagen, type VI, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DNAH17 dynein, axonemal, heavy chain 17
DNAH9 dynein, axonemal, heavy chain 9
DOC2A double C2-like domains, alpha
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EXOSC1 exosome component 1
FAM155A family with sequence similarity 155, member A
FAM76A family with sequence similarity 76, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FOXN3 forkhead box N3
FRMD1 FERM domain containing 1
FUT2 fucosyltransferase 2 (secretor status included)
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GUK1 guanylate kinase 1
HRH2 histamine receptor H2
IDUA iduronidase, alpha-L-
IGHMBP2 immunoglobulin mu binding protein 2
IL23A interleukin 23, alpha subunit p19
IRS4 insulin receptor substrate 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JAK3 Janus kinase 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDR kinase insert domain receptor
KREMEN2 kringle containing transmembrane protein 2
KRT15 keratin 15, type I
KRT83 keratin 83, type II
LAMB4 laminin, beta 4
LOC729164 hCG1732469
LRRC61 leucine rich repeat containing 61
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOX1 NADPH oxidase 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OXCT2 3-oxoacid CoA transferase 2
PCDH1 protocadherin 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PSG3 pregnancy specific beta-1-glycoprotein 3
PTRF polymerase I and transcript release factor
PYY peptide YY
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
REC8 REC8 meiotic recombination protein
RFPL1S RFPL1 antisense RNA 1
RHBDD3 rhomboid domain containing 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SARDH sarcosine dehydrogenase
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNCAIP synuclein, alpha interacting protein
SRRT serrate, RNA effector molecule
STK17A serine/threonine kinase 17a
TBXA2R thromboxane A2 receptor
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TLN1 talin 1
TMEM212 transmembrane protein 212
TOP3B topoisomerase (DNA) III beta
TP73-AS1 TP73 antisense RNA 1
TRAIP TRAF interacting protein
TSC22D4 TSC22 domain family, member 4
TTLL1 tubulin tyrosine ligase-like family member 1
UHRF1BP1L UHRF1 binding protein 1-like
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCX2 variable charge, X-linked 2
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNT2B wingless-type MMTV integration site family, member 2B
ZCCHC4 zinc finger, CCHC domain containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF350 zinc finger protein 350
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD17B abhydrolase domain containing 17B
ACSL4 acyl-CoA synthetase long-chain family member 4
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASAP1-IT1 ASAP1 intronic transcript 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP4 bone morphogenetic protein 4
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNK cyclin K
CES3 carboxylesterase 3
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
DUSP2 dual specificity phosphatase 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL4 ELOVL fatty acid elongase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
ESRP2 epithelial splicing regulatory protein 2
ETNK2 ethanolamine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189A2 family with sequence similarity 189, member A2
FANCC Fanconi anemia, complementation group C
FBXO2 F-box protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH2L G patch domain containing 2-like
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BI histone cluster 1, H2bi
HLA-DMA major histocompatibility complex, class II, DM alpha
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HP1BP3 heterochromatin protein 1, binding protein 3
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IQSEC2 IQ motif and Sec7 domain 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEL Kell blood group, metallo-endopeptidase
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
KIFAP3 kinesin-associated protein 3
LIG4 ligase IV, DNA, ATP-dependent
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MAGEB2 melanoma antigen family B2
MAPK12 mitogen-activated protein kinase 12
MATK megakaryocyte-associated tyrosine kinase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
OSMR oncostatin M receptor
PALM paralemmin
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPRS protein tyrosine phosphatase, receptor type, S
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIBC2 RIB43A domain with coiled-coils 2
RNF170 ring finger protein 170
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAYSD1 SAYSVFN motif domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH2B3 SH2B adaptor protein 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A6 solute carrier family 16, member 6
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SLN sarcolipin
SP1 Sp1 transcription factor
ST5 suppression of tumorigenicity 5
TCTN2 tectonic family member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLR2 toll-like receptor 2
TRIM25 tripartite motif containing 25
TRIM68 tripartite motif containing 68
TUBA3C tubulin, alpha 3c
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
VPS9D1 VPS9 domain containing 1
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF365 zinc finger protein 365
ZNF480 zinc finger protein 480
ZNF506 zinc finger protein 506
ZNF586 zinc finger protein 586