obesity Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_9970)
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Genes

248 genes co-occuring with the disease obesity in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MC4R melanocortin 4 receptor 2.31276
LEP leptin 2.24364
INS insulin 1.85912
GHRL ghrelin/obestatin prepropeptide 1.78038
LEPR leptin receptor 1.75641
SIM1 single-minded family bHLH transcription factor 1 1.601
FTO fat mass and obesity associated 1.40789
PYY peptide YY 1.32934
MC3R melanocortin 3 receptor 1.28872
SH2B1 SH2B adaptor protein 1 1.19964
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.18109
PCSK1 proprotein convertase subtilisin/kexin type 1 1.16606
CRP C-reactive protein, pentraxin-related 1.1422
RETN resistin 1.14009
AGRP agouti related neuropeptide 1.12909
ADRB3 adrenoceptor beta 3 1.11856
NEGR1 neuronal growth regulator 1 1.05892
TBC1D14 TBC1 domain family, member 14 1.04377
INSIG2 insulin induced gene 2 1.02608
PTH parathyroid hormone 1.01934
AQP7 aquaporin 7 1.01132
MRAP2 melanocortin 2 receptor accessory protein 2 1.01132
PPY pancreatic polypeptide 0.949519
PPARG peroxisome proliferator-activated receptor gamma 0.945354
OSBPL11 oxysterol binding protein-like 11 0.930828
POMC proopiomelanocortin 0.925452
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.917199
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.874919
GIP gastric inhibitory polypeptide 0.863046
ALB albumin 0.847488
APMAP adipocyte plasma membrane associated protein 0.827409
CCK cholecystokinin 0.815924
SEC16B SEC16 homolog B (S. cerevisiae) 0.81059
KCTD15 potassium channel tetramerization domain containing 15 0.808129
GGT6 gamma-glutamyltransferase 6 0.801974
SHBG sex hormone-binding globulin 0.790081
GCG glucagon 0.785574
NAMPT nicotinamide phosphoribosyltransferase 0.770027
FABP2 fatty acid binding protein 2, intestinal 0.752085
HCRT hypocretin (orexin) neuropeptide precursor 0.73746
MCHR2 melanin-concentrating hormone receptor 2 0.733001
GNPDA2 glucosamine-6-phosphate deaminase 2 0.731786
LIPE lipase, hormone-sensitive 0.731381
TULP2 tubby like protein 2 0.71925
KIAA1462 KIAA1462 0.716425
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.692697
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.691094
LIPF lipase, gastric 0.677903
MTCH2 mitochondrial carrier 2 0.676706
IGF1 insulin-like growth factor 1 (somatomedin C) 0.66596
NPY neuropeptide Y 0.647348
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.639463
LPL lipoprotein lipase 0.637495
TNF tumor necrosis factor 0.633169
ADIPOR2 adiponectin receptor 2 0.629242
IGLV3-21 immunoglobulin lambda variable 3-21 0.626495
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.626103
CD79B CD79b molecule, immunoglobulin-associated beta 0.623359
IL6 interleukin 6 0.622575
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.622183
SREBF1 sterol regulatory element binding transcription factor 1 0.618268
NTS neurotensin 0.617486
FTL ferritin, light polypeptide 0.614356
FTH1 ferritin, heavy polypeptide 1 0.614356
CTNNBL1 catenin, beta like 1 0.608494
KISS1 KiSS-1 metastasis-suppressor 0.608104
GAST gastrin 0.597571
PRLHR prolactin releasing hormone receptor 0.588222
FAAH fatty acid amide hydrolase 0.582773
ALPPL2 alkaline phosphatase, placental-like 2 0.576939
ALPP alkaline phosphatase, placental 0.57655
ALPL alkaline phosphatase, liver/bone/kidney 0.575772
TTR transthyretin 0.572662
COG2 component of oligomeric golgi complex 2 0.572273
BBS4 Bardet-Biedl syndrome 4 0.571495
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.566443
ITLN1 intelectin 1 (galactofuranose binding) 0.557509
INSR insulin receptor 0.556344
LYPLAL1 lysophospholipase-like 1 0.549747
PACS1 phosphofurin acidic cluster sorting protein 1 0.545868
GNAS GNAS complex locus 0.518805
ARL6 ADP-ribosylation factor-like 6 0.509576
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.509576
DSE dermatan sulfate epimerase 0.509192
IL18 interleukin 18 0.504207
MTPAP mitochondrial poly(A) polymerase 0.503058
BBS1 Bardet-Biedl syndrome 1 0.498849
GGT1 gamma-glutamyltransferase 1 0.497321
IRS1 insulin receptor substrate 1 0.494266
CCL2 chemokine (C-C motif) ligand 2 0.490835
PNPLA3 patatin-like phospholipase domain containing 3 0.484364
GHRH growth hormone releasing hormone 0.483224
GLP1R glucagon-like peptide 1 receptor 0.482844
NPS neuropeptide S 0.482084
SEC24B SEC24 family member B 0.468819
BDNF brain-derived neurotrophic factor 0.468063
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.467306
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.463905
MLN motilin 0.457864
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 0.455601
PROKR1 prokineticin receptor 1 0.45447
CDCA8 cell division cycle associated 8 0.4443
FNDC5 fibronectin type III domain containing 5 0.443547
RBP4 retinol binding protein 4, plasma 0.439786
PLIN1 perilipin 1 0.437154
PNMA1 paraneoplastic Ma antigen 1 0.436402
CRTC1 CREB regulated transcription coactivator 1 0.436402
ETV5 ets variant 5 0.433772
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.431894
RPGRIP1L RPGRIP1-like 0.424014
STEAP4 STEAP family member 4 0.42214
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.421765
APOB apolipoprotein B 0.419892
BSX brain-specific homeobox 0.418019
GGTLC1 gamma-glutamyltransferase light chain 1 0.415398
NTF4 neurotrophin 4 0.411283
DOCK5 dedicator of cytokinesis 5 0.408292
SIRT1 sirtuin 1 0.407919
GGT2 gamma-glutamyltransferase 2 0.398962
PLG plasminogen 0.394491
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.388538
FAM120A family with sequence similarity 120A 0.385936
SP6 Sp6 transcription factor 0.380368
STXBP3 syntaxin binding protein 3 0.378885
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.372217
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.369997
GGT5 gamma-glutamyltransferase 5 0.369628
IRS2 insulin receptor substrate 2 0.365562
NPY2R neuropeptide Y receptor Y2 0.362978
NMUR2 neuromedin U receptor 2 0.359657
GANAB glucosidase, alpha; neutral AB 0.358183
SPON2 spondin 2, extracellular matrix protein 0.355972
PLIN5 perilipin 5 0.354131
GLYAT glycine-N-acyltransferase 0.353027
AHSG alpha-2-HS-glycoprotein 0.351187
PCTP phosphatidylcholine transfer protein 0.349349
ARL13B ADP-ribosylation factor-like 13B 0.346777
FABP4 fatty acid binding protein 4, adipocyte 0.344207
CNR1 cannabinoid receptor 1 (brain) 0.343473
GGT7 gamma-glutamyltransferase 7 0.343106
TMEM18 transmembrane protein 18 0.341639
GPS2 G protein pathway suppressor 2 0.337242
GLUD1 glutamate dehydrogenase 1 0.333218
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.327375
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.325552
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.325187
CHD8 chromodomain helicase DNA binding protein 8 0.325187
DGKZ diacylglycerol kinase, zeta 0.324823
ADIPOR1 adiponectin receptor 1 0.322637
ALMS1 Alstrom syndrome protein 1 0.320454
GCK glucokinase (hexokinase 4) 0.319726
GPS1 G protein pathway suppressor 1 0.317182
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.315366
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.315366
ZNF148 zinc finger protein 148 0.309928
ADIPOQ adiponectin, C1Q and collagen domain containing 0.309566
EXOSC4 exosome component 4 0.307033
PRLH prolactin releasing hormone 0.305948
GLS2 glutaminase 2 (liver, mitochondrial) 0.305587
ERH enhancer of rudimentary homolog (Drosophila) 0.304864
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.304503
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.301976
IRS4 insulin receptor substrate 4 0.301615
PTER phosphotriesterase related 0.300173
PRAMEF12 PRAME family member 12 0.299092
OSBP oxysterol binding protein 0.295851
RAB11A RAB11A, member RAS oncogene family 0.291898
MC5R melanocortin 5 receptor 0.288668
NPC1 Niemann-Pick disease, type C1 0.286519
KIF1B kinesin family member 1B 0.28151
CD36 CD36 molecule (thrombospondin receptor) 0.272953
RTN1 reticulon 1 0.272597
AKTIP AKT interacting protein 0.268687
HOXB5 homeobox B5 0.268687
FOXJ2 forkhead box J2 0.268687
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.266558
LSM1 LSM1, U6 small nuclear RNA associated 0.26514
ENSA endosulfine alpha 0.25877
ITGAD integrin, alpha D 0.258417
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.254183
PNPLA2 patatin-like phospholipase domain containing 2 0.24996
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.248203
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.247501
HADH hydroxyacyl-CoA dehydrogenase 0.247501
PRKCH protein kinase C, eta 0.24715
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.244696
IL33 interleukin 33 0.244345
MT1E metallothionein 1E 0.242945
SDC3 syndecan 3 0.23666
NRG1 neuregulin 1 0.235964
CCKAR cholecystokinin A receptor 0.235268
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.234573
ANGPTL4 angiopoietin-like 4 0.234225
NRXN3 neurexin 3 0.233183
ADRA2B adrenoceptor alpha 2B 0.230755
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.230755
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.230755
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.226952
TRAPPC9 trafficking protein particle complex 9 0.223853
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.223165
BBS12 Bardet-Biedl syndrome 12 0.22145
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.220424
ACACB acetyl-CoA carboxylase beta 0.218374
BBS10 Bardet-Biedl syndrome 10 0.218034
PRRC2A proline-rich coiled-coil 2A 0.217693
LRRC38 leucine rich repeat containing 38 0.217352
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.216672
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.214297
MIR130B microRNA 130b 0.213959
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.212271
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.211597
NRIP1 nuclear receptor interacting protein 1 0.210589
APOA1 apolipoprotein A-I 0.208245
GANC glucosidase, alpha; neutral C 0.203604
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.201962
FAIM2 Fas apoptotic inhibitory molecule 2 0.200331
BRD2 bromodomain containing 2 0.198709
APOA2 apolipoprotein A-II 0.198064
UBA1 ubiquitin-like modifier activating enzyme 1 0.198064
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.197742
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.197099
NNAT neuronatin 0.194865
TF transferrin 0.190168
ICK intestinal cell (MAK-like) kinase 0.188938
LCT lactase 0.188022
MCHR1 melanin-concentrating hormone receptor 1 0.187113
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.185016
F2 coagulation factor II (thrombin) 0.185016
AQP9 aquaporin 9 0.183835
DPP4 dipeptidyl-peptidase 4 0.183248
MT1A metallothionein 1A 0.178403
TMEM245 transmembrane protein 245 0.172038
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.170544
OLFM4 olfactomedin 4 0.16933
DMRTA1 DMRT-like family A1 0.169091
GIF gastric intrinsic factor (vitamin B synthesis) 0.169091
ADRB2 adrenoceptor beta 2, surface 0.167682
ADCY3 adenylate cyclase 3 0.167682
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.167452
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.165655
PNLIP pancreatic lipase 0.164571
SOCS3 suppressor of cytokine signaling 3 0.163317
SST somatostatin 0.162908
GSR glutathione reductase 0.162109
SDF4 stromal cell derived factor 4 0.161331
SNAP25 synaptosomal-associated protein, 25kDa 0.160948
PEX10 peroxisomal biogenesis factor 10 0.158266
CD40LG CD40 ligand 0.157929