norcyclobenzaprine-4190 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the norcyclobenzaprine-4190 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD6 abhydrolase domain containing 6
AIM1L absent in melanoma 1-like
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ARHGAP35 Rho GTPase activating protein 35
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AURKC aurora kinase C
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BTG2 BTG family, member 2
C11ORF16 chromosome 11 open reading frame 16
C11ORF63 chromosome 11 open reading frame 63
C15ORF39 chromosome 15 open reading frame 39
C1ORF54 chromosome 1 open reading frame 54
CCKAR cholecystokinin A receptor
CCL22 chemokine (C-C motif) ligand 22
CCNG2 cyclin G2
CD52 CD52 molecule
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEND1 cell cycle exit and neuronal differentiation 1
CLCN7 chloride channel, voltage-sensitive 7
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNOT3 CCR4-NOT transcription complex, subunit 3
CNTNAP2 contactin associated protein-like 2
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK2 death-associated protein kinase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EDN3 endothelin 3
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FAM102A family with sequence similarity 102, member A
FAM205BP transmembrane protein C9orf144B pseudogene
FAM212B family with sequence similarity 212, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FBXO22 F-box protein 22
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF18 fibroblast growth factor 18
FLT1 fms-related tyrosine kinase 1
GAB1 GRB2-associated binding protein 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GHRHR growth hormone releasing hormone receptor
GRB7 growth factor receptor-bound protein 7
HABP4 hyaluronan binding protein 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DOA major histocompatibility complex, class II, DO alpha
HMOX1 heme oxygenase 1
HOXB7 homeobox B7
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IGHD immunoglobulin heavy constant delta
IL2RG interleukin 2 receptor, gamma
INS insulin
INSIG1 insulin induced gene 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LARGE like-glycosyltransferase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEGF9 multiple EGF-like-domains 9
MORC1 MORC family CW-type zinc finger 1
MPPE1 metallophosphoesterase 1
MYOZ1 myozenin 1
NFASC neurofascin
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHA5 protocadherin alpha 5
PDE4DIP phosphodiesterase 4D interacting protein
PF4V1 platelet factor 4 variant 1
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PNRC1 proline-rich nuclear receptor coactivator 1
PRKCA protein kinase C, alpha
RAD52 RAD52 homolog (S. cerevisiae)
RAP2B RAP2B, member of RAS oncogene family
RCE1 Ras converting CAAX endopeptidase 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIC3 RIC3 acetylcholine receptor chaperone
RTN2 reticulon 2
RXRB retinoid X receptor, beta
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2D3C SH2 domain containing 3C
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRPX2 sushi-repeat containing protein, X-linked 2
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYCE1L synaptonemal complex central element protein 1-like
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBC1D30 TBC1 domain family, member 30
TLE4 transducin-like enhancer of split 4
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
UNC13A unc-13 homolog A (C. elegans)
ZBTB20 zinc finger and BTB domain containing 20
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADTRP androgen-dependent TFPI-regulating protein
AEN apoptosis enhancing nuclease
AKR1C4 aldo-keto reductase family 1, member C4
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOLD1 apolipoprotein L domain containing 1
ATAD5 ATPase family, AAA domain containing 5
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BNC1 basonuclin 1
C10ORF2 chromosome 10 open reading frame 2
C22ORF29 chromosome 22 open reading frame 29
C22ORF46 chromosome 22 open reading frame 46
CAMKMT calmodulin-lysine N-methyltransferase
CDKN2AIP CDKN2A interacting protein
CENPO centromere protein O
CLCN5 chloride channel, voltage-sensitive 5
CLTCL1 clathrin, heavy chain-like 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF17 DDB1 and CUL4 associated factor 17
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAH17 dynein, axonemal, heavy chain 17
DNAH7 dynein, axonemal, heavy chain 7
DUSP9 dual specificity phosphatase 9
EBF2 early B-cell factor 2
EGR2 early growth response 2
ERCC2 excision repair cross-complementation group 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GIF gastric intrinsic factor (vitamin B synthesis)
GLDC glycine dehydrogenase (decarboxylating)
GPR1 G protein-coupled receptor 1
GSTCD glutathione S-transferase, C-terminal domain containing
HDAC7 histone deacetylase 7
HIST1H2AJ histone cluster 1, H2aj
HIST1H3F histone cluster 1, H3f
ICOS inducible T-cell co-stimulator
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL24 interleukin 24
IL6 interleukin 6
ISYNA1 inositol-3-phosphate synthase 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA0020 KIAA0020
KRT86 keratin 86, type II
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LMO7 LIM domain 7
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC61 leucine rich repeat containing 61
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEH1 melanoma antigen family H1
MAL mal, T-cell differentiation protein
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MATN3 matrilin 3
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MOCS3 molybdenum cofactor synthesis 3
MRPL41 mitochondrial ribosomal protein L41
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NPM3 nucleophosmin/nucleoplasmin 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PADI1 peptidyl arginine deiminase, type I
PALMD palmdelphin
PEX26 peroxisomal biogenesis factor 26
PLD3 phospholipase D family, member 3
PMCH pro-melanin-concentrating hormone
PPCDC phosphopantothenoylcysteine decarboxylase
PRDM14 PR domain containing 14
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPRE protein tyrosine phosphatase, receptor type, E
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RPP25 ribonuclease P/MRP 25kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
S1PR1 sphingosine-1-phosphate receptor 1
SLC12A8 solute carrier family 12, member 8
SOX21 SRY (sex determining region Y)-box 21
SP140L SP140 nuclear body protein-like
SPIDR scaffolding protein involved in DNA repair
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMPRSS4 transmembrane protease, serine 4
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
USP20 ubiquitin specific peptidase 20
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB48 zinc finger and BTB domain containing 48
ZNF215 zinc finger protein 215
ZNF230 zinc finger protein 230
ZNF415 zinc finger protein 415
ZNF480 zinc finger protein 480
ZNF492 zinc finger protein 492