novobiocin-499 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the novobiocin-499 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
AEN apoptosis enhancing nuclease
ALX3 ALX homeobox 3
ATXN2L ataxin 2-like
BACE1 beta-site APP-cleaving enzyme 1
BCL2L14 BCL2-like 14 (apoptosis facilitator)
CAV3 caveolin 3
CCDC176 coiled-coil domain containing 176
CD44 CD44 molecule (Indian blood group)
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP57 centrosomal protein 57kDa
CER1 cerberus 1, DAN family BMP antagonist
CFAP70 cilia and flagella associated protein 70
CHERP calcium homeostasis endoplasmic reticulum protein
CTTN cortactin
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYTH4 cytohesin 4
DAAM1 dishevelled associated activator of morphogenesis 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DIXDC1 DIX domain containing 1
DNASE1L2 deoxyribonuclease I-like 2
DPEP1 dipeptidase 1 (renal)
ECE2 endothelin converting enzyme 2
EPHB1 EPH receptor B1
EPOR erythropoietin receptor
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM134B family with sequence similarity 134, member B
FAM188A family with sequence similarity 188, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GAGE3 G antigen 3
GAS8-AS1 GAS8 antisense RNA 1
GMDS GDP-mannose 4,6-dehydratase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRIP2 glutamate receptor interacting protein 2
GSK3A glycogen synthase kinase 3 alpha
GYPB glycophorin B (MNS blood group)
HBBP1 hemoglobin, beta pseudogene 1
HLA-F major histocompatibility complex, class I, F
HMGA1 high mobility group AT-hook 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL13 interleukin 13
IRS4 insulin receptor substrate 4
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KIAA1614 KIAA1614
KLK8 kallikrein-related peptidase 8
KRT75 keratin 75, type II
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LGMN legumain
LOC440895 two pore channel 3 pseudogene
LOC647070 uncharacterized LOC647070
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRC2 mannose receptor, C type 2
MYL10 myosin, light chain 10, regulatory
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NDRG2 NDRG family member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP2 neuropilin 2
PADI1 peptidyl arginine deiminase, type I
PCSK6 proprotein convertase subtilisin/kexin type 6
PECR peroxisomal trans-2-enoyl-CoA reductase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIP prolactin-induced protein
PLXNA2 plexin A2
PRB1 proline-rich protein BstNI subfamily 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKD3 protein kinase D3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBM5 RNA binding motif protein 5
RGSL1 regulator of G-protein signaling like 1
RHAG Rh-associated glycoprotein
RHOD ras homolog family member D
RORC RAR-related orphan receptor C
RPL10 ribosomal protein L10
SH2D1A SH2 domain containing 1A
SH3GL3 SH3-domain GRB2-like 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRSF1 serine/arginine-rich splicing factor 1
STK19 serine/threonine kinase 19
STX2 syntaxin 2
TGM3 transglutaminase 3
TM4SF4 transmembrane 4 L six family member 4
TMEM177 transmembrane protein 177
TRIM10 tripartite motif containing 10
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPYL2 TSPY-like 2
UBA6 ubiquitin-like modifier activating enzyme 6
USF2 upstream transcription factor 2, c-fos interacting
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ADAMTSL4 ADAMTS-like 4
ADIRF adipogenesis regulatory factor
ANXA6 annexin A6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHMT betaine--homocysteine S-methyltransferase
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CBX7 chromobox homolog 7
CENPE centromere protein E, 312kDa
CFAP45 cilia and flagella associated protein 45
CFAP69 cilia and flagella associated protein 69
CLCA1 chloride channel accessory 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN15 claudin 15
CNTD2 cyclin N-terminal domain containing 2
CRYAA crystallin, alpha A
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCPS decapping enzyme, scavenger
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNASE1L3 deoxyribonuclease I-like 3
DRP2 dystrophin related protein 2
DTX2 deltex 2, E3 ubiquitin ligase
EGLN3 egl-9 family hypoxia-inducible factor 3
ELOVL4 ELOVL fatty acid elongase 4
ERCC2 excision repair cross-complementation group 2
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM153A family with sequence similarity 153, member A
FAM192A family with sequence similarity 192, member A
FANCF Fanconi anemia, complementation group F
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
FTCD formimidoyltransferase cyclodeaminase
FXYD6 FXYD domain containing ion transport regulator 6
G6PC2 glucose-6-phosphatase, catalytic, 2
GALR3 galanin receptor 3
GRWD1 glutamate-rich WD repeat containing 1
HIRA histone cell cycle regulator
HPGDS hematopoietic prostaglandin D synthase
IRF9 interferon regulatory factor 9
JOSD1 Josephin domain containing 1
KIF20B kinesin family member 20B
KIFAP3 kinesin-associated protein 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LGALS9 lectin, galactoside-binding, soluble, 9
LHX6 LIM homeobox 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MARK1 MAP/microtubule affinity-regulating kinase 1
MATK megakaryocyte-associated tyrosine kinase
MC3R melanocortin 3 receptor
MON1B MON1 secretory trafficking family member B
MTERF3 mitochondrial transcription termination factor 3
MTERF4 mitochondrial transcription termination factor 4
NCAPH non-SMC condensin I complex, subunit H
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NRSN2 neurensin 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB3 protocadherin beta 3
PHOX2A paired-like homeobox 2a
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PNMA3 paraneoplastic Ma antigen 3
PODNL1 podocan-like 1
PON3 paraoxonase 3
RAD54L RAD54-like (S. cerevisiae)
RAI14 retinoic acid induced 14
RASL10A RAS-like, family 10, member A
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SIL1 SIL1 nucleotide exchange factor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNPO synaptopodin
SYT2 synaptotagmin II
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARBP1 TAR (HIV-1) RNA binding protein 1
TEX13B testis expressed 13B
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM127 transmembrane protein 127
TMEM185B transmembrane protein 185B
TNS4 tensin 4
TPST2 tyrosylprotein sulfotransferase 2
TRAPPC12 trafficking protein particle complex 12
TREML2 triggering receptor expressed on myeloid cells-like 2
TSHZ2 teashirt zinc finger homeobox 2
TSNAXIP1 translin-associated factor X interacting protein 1
USP20 ubiquitin specific peptidase 20
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)