nuclear lamina Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. (Gene Ontology, GO_0005652)
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8 proteins localized to the nuclear lamina cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
LMNA lamin A/C 0.663342
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.663342
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.663342
LMNB1 lamin B1 0.237908
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.237908
NARF nuclear prelamin A recognition factor 0.237908
LMNB2 lamin B2 0.03318
EIF6 eukaryotic translation initiation factor 6 0.03318