norfloxacin-7283 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the norfloxacin-7283 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
AK1 adenylate kinase 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMBRA1 autophagy/beclin-1 regulator 1
APOC4 apolipoprotein C-IV
ATXN3 ataxin 3
BDKRB1 bradykinin receptor B1
BMP8A bone morphogenetic protein 8a
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCR7 chemokine (C-C motif) receptor 7
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEMP1 cementum protein 1
CHGA chromogranin A
CLEC10A C-type lectin domain family 10, member A
COL14A1 collagen, type XIV, alpha 1
CSHL1 chorionic somatomammotropin hormone-like 1
CTAG2 cancer/testis antigen 2
CXCR2 chemokine (C-X-C motif) receptor 2
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DCLK2 doublecortin-like kinase 2
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
ECE1 endothelin converting enzyme 1
EGOT eosinophil granule ontogeny transcript (non-protein coding)
EMX1 empty spiracles homeobox 1
EPAS1 endothelial PAS domain protein 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FRMPD1 FERM and PDZ domain containing 1
HDLBP high density lipoprotein binding protein
HIST1H3B histone cluster 1, H3b
HIST1H3G histone cluster 1, H3g
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IBSP integrin-binding sialoprotein
IFIH1 interferon induced with helicase C domain 1
INS insulin
ITK IL2-inducible T-cell kinase
JUND jun D proto-oncogene
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLHL22 kelch-like family member 22
KRT12 keratin 12, type I
KRT32 keratin 32, type I
KYNU kynureninase
LAMA4 laminin, alpha 4
LPAR4 lysophosphatidic acid receptor 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MTMR7 myotubularin related protein 7
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NPPB natriuretic peptide B
NRG1 neuregulin 1
ONECUT2 one cut homeobox 2
OSBP2 oxysterol binding protein 2
PBOV1 prostate and breast cancer overexpressed 1
PCDHB17P protocadherin beta 17 pseudogene
PKP3 plakophilin 3
PLCH1 phospholipase C, eta 1
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PTEN phosphatase and tensin homolog
PTGER3 prostaglandin E receptor 3 (subtype EP3)
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS14 regulator of G-protein signaling 14
RUNX1-IT1 RUNX1 intronic transcript 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPAG8 sperm associated antigen 8
SPATA1 spermatogenesis associated 1
SPRR1A small proline-rich protein 1A
SSX1 synovial sarcoma, X breakpoint 1
TEF thyrotrophic embryonic factor
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TJP3 tight junction protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TTLL1 tubulin tyrosine ligase-like family member 1
TUSC3 tumor suppressor candidate 3
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF407 zinc finger protein 407
ZNF440 zinc finger protein 440
ZNF571 zinc finger protein 571
ZNF710 zinc finger protein 710
ZNF93 zinc finger protein 93
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF1 adhesion G protein-coupled receptor F1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APH1A APH1A gamma secretase subunit
B3GNT1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS3 breast carcinoma amplified sequence 3
BOLA1 bolA family member 1
C9ORF91 chromosome 9 open reading frame 91
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CTSO cathepsin O
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DPYD dihydropyrimidine dehydrogenase
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERCC2 excision repair cross-complementation group 2
FPGS folylpolyglutamate synthase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCC1 GRIP and coiled-coil domain containing 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPALPP1 GPALPP motifs containing 1
GPS2 G protein pathway suppressor 2
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIRA histone cell cycle regulator
HIRIP3 HIRA interacting protein 3
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IFT22 intraflagellar transport 22
IRF6 interferon regulatory factor 6
KATNBL1 katanin p80 subunit B-like 1
KIAA1462 KIAA1462
LIN37 lin-37 DREAM MuvB core complex component
LRRC37A3 leucine rich repeat containing 37, member A3
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MNS1 meiosis-specific nuclear structural 1
MORC3 MORC family CW-type zinc finger 3
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
NOV nephroblastoma overexpressed
OPLAH 5-oxoprolinase (ATP-hydrolysing)
P3H2 prolyl 3-hydroxylase 2
PALMD palmdelphin
PEX13 peroxisomal biogenesis factor 13
PHACTR4 phosphatase and actin regulator 4
PHKG2 phosphorylase kinase, gamma 2 (testis)
PKN1 protein kinase N1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PROSER1 proline and serine rich 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RBL1 retinoblastoma-like 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS19 regulator of G-protein signaling 19
RNF44 ring finger protein 44
SCRIB scribbled planar cell polarity protein
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERINC5 serine incorporator 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
STAR steroidogenic acute regulatory protein
STARD13 StAR-related lipid transfer (START) domain containing 13
STBD1 starch binding domain 1
STX18 syntaxin 18
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D17 TBC1 domain family, member 17
TCTN1 tectonic family member 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
THBS3 thrombospondin 3
TMEM132A transmembrane protein 132A
TMEM2 transmembrane protein 2
TRIM16 tripartite motif containing 16
TRIM58 tripartite motif containing 58
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR76 WD repeat domain 76
ZBTB44 zinc finger and BTB domain containing 44
ZNF14 zinc finger protein 14
ZNF165 zinc finger protein 165
ZNF189 zinc finger protein 189
ZNF212 zinc finger protein 212
ZNF239 zinc finger protein 239
ZNF318 zinc finger protein 318
ZNF430 zinc finger protein 430
ZNF562 zinc finger protein 562
ZNF652 zinc finger protein 652
ZNF91 zinc finger protein 91