nuclear speck Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. (Gene Ontology, GO_0016607)
External Link http://amigo.geneontology.org/amigo/term/GO:0016607
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Genes

173 proteins localized to the nuclear speck cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
AFF2 AF4/FMR2 family, member 2
AKAP17A A kinase (PRKA) anchor protein 17A
ALKBH5 AlkB family member 5, RNA demethylase
ALYREF Aly/REF export factor
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
ATXN2L ataxin 2-like
BASP1 brain abundant, membrane attached signal protein 1
CASC3 cancer susceptibility candidate 3
CBX4 chromobox homolog 4
CBY1 chibby homolog 1 (Drosophila)
CCNL1 cyclin L1
CCNL2 cyclin L2
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CDC5L cell division cycle 5-like
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CHTOP chromatin target of PRMT1
CIR1 corepressor interacting with RBPJ, 1
CLK2 CDC-like kinase 2
CLK3 CDC-like kinase 3
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSNK1A1 casein kinase 1, alpha 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CWC22 CWC22 spliceosome-associated protein
CXXC1 CXXC finger protein 1
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DGKQ diacylglycerol kinase, theta 110kDa
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EAF1 ELL associated factor 1
EAF2 ELL associated factor 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELL elongation factor RNA polymerase II
EP400 E1A binding protein p400
FAM206A family with sequence similarity 206, member A
FAM76B family with sequence similarity 76, member B
FTO fat mass and obesity associated
FYTTD1 forty-two-three domain containing 1
GATAD2A GATA zinc finger domain containing 2A
GATAD2B GATA zinc finger domain containing 2B
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GLIS2 GLIS family zinc finger 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK1 homeodomain interacting protein kinase 1
IFI16 interferon, gamma-inducible protein 16
KMT2E lysine (K)-specific methyltransferase 2E
LMNA lamin A/C
LUC7L2 LUC7-like 2 (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MBD1 methyl-CpG binding domain protein 1
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MEOX2 mesenchyme homeobox 2
METTL3 methyltransferase like 3
NEK6 NIMA-related kinase 6
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NONO non-POU domain containing, octamer-binding
NRIP1 nuclear receptor interacting protein 1
NSRP1 nuclear speckle splicing regulatory protein 1
NXF1 nuclear RNA export factor 1
NXT1 nuclear transport factor 2-like export factor 1
OGG1 8-oxoguanine DNA glycosylase
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PHF5A PHD finger protein 5A
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLRG1 pleiotropic regulator 1
PNISR PNN-interacting serine/arginine-rich protein
PNN pinin, desmosome associated protein
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POU4F2 POU class 4 homeobox 2
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPIH peptidylprolyl isomerase H (cyclophilin H)
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R8 protein phosphatase 1, regulatory subunit 8
PQBP1 polyglutamine binding protein 1
PRPF18 pre-mRNA processing factor 18
PRPF19 pre-mRNA processing factor 19
PRPF3 pre-mRNA processing factor 3
PRPF31 pre-mRNA processing factor 31
PRPF4 pre-mRNA processing factor 4
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
PRPF6 pre-mRNA processing factor 6
PRPF8 pre-mRNA processing factor 8
PSKH1 protein serine kinase H1
PSME4 proteasome (prosome, macropain) activator subunit 4
PSPC1 paraspeckle component 1
PYHIN1 pyrin and HIN domain family, member 1
RBM11 RNA binding motif protein 11
RBM25 RNA binding motif protein 25
RBM27 RNA binding motif protein 27
RBM39 RNA binding motif protein 39
RBM4 RNA binding motif protein 4
RBM8A RNA binding motif protein 8A
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RING1 ring finger protein 1
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNPS1 RNA binding protein S1, serine-rich domain
RREB1 ras responsive element binding protein 1
RSRC1 arginine/serine-rich coiled-coil 1
SAP18 Sin3A-associated protein, 18kDa
SARNP SAP domain containing ribonucleoprotein
SART3 squamous cell carcinoma antigen recognized by T cells 3
SETD1A SET domain containing 1A
SETD1B SET domain containing 1B
SF3A3 splicing factor 3a, subunit 3, 60kDa
SF3B1 splicing factor 3b, subunit 1, 155kDa
SLU7 SLU7 splicing factor homolog (S. cerevisiae)
SMNDC1 survival motor neuron domain containing 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SON SON DNA binding protein
SPOP speckle-type POZ protein
SPRTN SprT-like N-terminal domain
SRP54 signal recognition particle 54kDa
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF10 serine/arginine-rich splicing factor 10
SRSF2 serine/arginine-rich splicing factor 2
SRSF4 serine/arginine-rich splicing factor 4
SRSF5 serine/arginine-rich splicing factor 5
SRSF6 serine/arginine-rich splicing factor 6
SRY sex determining region Y
SUMO1 small ubiquitin-like modifier 1
TARDBP TAR DNA binding protein
TENM1 teneurin transmembrane protein 1
TFIP11 tuftelin interacting protein 11
THAP7 THAP domain containing 7
THOC1 THO complex 1
THOC2 THO complex 2
THOC3 THO complex 3
THOC5 THO complex 5
THOC6 THO complex 6
THOC7 THO complex 7
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TOE1 target of EGR1, member 1 (nuclear)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM22 tripartite motif containing 22
TRIM69 tripartite motif containing 69
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
U2AF1L4 U2 small nuclear RNA auxiliary factor 1-like 4
U2AF2 U2 small nuclear RNA auxiliary factor 2
WAC WW domain containing adaptor with coiled-coil
WBP11 WW domain binding protein 11
WBP4 WW domain binding protein 4
WT1 Wilms tumor 1
WTAP Wilms tumor 1 associated protein
YLPM1 YLP motif containing 1
ZBTB16 zinc finger and BTB domain containing 16
ZC3H14 zinc finger CCCH-type containing 14
ZCCHC12 zinc finger, CCHC domain containing 12
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF638 zinc finger protein 638
ZNF830 zinc finger protein 830