novobiocin-4392 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the novobiocin-4392 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ANGPT4 angiopoietin 4
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ATP10B ATPase, class V, type 10B
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAHD1 bromo adjacent homology domain containing 1
C6 complement component 6
CADM4 cell adhesion molecule 4
CC2D1A coiled-coil and C2 domain containing 1A
CEP135 centrosomal protein 135kDa
CEP41 centrosomal protein 41kDa
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLTC clathrin, heavy chain (Hc)
COL6A3 collagen, type VI, alpha 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPLX2 complexin 2
CSF1 colony stimulating factor 1 (macrophage)
CST4 cystatin S
CTNS cystinosin, lysosomal cystine transporter
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DEPDC5 DEP domain containing 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EFR3B EFR3 homolog B (S. cerevisiae)
ERO1LB ERO1-like beta (S. cerevisiae)
EXOSC1 exosome component 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAIM2 Fas apoptotic inhibitory molecule 2
FAM105A family with sequence similarity 105, member A
FRMD1 FERM domain containing 1
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GJC2 gap junction protein, gamma 2, 47kDa
GPER1 G protein-coupled estrogen receptor 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIP2 glutamate receptor interacting protein 2
GSAP gamma-secretase activating protein
GYG2 glycogenin 2
HDAC6 histone deacetylase 6
HEXIM1 hexamethylene bis-acetamide inducible 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HRH1 histamine receptor H1
IFNA14 interferon, alpha 14
IQCK IQ motif containing K
IRF4 interferon regulatory factor 4
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KIF25 kinesin family member 25
LAMP1 lysosomal-associated membrane protein 1
LIMK1 LIM domain kinase 1
LOC390998 ribosomal protein L10 pseudogene
LSP1 lymphocyte-specific protein 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MROH7 maestro heat-like repeat family member 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT3 metallothionein 3
MYO15A myosin XVA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NUP188 nucleoporin 188kDa
PARP3 poly (ADP-ribose) polymerase family, member 3
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PQLC2 PQ loop repeat containing 2
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
RARA retinoic acid receptor, alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RIMS1 regulating synaptic membrane exocytosis 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SATB1 SATB homeobox 1
SETBP1 SET binding protein 1
SIRT4 sirtuin 4
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SRSF7 serine/arginine-rich splicing factor 7
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNDIG1 synapse differentiation inducing 1
TCF12 transcription factor 12
TECPR2 tectonin beta-propeller repeat containing 2
TEX13B testis expressed 13B
TRIP11 thyroid hormone receptor interactor 11
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTC39A tetratricopeptide repeat domain 39A
TUBB7P tubulin, beta 7, pseudogene
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZFP64 ZFP64 zinc finger protein
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAP2 ArfGAP with dual PH domains 2
ALOX15 arachidonate 15-lipoxygenase
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC4 armadillo repeat containing 4
ASPHD1 aspartate beta-hydroxylase domain containing 1
BST2 bone marrow stromal cell antigen 2
BTF3P11 basic transcription factor 3 pseudogene 11
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C1ORF54 chromosome 1 open reading frame 54
C9ORF9 chromosome 9 open reading frame 9
CCDC121 coiled-coil domain containing 121
CCDC94 coiled-coil domain containing 94
CCP110 centriolar coiled coil protein 110kDa
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CNTNAP1 contactin associated protein 1
CTSF cathepsin F
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETAA1 Ewing tumor-associated antigen 1
FGL1 fibrinogen-like 1
FILIP1L filamin A interacting protein 1-like
FKBP5 FK506 binding protein 5
GPC3 glypican 3
GPR157 G protein-coupled receptor 157
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2BO histone cluster 1, H2bo
HOXC5 homeobox C5
HOXC8 homeobox C8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYAL3 hyaluronoglucosaminidase 3
HYI hydroxypyruvate isomerase (putative)
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INO80D INO80 complex subunit D
IRF9 interferon regulatory factor 9
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCTD20 potassium channel tetramerization domain containing 20
KPNA5 karyopherin alpha 5 (importin alpha 6)
LMNB1 lamin B1
LRRC37A2 leucine rich repeat containing 37, member A2
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYPLA2P1 lysophospholipase II pseudogene 1
METTL16 methyltransferase like 16
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MX2 MX dynamin-like GTPase 2
MXD3 MAX dimerization protein 3
MYO1F myosin IF
NEK11 NIMA-related kinase 11
NEUROD1 neuronal differentiation 1
NT5DC3 5'-nucleotidase domain containing 3
NXPH4 neurexophilin 4
OSMR oncostatin M receptor
OVGP1 oviductal glycoprotein 1, 120kDa
PDE12 phosphodiesterase 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POM121 POM121 transmembrane nucleoporin
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPAP1 RNA polymerase II associated protein 1
RUSC2 RUN and SH3 domain containing 2
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC22A14 solute carrier family 22, member 14
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SREK1IP1 SREK1-interacting protein 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBL1Y transducin (beta)-like 1, Y-linked
TCEAL2 transcription elongation factor A (SII)-like 2
TMEM209 transmembrane protein 209
TPSG1 tryptase gamma 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC22D4 TSC22 domain family, member 4
TSNAXIP1 translin-associated factor X interacting protein 1
VEZT vezatin, adherens junctions transmembrane protein
VIM vimentin
WDR33 WD repeat domain 33
WDR91 WD repeat domain 91
WLS wntless Wnt ligand secretion mediator
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZBTB48 zinc finger and BTB domain containing 48
ZNF324 zinc finger protein 324
ZNF76 zinc finger protein 76
ZNF816 zinc finger protein 816