obesity Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_9970)
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Genes

333 genes associated with the disease obesity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACP1 acid phosphatase 1, soluble
ADAM17 ADAM metallopeptidase domain 17
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
ALPK1 alpha-kinase 1
ALPL alkaline phosphatase, liver/bone/kidney
ANKH ANKH inorganic pyrophosphate transport regulator
ANO3 anoctamin 3
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
ARL15 ADP-ribosylation factor-like 15
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATXN2 ataxin 2
BCDIN3D BCDIN3 domain containing
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BEGAIN brain-enriched guanylate kinase-associated
BHMT betaine--homocysteine S-methyltransferase
BMP2 bone morphogenetic protein 2
BSX brain-specific homeobox
C16ORF62 chromosome 16 open reading frame 62
CA10 carbonic anhydrase X
CAMK1D calcium/calmodulin-dependent protein kinase ID
CAPN10 calpain 10
CAPN5 calpain 5
CARTPT CART prepropeptide
CBS cystathionine-beta-synthase
CCDC85A coiled-coil domain containing 85A
CCKAR cholecystokinin A receptor
CD36 CD36 molecule (thrombospondin receptor)
CDC123 cell division cycle 123
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CETP cholesteryl ester transfer protein, plasma
CIDEA cell death-inducing DFFA-like effector a
CLOCK clock circadian regulator
CLPS colipase, pancreatic
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRH corticotropin releasing hormone
CRP C-reactive protein, pentraxin-related
CRTC1 CREB regulated transcription coactivator 1
CRY2 cryptochrome circadian clock 2
CTNNBL1 catenin, beta like 1
CTSS cathepsin S
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGKG diacylglycerol kinase, gamma 90kDa
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EDIL3 EGF-like repeats and discoidin I-like domains 3
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EML6 echinoderm microtubule associated protein like 6
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA6 EPH receptor A6
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETV5 ets variant 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAAH fatty acid amide hydrolase
FABP2 fatty acid binding protein 2, intestinal
FABP4 fatty acid binding protein 4, adipocyte
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FAIM2 Fas apoptotic inhibitory molecule 2
FAM71F1 family with sequence similarity 71, member F1
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FFAR1 free fatty acid receptor 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FOXC2 forkhead box C2
FOXP2 forkhead box P2
FTO fat mass and obesity associated
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
G6PC2 glucose-6-phosphatase, catalytic, 2
GAB2 GRB2-associated binding protein 2
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCK glucokinase (hexokinase 4)
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GPC6 glypican 6
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HFE hemochromatosis
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HOXB5 homeobox B5
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1B heat shock 70kDa protein 1B
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IDE insulin-degrading enzyme
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
INHBA inhibin, beta A
INS insulin
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
IVNS1ABP influenza virus NS1A binding protein
JADE2 jade family PHD finger 2
JAZF1 JAZF zinc finger 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD15 potassium channel tetramerization domain containing 15
KIF2B kinesin family member 2B
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LEPROTL1 leptin receptor overlapping transcript-like 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHFPL3 lipoma HMGIC fusion partner-like 3
LIN28B lin-28 homolog B (C. elegans)
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LRP5 low density lipoprotein receptor-related protein 5
LTA lymphotoxin alpha
LYPLAL1 lysophospholipase-like 1
MACROD2 MACRO domain containing 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MCHR2 melanin-concentrating hormone receptor 2
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGLL monoglyceride lipase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MKKS McKusick-Kaufman syndrome
MKL2 MKL/myocardin-like 2
MLN motilin
MLXIPL MLX interacting protein-like
MRPL9 mitochondrial ribosomal protein L9
MSRA methionine sulfoxide reductase A
MTCH2 mitochondrial carrier 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTMR9 myotubularin related protein 9
MTNR1B melatonin receptor 1B
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NAMPT nicotinamide phosphoribosyltransferase
NAP1L5 nucleosome assembly protein 1-like 5
NCAM2 neural cell adhesion molecule 2
NCR3 natural cytotoxicity triggering receptor 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEGR1 neuronal growth regulator 1
NMB neuromedin B
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPC1 Niemann-Pick disease, type C1
NPC1L1 NPC1-like 1
NPHP3 nephronophthisis 3 (adolescent)
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
OPRM1 opioid receptor, mu 1
PAX5 paired box 5
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE10A phosphodiesterase 10A
PER2 period circadian clock 2
PEX2 peroxisomal biogenesis factor 2
PFKP phosphofructokinase, platelet
PLCL1 phospholipase C-like 1
PLIN1 perilipin 1
PLIN4 perilipin 4
PLTP phospholipid transfer protein
PNMT phenylethanolamine N-methyltransferase
PNPLA3 patatin-like phospholipase domain containing 3
POMC proopiomelanocortin
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRDX6 peroxiredoxin 6
PRL prolactin
PRRC2A proline-rich coiled-coil 2A
PRSS23 protease, serine, 23
PTER phosphotriesterase related
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PYY peptide YY
PYY2 peptide YY, 2 (pseudogene)
RARB retinoic acid receptor, beta
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM6 RNA binding motif protein 6
RETN resistin
RFTN1 raftlin, lipid raft linker 1
RGS6 regulator of G-protein signaling 6
RNASE4 ribonuclease, RNase A family, 4
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RXRG retinoid X receptor, gamma
S1PR5 sphingosine-1-phosphate receptor 5
SAP30BP SAP30 binding protein
SCARB1 scavenger receptor class B, member 1
SDC3 syndecan 3
SDCCAG8 serologically defined colon cancer antigen 8
SEC16B SEC16 homolog B (S. cerevisiae)
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B1 SH2B adaptor protein 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3PXD2B SH3 and PX domains 2B
SIM1 single-minded family bHLH transcription factor 1
SIRT1 sirtuin 1
SKOR2 SKI family transcriptional corepressor 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLIT3 slit homolog 3 (Drosophila)
SNHG11 small nucleolar RNA host gene 11
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SOX6 SRY (sex determining region Y)-box 6
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SREBF1 sterol regulatory element binding transcription factor 1
SSTR2 somatostatin receptor 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBCA tubulin folding cofactor A
TCF20 transcription factor 20 (AR1)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP2 tight junction protein 2
TMEM101 transmembrane protein 101
TMEM108 transmembrane protein 108
TMEM18 transmembrane protein 18
TMEM38B transmembrane protein 38B
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRA2B transformer 2 beta homolog (Drosophila)
TRAP triiodothyronine receptor auxiliary protein
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN8 tetraspanin 8
TTC28 tetratricopeptide repeat domain 28
TUB tubby bipartite transcription factor
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USF1 upstream transcription factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VGLL3 vestigial-like family member 3
WDR36 WD repeat domain 36
WFS1 Wolfram syndrome 1 (wolframin)
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
ZNF483 zinc finger protein 483
ZPLD1 zona pellucida-like domain containing 1