nonsyndromic deafness Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms. (Human Disease Ontology, DOID_0050563)
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Genes

260 genes co-occuring with the disease nonsyndromic deafness in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GJB2 gap junction protein, beta 2, 26kDa 3.71391
GJB6 gap junction protein, beta 6, 30kDa 2.60632
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.5233
TMC1 transmembrane channel-like 1 2.34788
MYO15A myosin XVA 2.30085
POU3F4 POU class 3 homeobox 4 2.20843
TMPRSS3 transmembrane protease, serine 3 2.20363
OTOF otoferlin 2.18235
TECTA tectorin alpha 2.12865
GJB3 gap junction protein, beta 3, 31kDa 2.04641
MYO7A myosin VIIA 2.00332
CDH23 cadherin-related 23 1.98296
MYH14 myosin, heavy chain 14, non-muscle 1.95488
DFNB59 deafness, autosomal recessive 59 1.94548
TMPRSS4 transmembrane protease, serine 4 1.93562
UCN urocortin 1.91267
TMIE transmembrane inner ear 1.80923
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 1.76773
PCDH15 protocadherin-related 15 1.7446
TPRN taperin 1.72502
DFNA5 deafness, autosomal dominant 5 1.72092
GRXCR1 glutaredoxin, cysteine rich 1 1.70087
POU4F3 POU class 4 homeobox 3 1.67819
CLDN14 claudin 14 1.66735
LHFPL5 lipoma HMGIC fusion partner-like 5 1.66375
USH1C Usher syndrome 1C (autosomal recessive, severe) 1.63366
STRCP1 stereocilin pseudogene 1 1.61575
STRC stereocilin 1.61575
DFNB31 deafness, autosomal recessive 31 1.58582
GIPC3 GIPC PDZ domain containing family, member 3 1.57645
GJC3 gap junction protein, gamma 3, 30.2kDa 1.53877
MYO3A myosin IIIA 1.53657
COCH cochlin 1.53392
TRIOBP TRIO and F-actin binding protein 1.50359
SLC26A5 solute carrier family 26 (anion exchanger), member 5 1.46803
FOXI1 forkhead box I1 1.46451
GPSM2 G-protein signaling modulator 2 1.43639
MARVELD2 MARVEL domain containing 2 1.43288
MYO6 myosin VI 1.43025
OTOG otogelin 1.42498
COL11A2 collagen, type XI, alpha 2 1.41884
OTOA otoancorin 1.41446
ILDR1 immunoglobulin-like domain containing receptor 1 1.39826
ESPN espin 1.36117
TECTB tectorin beta 1.36074
PPP1R18 protein phosphatase 1, regulatory subunit 18 1.35986
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 1.35333
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 1.311
MYO1A myosin IA 1.28697
CRYM crystallin, mu 1.25994
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 1.24689
LOXHD1 lipoxygenase homology domains 1 1.2382
GTPBP3 GTP binding protein 3 (mitochondrial) 1.23603
ELMOD3 ELMO/CED-12 domain containing 3 1.23603
CEMIP cell migration inducing protein, hyaluronan binding 1.22865
WFS1 Wolfram syndrome 1 (wolframin) 1.19748
ZAN zonadhesin (gene/pseudogene) 1.17593
CIB2 calcium and integrin binding family member 2 1.15112
MRPS12 mitochondrial ribosomal protein S12 1.15027
ZNF57 zinc finger protein 57 1.14433
MTO1 mitochondrial tRNA translation optimization 1 1.13543
DCANP1 dendritic cell-associated nuclear protein 1.11687
ESRRB estrogen-related receptor beta 1.1009
GPR139 G protein-coupled receptor 139 1.09755
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.09209
TMEM2 transmembrane protein 2 1.09041
GJB4 gap junction protein, beta 4, 30.3kDa 1.08034
PDZD7 PDZ domain containing 7 1.07866
ZFAND5 zinc finger, AN1-type domain 5 1.05009
TMC3 transmembrane channel-like 3 1.05009
MSRB3 methionine sulfoxide reductase B3 1.02903
RAB8B RAB8B, member RAS oncogene family 1.01427
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.994861
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.975482
GJD4 gap junction protein, delta 4, 40.1kDa 0.96918
ADGRV1 adhesion G protein-coupled receptor V1 0.952438
TMPRSS5 transmembrane protease, serine 5 0.943274
USH1G Usher syndrome 1G (autosomal recessive) 0.93497
TBC1D24 TBC1 domain family, member 24 0.934141
C21ORF2 chromosome 21 open reading frame 2 0.931242
GRHL2 grainyhead-like 2 (Drosophila) 0.921323
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.907731
HMX3 H6 family homeobox 3 0.905675
PTPRQ protein tyrosine phosphatase, receptor type, Q 0.890078
QSOX2 quiescin Q6 sulfhydryl oxidase 2 0.890078
SYT14 synaptotagmin XIV 0.859771
FAM3D family with sequence similarity 3, member D 0.817976
MIR96 microRNA 96 0.813052
LHFPL3 lipoma HMGIC fusion partner-like 3 0.807718
LRRC18 leucine rich repeat containing 18 0.800744
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 0.797872
CCDC50 coiled-coil domain containing 50 0.794181
ZNF664 zinc finger protein 664 0.787213
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.783526
FAM3C family with sequence similarity 3, member C 0.778613
MYO1F myosin IF 0.777386
EMG1 EMG1 N1-specific pseudouridine methyltransferase 0.774932
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.768801
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.767167
CRYGN crystallin, gamma N 0.75412
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.745985
FAM3A family with sequence similarity 3, member A 0.743547
SYT3 synaptotagmin III 0.732596
EYA4 EYA transcriptional coactivator and phosphatase 4 0.727738
MYH9 myosin, heavy chain 9, non-muscle 0.727333
DIAPH1 diaphanous-related formin 1 0.717232
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.683493
TFB1M transcription factor B1, mitochondrial 0.682693
ARHGAP17 Rho GTPase activating protein 17 0.682693
KPTN kaptin (actin binding protein) 0.676706
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.675909
PFKL phosphofructokinase, liver 0.664769
EMILIN2 elastin microfibril interfacer 2 0.663578
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.65565
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.655254
SLC26A8 solute carrier family 26 (anion exchanger), member 8 0.654067
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 0.647743
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.638282
GIPC2 GIPC PDZ domain containing family, member 2 0.632777
GJA1 gap junction protein, alpha 1, 43kDa 0.625319
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.610838
MYO9A myosin IXA 0.604201
GJB5 gap junction protein, beta 5, 31.1kDa 0.60303
MRPL12 mitochondrial ribosomal protein L12 0.59991
SIX1 SIX homeobox 1 0.598351
UBE3B ubiquitin protein ligase E3B 0.592116
SLC26A7 solute carrier family 26 (anion exchanger), member 7 0.586665
INSC inscuteable homolog (Drosophila) 0.585108
ANO10 anoctamin 10 0.582773
TPCN2 two pore segment channel 2 0.576161
CATSPER2 cation channel, sperm associated 2 0.574994
ADARB1 adenosine deaminase, RNA-specific, B1 0.568386
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.559839
COL4A5 collagen, type IV, alpha 5 0.558285
BTF3 basic transcription factor 3 0.550522
TJP2 tight junction protein 2 0.547419
ATE1 arginyltransferase 1 0.545868
UBASH3A ubiquitin associated and SH3 domain containing A 0.531541
CRYBA2 crystallin, beta A2 0.526904
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.519575
RGS19 regulator of G-protein signaling 19 0.51842
RAB40AL RAB40A, member RAS oncogene family-like 0.517265
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.511496
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.508808
ZNRF4 zinc and ring finger 4 0.507273
GSDMA gasdermin A 0.503824
MIR183 microRNA 183 0.501527
DIAPH3 diaphanous-related formin 3 0.500379
RDX radixin 0.499997
CRYL1 crystallin, lambda 1 0.493885
DOCK5 dedicator of cytokinesis 5 0.49274
DOCK2 dedicator of cytokinesis 2 0.491215
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.489311
ARL2 ADP-ribosylation factor-like 2 0.476393
OPRD1 opioid receptor, delta 1 0.475255
KALRN kalirin, RhoGEF kinase 0.470711
PHKB phosphorylase kinase, beta 0.469954
CPSF3L cleavage and polyadenylation specific factor 3-like 0.469197
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 0.464283
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.463905
CRYBB3 crystallin, beta B3 0.446935
PANX2 pannexin 2 0.434148
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.428891
FAM3B family with sequence similarity 3, member B 0.42814
DOCK4 dedicator of cytokinesis 4 0.422515
DEFA3 defensin, alpha 3, neutrophil-specific 0.419892
CIB1 calcium and integrin binding 1 (calmyrin) 0.411283
CLRN1 clarin 1 0.405678
DNAH12 dynein, axonemal, heavy chain 12 0.401572
DNAH14 dynein, axonemal, heavy chain 14 0.401572
GBA2 glucosidase, beta (bile acid) 2 0.398216
HPN hepsin 0.393374
KIAA1109 KIAA1109 0.376661
FZD10 frizzled class receptor 10 0.374438
CISD2 CDGSH iron sulfur domain 2 0.372958
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 0.372217
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 0.361133
PDE9A phosphodiesterase 9A 0.359289
GJA3 gap junction protein, alpha 3, 46kDa 0.359289
CRYBA4 crystallin, beta A4 0.355235
NEUROD1 neuronal differentiation 1 0.350452
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.350084
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.348614
CRYBA1 crystallin, beta A1 0.346777
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.342372
NID1 nidogen 1 0.331025
PRMT2 protein arginine methyltransferase 2 0.327375
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.324094
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.322273
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.320817
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.318272
MYOF myoferlin 0.316456
DIO3 deiodinase, iodothyronine, type III 0.313552
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.312464
TFF1 trefoil factor 1 0.309928
VANGL2 VANGL planar cell polarity protein 2 0.30342
GIPC1 GIPC PDZ domain containing family, member 1 0.28616
RAD17 RAD17 homolog (S. pombe) 0.281868
ACTG1 actin gamma 1 0.269043
LIG3 ligase III, DNA, ATP-dependent 0.264431
DNAH9 dynein, axonemal, heavy chain 9 0.257711
SCN3A sodium channel, voltage gated, type III alpha subunit 0.256299
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.247501
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.24715
C1QBP complement component 1, q subcomponent binding protein 0.23945
COL4A6 collagen, type IV, alpha 6 0.231102
GJC1 gap junction protein, gamma 1, 45kDa 0.222479
CRYBB1 crystallin, beta B1 0.221108
FNDC3A fibronectin type III domain containing 3A 0.219398
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.212271
GH2 growth hormone 2 0.210253
RHOA ras homolog family member A 0.201962
DNAH5 dynein, axonemal, heavy chain 5 0.200331
CORIN corin, serine peptidase 0.19582
DLX5 distal-less homeobox 5 0.185313
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.182957
NEUROG1 neurogenin 1 0.179239
DIO2 deiodinase, iodothyronine, type II 0.177301
CLCN7 chloride channel, voltage-sensitive 7 0.177029
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.174354
PCNT pericentrin 0.16933
EYA1 EYA transcriptional coactivator and phosphatase 1 0.165217
FGF9 fibroblast growth factor 9 0.15948
CHM choroideremia (Rab escort protein 1) 0.143826
GK glycerol kinase 0.143467
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.143247
SARS seryl-tRNA synthetase 0.143175
AQP3 aquaporin 3 (Gill blood group) 0.14281
FBXO17 F-box protein 17 0.142762
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.142533
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.142453
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.141896
PGRMC1 progesterone receptor membrane component 1 0.141779
FGF1 fibroblast growth factor 1 (acidic) 0.14124
COL11A1 collagen, type XI, alpha 1 0.140578
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.140169
BTK Bruton agammaglobulinemia tyrosine kinase 0.140091
TFF2 trefoil factor 2 0.139981
OCA2 oculocutaneous albinism II 0.139756
SOX2 SRY (sex determining region Y)-box 2 0.139449
PAX2 paired box 2 0.139217
ALAD aminolevulinate dehydratase 0.139089
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.138539
TFAM transcription factor A, mitochondrial 0.137542
TFF3 trefoil factor 3 (intestinal) 0.13742
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.13742
FMR1 fragile X mental retardation 1 0.136815
PTPRS protein tyrosine phosphatase, receptor type, S 0.136693
FGF19 fibroblast growth factor 19 0.136467
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.13634
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.135805
MMP11 matrix metallopeptidase 11 0.135466
C3 complement component 3 0.135007
PARK2 parkin RBR E3 ubiquitin protein ligase 0.13431
DYSF dysferlin 0.132489
CCL4 chemokine (C-C motif) ligand 4 0.1288
MPZ myelin protein zero 0.128772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.128136
MAP4 microtubule-associated protein 4 0.127866
NDP Norrie disease (pseudoglioma) 0.127775