nortriptyline-7300 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nortriptyline-7300 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADAM8 ADAM metallopeptidase domain 8
AMIGO2 adhesion molecule with Ig-like domain 2
APOC4 apolipoprotein C-IV
ARC activity-regulated cytoskeleton-associated protein
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
C1ORF54 chromosome 1 open reading frame 54
C6ORF10 chromosome 6 open reading frame 10
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL8A1 collagen, type VIII, alpha 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CTIF CBP80/20-dependent translation initiation factor
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDN dendrin
DHODH dihydroorotate dehydrogenase (quinone)
DRP2 dystrophin related protein 2
DUSP8 dual specificity phosphatase 8
EPHB2 EPH receptor B2
EPS8L1 EPS8-like 1
FAM63B family with sequence similarity 63, member B
FAM69A family with sequence similarity 69, member A
FLJ11292
FOXO1 forkhead box O1
FYB FYN binding protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GPR68 G protein-coupled receptor 68
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC11 histone deacetylase 11
IFT140 intraflagellar transport 140
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUND jun D proto-oncogene
KLHL18 kelch-like family member 18
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LOC257152 uncharacterized LOC257152
LOC399491
LOXL3 lysyl oxidase-like 3
LRP1 low density lipoprotein receptor-related protein 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARS methionyl-tRNA synthetase
MED25 mediator complex subunit 25
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MVK mevalonate kinase
MYRF myelin regulatory factor
NEK11 NIMA-related kinase 11
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NKX6-1 NK6 homeobox 1
NUP62CL nucleoporin 62kDa C-terminal like
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PASK PAS domain containing serine/threonine kinase
PAX3 paired box 3
PCDHGA10 protocadherin gamma subfamily A, 10
PILRA paired immunoglobin-like type 2 receptor alpha
PLAG1 pleiomorphic adenoma gene 1
PLCH2 phospholipase C, eta 2
PLXNA3 plexin A3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POU5F1B POU class 5 homeobox 1B
PRKCA protein kinase C, alpha
PRO2964 uncharacterized protein PRO2964
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB31 RAB31, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS10 regulator of G-protein signaling 10
RNF6 ring finger protein (C3H2C3 type) 6
RS1 retinoschisin 1
RTEL1 regulator of telomere elongation helicase 1
RUNX1-IT1 RUNX1 intronic transcript 1
RUSC2 RUN and SH3 domain containing 2
SBNO1 strawberry notch homolog 1 (Drosophila)
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STAC SH3 and cysteine rich domain
TGFB2 transforming growth factor, beta 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE4 transducin-like enhancer of split 4
TLN2 talin 2
TMEM176A transmembrane protein 176A
TMEM63A transmembrane protein 63A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TTC9 tetratricopeptide repeat domain 9
TTLL7 tubulin tyrosine ligase-like family member 7
VCAM1 vascular cell adhesion molecule 1
VWA5A von Willebrand factor A domain containing 5A
WDR62 WD repeat domain 62
ZNF280A zinc finger protein 280A
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADGRA3 adhesion G protein-coupled receptor A3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP11A Rho GTPase activating protein 11A
ASTE1 asteroid homolog 1 (Drosophila)
BBS10 Bardet-Biedl syndrome 10
BCL2A1 BCL2-related protein A1
BIK BCL2-interacting killer (apoptosis-inducing)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSPRY B-box and SPRY domain containing
C10ORF88 chromosome 10 open reading frame 88
C17ORF62 chromosome 17 open reading frame 62
C19ORF40 chromosome 19 open reading frame 40
C1ORF109 chromosome 1 open reading frame 109
C6ORF47 chromosome 6 open reading frame 47
CASP8AP2 caspase 8 associated protein 2
CCDC94 coiled-coil domain containing 94
CCP110 centriolar coiled coil protein 110kDa
CCS copper chaperone for superoxide dismutase
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFAP44 cilia and flagella associated protein 44
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRELD1 cysteine-rich with EGF-like domains 1
CST6 cystatin E/M
CUL9 cullin 9
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCLRE1B DNA cross-link repair 1B
DHRS11 dehydrogenase/reductase (SDR family) member 11
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLK1 delta-like 1 homolog (Drosophila)
ELOVL4 ELOVL fatty acid elongase 4
EML4 echinoderm microtubule associated protein like 4
F3 coagulation factor III (thromboplastin, tissue factor)
FAM50B family with sequence similarity 50, member B
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GDAP1 ganglioside induced differentiation associated protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRAMD1B GRAM domain containing 1B
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HAS2 hyaluronan synthase 2
HDAC4 histone deacetylase 4
HIST1H1D histone cluster 1, H1d
HPS6 Hermansky-Pudlak syndrome 6
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IGFLR1 IGF-like family receptor 1
KIAA1462 KIAA1462
KIF18A kinesin family member 18A
KISS1 KiSS-1 metastasis-suppressor
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MNX1 motor neuron and pancreas homeobox 1
MON1B MON1 secretory trafficking family member B
MRPL52 mitochondrial ribosomal protein L52
MRPS27 mitochondrial ribosomal protein S27
MTERF1 mitochondrial transcription termination factor 1
MUTYH mutY homolog
NCS1 neuronal calcium sensor 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NHLRC2 NHL repeat containing 2
NME5 NME/NM23 family member 5
NUBPL nucleotide binding protein-like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PLAC1 placenta-specific 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
RAB23 RAB23, member RAS oncogene family
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
S100A3 S100 calcium binding protein A3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETBP1 SET binding protein 1
SGMS1 sphingomyelin synthase 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPAG16 sperm associated antigen 16
STAR steroidogenic acute regulatory protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TCTN1 tectonic family member 1
TMEM209 transmembrane protein 209
TNRC6B trinucleotide repeat containing 6B
TRAF5 TNF receptor-associated factor 5
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UEVLD UEV and lactate/malate dehyrogenase domains
UNC13B unc-13 homolog B (C. elegans)
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
USP8 ubiquitin specific peptidase 8
XK X-linked Kx blood group
ZC3H12A zinc finger CCCH-type containing 12A
ZNF212 zinc finger protein 212
ZNF230 zinc finger protein 230
ZNF816 zinc finger protein 816
ZNF84 zinc finger protein 84