nucleotide-excision repair Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). (Gene Ontology, GO_0006289)
External Link http://amigo.geneontology.org/amigo/term/GO:0006289
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Genes

75 genes participating in the nucleotide-excision repair biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATXN3 ataxin 3
BRCA2 breast cancer 2, early onset
CCNH cyclin H
CDK7 cyclin-dependent kinase 7
CETN2 centrin, EF-hand protein, 2
DCLRE1A DNA cross-link repair 1A
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
FAN1 FANCD2/FANCI-associated nuclease 1
FANCC Fanconi anemia, complementation group C
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF2H5 general transcription factor IIH, polypeptide 5
HMGN1 high mobility group nucleosome binding domain 1
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
LIG1 ligase I, DNA, ATP-dependent
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PCNA proliferating cell nuclear antigen
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLL polymerase (DNA directed), lambda
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPA4 replication protein A4, 30kDa
SIRT1 sirtuin 1
SLC30A9 solute carrier family 30 (zinc transporter), member 9
SLX4 SLX4 structure-specific endonuclease subunit
TCEA1 transcription elongation factor A (SII), 1
TP53 tumor protein p53
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UVSSA UV-stimulated scaffold protein A
XAB2 XPA binding protein 2
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C