nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. (Gene Ontology, GO_0035872)
External Link http://amigo.geneontology.org/amigo/term/GO:0035872
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Genes

45 genes participating in the nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AIM2 absent in melanoma 2
APP amyloid beta (A4) precursor protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
CARD9 caspase recruitment domain family, member 9
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CHUK conserved helix-loop-helix ubiquitous kinase
CYLD cylindromatosis (turban tumor syndrome)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
ITCH itchy E3 ubiquitin protein ligase
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MEFV Mediterranean fever
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
OTULIN OTU deubiquitinase with linear linkage specificity
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PANX1 pannexin 1
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PYCARD PYD and CARD domain containing
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIPK2 receptor-interacting serine-threonine kinase 2
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TXN thioredoxin
TXNIP thioredoxin interacting protein
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N